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ENZO LIFE SCIENCES
Numéro de catalogue:
(ENZOBMLEI3480050)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Selectively inhibits monoacylglycerol (MAG) lipase (IC50=28µM) via a noncompetitive mechanism. Does not inhibit FAAH, DAG lipase or COX-2. URB-602 selectively raises levels of 2-arachidonoylglycerol with no change in anandamide concentrationsin cells and tissues. In the same way anandamide levels were markely elevated by the FAAH inhibitor URB597 at 1µM.
UOM:
1 * 50 mg
New Product
Numéro de catalogue:
(ENZOBMLEI3600005)
Fournisseur:
ENZO LIFE SCIENCES
Description:
PD-98059 is a potent and selective inhibitor of MAP kinase kinase (MEK). It selectively blocks the activation of MEK thereby inhibiting the phosphorylation and the activation of MAP kinase. PD-98059 is cell permeable. In PC12 pheochromocytoma cells, it completely blocked the increase in MAP kinase activity produced by NGF, IC50=2µM. Enhances self-renewal of embryonic stem cells PD-98059 is an invaluable tool to help elucidate the role of the MAPK cascade in a variety of biological systems. Inhibits cell growth and proliferation in acute myelogenous leukemia cell lines by causing cell arrest.
UOM:
1 * 5 mg
New Product
Numéro de catalogue:
(ENZOBMLEI3410001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
A useful tool for affinity purification of HSP-90 and HSP-90 dependent client proteins.
UOM:
1 * 1 mg
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in <i>E. coli</i>.
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in <i>E. coli</i>.
Fournisseur:
ENZO LIFE SCIENCES
Description:
Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.
Fournisseur:
ENZO LIFE SCIENCES
Description:
Member of the tyrphostin family of tyrosine kinase inhibitors. Selective inhibitor of the PDGF receptor kinase (IC50=20µM) vs. the EGF receptor kinase (IC50=820µM). Inhibits PDGF-induced mitogenesis in human bone marrow fibroblasts.
Fournisseur:
ENZO LIFE SCIENCES
Description:
Cyclooxygenase inhibitor. Selectively inhibits PGH synthase-2 (IC50=1 µM) with no inhibition of PGH synthase-1 at concentrations up to 100 µM. Protects neuronal cultures from LPS-induced neurotoxicity.
Fournisseur:
ENZO LIFE SCIENCES
Description:
Inhibits PKCα (IC50=43 µM) and PKCγ (IC50=50 µM) without inhibiting the δ, βI and βII isotypes.
Fournisseur:
ENZO LIFE SCIENCES
Description:
AG-490 is a potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently inhibited DNA synthesis, blocked cell growth and induced apoptosis. At 5 µM, AG-490 almost completely blocked the growth of all pre-B ALL cells but had no significant effect on the growth of mitogen-stimulated normal B or T cells, B-cell lymphoma or T-cell leukemia cells. AG-490 does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. It blocks interleukin-7-induced JAK kinase activity in T-cells (JAK-1, JAK-3) and the consequent phosphorylation of PI-3 kinase. AG-490 is cell permeable and is a valuable tool for studying the cellular role of JAK kinases in signal transduction.
Fournisseur:
ENZO LIFE SCIENCES
Description:
Src kinase inhibitor
Fournisseur:
ENZO LIFE SCIENCES
Description:
Inhibits Rho kinase (ROCK; Ki=0.33μM). Selective protein kinase A and G inhibitor (both Ki’s = 1.6μM). Inhibits agonist-induced activation of NADPH oxidase in human neutrophils (IC50=15μM). Inhibitor of myosin light chain kinase and Ca2+/calmodulin-dependent protein kinase II. Inhibits translocation of PKCβI, PKCβII and PKCζ. Cell permeable Ca2+ antagonist with antivasospastic properties.
Numéro de catalogue:
(ENZOBMLSA3610100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Host: Rabbit
UOM:
1 * 100 µl
New Product
Numéro de catalogue:
(ENZOBMLSA2540100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Host: Rabbit
UOM:
1 * 100 µl
New Product
Fournisseur:
ENZO LIFE SCIENCES
Description:
Host: Rabbit
Numéro de catalogue:
(ENZOBMLSA2870100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Recommended Applications: ELISA, Flow Cytometry, ICC, IF, IHC, IHC (FS), IHC (PS), IP, WB
Species reactivity: Human, Mouse, Rat, Sheep, Rabbit, Porcine, Monkey, Ferret, Bovine
UOM:
1 * 100 µl
New Product
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