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ProSci Inc.
Numéro de catalogue:
(PRSI33-239)
Fournisseur:
ProSci Inc.
Description:
This antibody recognises HMW Keratin 1, 5, 10 and 14. In normal epithelia, it stains stratified epithelia, myoepithelial cells and basal cells in the prostate gland and bronchi. The HMW Cytokeratin antibody shows no reactivity with hepatocytes, pancreatic acinar cells, proximal renal tubules, or endometrial glands; there is no reactivity with cells derived from simple epithelia. Mesenchymal tumors, lymphomas, melanomas, neural tumors, and neuroendocrine tumors are negative with this mAb. It stains myoepithelial cells and has been shown to be useful in distinguishing prostate adenocarcinoma from benign prostate. It has also been useful in separating benign from malignant intraductal breast proliferations.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI46-261)
Fournisseur:
ProSci Inc.
Description:
Anti-RAD51L3 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXW-7528)
Fournisseur:
ProSci Inc.
Description:
Regulator of G-protein signalling 18. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi and Gq class G-beta proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSIXW-7407)
Fournisseur:
ProSci Inc.
Description:
Nuclear factor κ-B DNA binding subunit; Nuclear factor of κ light chain gene enhancer in B-cells 1 (p105). NFκB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFκB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-κ-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-κ-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI42-159)
Fournisseur:
ProSci Inc.
Description:
Anti-CXCL2 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXW-7700)
Fournisseur:
ProSci Inc.
Description:
FUNCTION: Stores iron in a soluble, nontoxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.
CATALYTIC ACTIVITY: 4 Fe2++ 4 H++ O2 = 4 Fe3++ 2 H2O. SUBUNIT: Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI42-572)
Fournisseur:
ProSci Inc.
Description:
Anti-FANCM Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI80-044)
Fournisseur:
ProSci Inc.
Description:
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXW-8122)
Fournisseur:
ProSci Inc.
Description:
Anti-TCOF1 Chicken Polyclonal Antibody
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSIXW-8124)
Fournisseur:
ProSci Inc.
Description:
FUNCTION: Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is the catalytic subunit.
CATALYTIC ACTIVITY: ATP + H2O + H+(In) = ADP + phosphate + H+(Out). SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: beta(3), beta(3), gamma(1), δ(1), epsilon. CF(0) has three main subunits: a, b and c.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI80-029)
Fournisseur:
ProSci Inc.
Description:
Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, leading to promote their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2: it thereby regulates inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, B-cell differentiation in the germinal center in response to DNA damage. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton. Required for cortical neurons polarization by mediating phosphorylation and activation of BRSK1 and BRSK2, leading to axon initiation and specification. Involved in DNA damage response: interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation. Able to phosphorylate p53/TP53; the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1 Also acts as a mediator p53/TP53-dependent apoptosis via interaction with p53/TP53: translocates to mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-991)
Fournisseur:
ProSci Inc.
Description:
PDGF Receptor β encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-983)
Fournisseur:
ProSci Inc.
Description:
Plays a role in leptin signaling and control of body weight
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-981)
Fournisseur:
ProSci Inc.
Description:
Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also phosphorylates NCOA3.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI80-014)
Fournisseur:
ProSci Inc.
Description:
Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress. Required for the targeting, or stabilization, of BLM to non-centromeric abnormal structures induced by replicative stress. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI46-790)
Fournisseur:
ProSci Inc.
Description:
Anti-ABCA6 Goat Polyclonal Antibody
UOM:
1 * 1 EA
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est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
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