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ProSci Inc.
Numéro de catalogue:
(PRSIPM-4527)
Fournisseur:
ProSci Inc.
Description:
PUMA Monoclonal Antibody: Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMAα and PUMAβ. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIPM-4845)
Fournisseur:
ProSci Inc.
Description:
MD-2 Monoclonal Antibody: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIPM-4847)
Fournisseur:
ProSci Inc.
Description:
MD-2 Monoclonal Antibody: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI71-090)
Fournisseur:
ProSci Inc.
Description:
Anti-SLC11A2 Rabbit Polyclonal Antibody
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI71-087)
Fournisseur:
ProSci Inc.
Description:
Anti-CADM2 Rabbit Polyclonal Antibody
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI71-106)
Fournisseur:
ProSci Inc.
Description:
Anti-ENPP3 Rabbit Polyclonal Antibody
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSIXW-8138)
Fournisseur:
ProSci Inc.
Description:
FUNCTION: Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.
SIMILARITY: Belongs to the SLC12A transporter family. SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in many tissues.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSIPM-4821)
Fournisseur:
ProSci Inc.
Description:
Bim Monoclonal Antibody: Members in the Bcl-2 family are critical regulators of apoptosis by either inhibiting or promoting cell death. Bcl-2 homology 3 (BH3) domain is a potent death domain. BH3 domain containing pro-apoptotic proteins, including Bad, Bax, Bid, Bik, and Hrk, form a growing subclass of the Bcl-2 family. Bim is another BH3 domain containing protein which can induce apoptosis. Bim interacts with diverse members in the pro-survival Bcl-2 sub-family including Bcl-2, Bcl-xL and Bcl-w. The messenger RNA of Bim is ubiquitously expressed in multiple tissues and cell lines.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI2255P)
Fournisseur:
ProSci Inc.
Description:
SnoN peptide is used for blocking activity of SnoN antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2271P)
Fournisseur:
ProSci Inc.
Description:
FLASH peptide is used for blocking the activity of FLASH antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-601)
Fournisseur:
ProSci Inc.
Description:
The function remains unknown.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-569)
Fournisseur:
ProSci Inc.
Description:
Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth.Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-570)
Fournisseur:
ProSci Inc.
Description:
Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth.Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-589)
Fournisseur:
ProSci Inc.
Description:
PHF13 contains 1 PHD-type zinc finger. The function of the PHF13 protein remains unknown.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-602)
Fournisseur:
ProSci Inc.
Description:
CDC45L was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7709)
Fournisseur:
ProSci Inc.
Description:
LAMTOR1 is a 161 amino acid membrane protein belonging to the LAMTOR family. It has been identified to interact with and recruit the four Rag GTPases (Rag A-D) to the surface of lysosomes. The mTORC1 kinase complex is a critical component in the regulation of cell growth. As part of the ragulator complex, LAMTOR1 recruits the Rag GTPases and the mTORC1 complex to lysosomes, a key step in activation of the TOR signaling cascade by amino acids. LAMTOR1 may be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes / lysosomes.
UOM:
1 * 1 EA
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