STEMCELL Technologies
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD90 (Thy-1), PE-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Leukemia inhibitory factor (LIF) is an interleukin 6 class cytokine that regulates a broad variety of developmental functions. After LIF binds to the LIF receptor (LIFR), LIFR associates with gp130 and activates JAK/STAT and MAPK signaling (Auernhammer and Melmed; Suman <i>et al.</i>). LIFR activation of STAT3 is essential for maintaining the mouse embryonic stem cell phenotype (Niwa <i>et al.</i>). Produced by the endometrium, LIF plays an important autocrine and paracrine role in implantation by regulating proliferation, invasion, and differentiation of trophoblasts following blastocyst attachment (Auernhammer and Melmed; Suman <i>et al.</i>). Human LIF can be used for the maintenance of mouse embryonic stem cells; however, mouse LIF cannot bind to the human receptor, thus rendering mouse LIF inactive (Dahéron <i>et al.</i>). LIF is produced by CD4+ and activated regulatory T cells, and promotes Foxp3 expression, while repressing Th17 lineage-specific genes (Metcalfe). LIF is also secreted by mesenchymal stromal cells, where it supports hematopoiesis and immune modulation (Nasef <i>et al.</i>).
Fournisseur:
STEMCELL Technologies
Description:
Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor and a member of the tumor growth factor (TGF)-beta superfamily. The GDNF family of growth factors also includes neurturin, persephin, and artemin, which have seven conserved cysteine residues called cysteine-knots (Treanor <i>et al.</i>). GDNF family ligands signal through binding to specific GDNF-family receptor-α (GFRα) co-receptors and activate the RET receptor tyrosine kinase (Durbec <i>et al.</i>). Four different forms of GFRα co-receptors have been characterized (GFRα 1-4); GDNF binds specifically to GFRα1 prior to forming a complex with RET (Airaksinen and Saarma). GDNF is known to promote survival and morphological differentiation of midbrain dopaminergic neurons in both <i>in vivo</i> and in vitro studies and increases their high-affinity dopamine uptake (Granholm <i>et al.</i>; Lin <i>et al.</i>). GDNF has also been shown to have restorative effects on dying dopaminergic neurons in response to degenerative toxins (Aoi <i>et al.</i>). GDNF, together with Human Recombinant BDNF (brain-derived neurotrophic factor), BrainPhys™ Neuronal Medium, and other supplements, can be used to differentiate human pluripotent stem cell (hPSC)-derived neural progenitor cells into neurons (Bardy <i>et al.</i>).
Fournisseur:
STEMCELL Technologies
Description:
Platelet-derived growth factor (PDGF) is a dimeric glycoprotein consisting of two disulfide bridge stabilized polypeptide chains, A and B, which are assembled as heterodimers (PDGF-AB) or homodimers (PDGF-AA and PDGF-BB) (Fretto <i>et al.</i>; Westermark and Heldin). PDGF signals through the receptor tyrosine kinases PDGFRalpha and PDGFRbeta. It has been shown that PDGF-induced migration involves signaling pathways involving MEK/ERK, EGFR, Src and PI3K/AKT (Kim <i>et al.</i>). PDGF is a potent mitogen for cells of mesenchymal origin- like fibroblasts, glial cells, and vascular smooth muscle cells. PDGF has been implicated in pathogenesis of atherosclerosis, glomerulonephritis, cancer, and in the contraction of vascular smooth muscle cells of rat aortic tissues (Fretto <i>et al.</i>; Sachinidis <i>et al.</i>). PDGF-BB is secreted by osteoblasts to induce mesenchymal stem cell migration and angiogenesis. It has also been shown that PDGF-BB is secreted by preosteoclasts during bone modeling and remodeling to induce angiogenesis and thus proper osteogenesis (Xie <i>et al.</i>).
Fournisseur:
STEMCELL Technologies
Description:
RANTES (regulated upon activation, normal T cell expressed and secreted), also known as CCL5, is a member of the CC family of chemokines and is able to recruit leukocytes to sites of inflammation (Schall <i>et al.</i>). RANTES is secreted by T lymphocytes, macrophages, platelets, synovial fibroblasts, tubular epithelium, and certain types of tumor cells (Aldinucci and Colombatti; Soria and Ben-Baruch). This chemokine exerts its effect by interacting with the chemokine receptors CCR1, CCR3, CCR4, and CCR5. RANTES plays an active role in recruiting a variety of leukocytes into inflammatory sites, including T cells, macrophages, eosinophils, and basophils. In collaboration with certain cytokines that are released by T cells such as IL-2 and IFN-γ, RANTES also induces the activation and proliferation of NK cells to generate CC chemokine-activated killer cells, which are highly cytolytic (Lv <i>et al.</i>; Maghazachi <i>et al.</i>). It has been shown that RANTES produced by CD8+ T cells inhibits HIV infection of primary human peripheral blood mononuclear cells (Appay and Rowland-Jones; Cocchi <i>et al.</i>).
Fournisseur:
STEMCELL Technologies
Description:
Noggin binds to and antagonizes bone morphogenetic protein (BMP) ligands of the transforming growth factor beta (TGF-β) family. Noggin supports maintenance of undifferentiated human embryonic stem cells in vitro, and can be used to prevent spontaneous differentiation in the short term (Chaturvedi <i>et al.</i>). Noggin is essential for development of structures derived from ectoderm embryonic somite, skeletal patterning, and neurogenesis in vivo. It also influences chondrogenesis, osteogenesis, and joint formation (Krause <i>et al.</i>), and promotes dopaminergic differentiation of embryonic stem cells and subsequent survival of dopamine neurons (Chiba <i>et al.</i>).
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG2b antibody against human, rhesus, cynomolgus CD4, FITC-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Hamster (Armenian) monoclonal IgG1 antibody against mouse CD3e, FITC-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgM antibody against human, rhesus, rabbit TRA160 (podocalyxin), Alexa Fluor® 488-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Immunomagnetic isolation of untouched human CD4+CD127lowCD49d- T cells
Fournisseur:
STEMCELL Technologies
Description:
Rat monoclonal IgG2b antibody against mouse CD24, Alexa Fluor® 488-conjugated.
Numéro de catalogue:
(STMC04962)
Fournisseur:
STEMCELL Technologies
Description:
Staining kit for human CFU-Mk assays - 1 kit.
UOM:
1 * 1 KIT
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Numéro de catalogue:
(STMC60159PE)
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG1 antibody against human CD298, PE-conjugated.
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC60147FI)
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG1 antibody against human epithelial cells, FITC-conjugated.
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
STEMCELL Technologies
Description:
Rat monoclonal IgG2b antibody against mouse CD45, unconjugated.
Fournisseur:
STEMCELL Technologies
Description:
Hamster (Armenian) monoclonal IgG2 antibody against mouse T cell receptor gamma/delta, FITC-conjugated.
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