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STEMCELL Technologies
Fournisseur:
STEMCELL Technologies
Description:
Platelet-derived growth factor (PDGF) is a dimeric glycoprotein consisting of two disulfide bridge-stabilized polypeptide chains, A and B, which are assembled as heterodimers (PDGF-AB) or homodimers (PDGF-AA and PDGF-BB) (Fretto <i>et al.</i>; Westermark and Heldin). PDGF signals through the receptor tyrosine kinases PDGFRalpha and PDGFRbeta. It has been shown that PDGF-induced migration involves signaling pathways involving MEK/ERK, EGFR, Src, and PI3K/AKT (Kim <i>et al.</i>). PDGF is a potent mitogen for cells of mesenchymal origin- like fibroblasts, glial cells, and vascular smooth muscle cells. PDGF has been implicated in pathogenesis of atherosclerosis, glomerulonephritis, cancer, and in the contraction of vascular smooth muscle cells of rat aortic tissues (Fretto <i>et al.</i>; Sachinidis <i>et al.</i>). It has been shown that PDGF-AB together with 5-Azacytidine (Catalog #72012), induces the conversion of mature bone and fat cells into tissue-regenerative multipotent stem cells (Chandrakanthan <i>et al.</i>).
Numéro de catalogue:
(STMC100-0932)
Fournisseur:
STEMCELL Technologies
Description:
Leptin is a protein produced from the ob gene or lep gene, and acts as both a hormone involved in metabolic function as well as a proinflammatory cytokine by inducing Th1 immune responses (Dunn <i>et al.</i>; La Cava; Newman and Gonzalez-Perez). Leptin is a member of the gp130 family of cytokines and is known to be correlated with obesity (Dixit <i>et al.</i>; Dunn <i>et al.</i>). Leptin can both promote osteogenesis via osteoblast receptors and inhibit it through its actions on the hypothalamus (Figenschau <i>et al.</i>). It is a small, non-glycosylated protein with a highly conserved sequence between species. Leptin binds to the leptin receptor OB-R, which exists in six isoforms in humans and can activate various Janus kinase (JAK) and downstream pathways (Dunn <i>et al.</i>; Münzberg and Morrison; Newman and Gonzalez-Perez). For example, the binding of leptin to LepRb receptor activates JAK2, which leads to the phosphorylation of both JAK2 and the LepRb receptor, with three separate residues on the receptor triggering signaling pathways for SHP-2, STAT5, and STAT3 (Dunn <i>et al.</i>; Münzberg and Morrison). In addition to its effects on mature immune cells, other studies have suggested impacts on other cell types, with activities such as inducing cell proliferation and morphological differentiation in hematopoietic cell lines, chondrocytes, and hepatic cells (Figenschau <i>et al.</i>; Gainsford <i>et al.</i>; Santos-Alvarez <i>et al.</i>; Wang <i>et al.</i>).
UOM:
1 * 2 mg
 Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC100-0937)
Fournisseur:
STEMCELL Technologies
Description:
gAdiponectin, also known as an adipocyte component-related protein of 30 kDa, is a member of defense collagens, and its structure is similar to C1q-a member of the complement-related family of proteins (Chandran <i>et al.</i>). gAdiponectin is expressed by differentiated adipocytes and it is composed of three defined domains: N-terminus-containing hypervariable region, collagenous stalk containing 22 GXY repeats, followed by a C-terminus globular domain (Wang <i>et al.</i>). gAdiponectin has also been identified as a hematopoietic stem cell growth factor (DiMascio <i>et al.</i>), and is known to regulate bone marrow mesenchymal stem cell niche (Yu <i>et al.</i>). The globular domain of adiponectin (gAcrp30) has been shown to significantly reduce plasma-free fatty acids and glucose levels in mice (Wong <i>et al.</i>), and to regulate glucose and fatty acid uptake and oxidation in cardiomyocytes (Palanivel <i>et al.</i>). This product is animal component-free.
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC100-0837)
Fournisseur:
STEMCELL Technologies
Description:
Kit containing C6 NBD ceramide for selectively staining the Golgi apparatus in live or aldehyde-fixed cells - 100 tests.
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC100-0872)
Fournisseur:
STEMCELL Technologies
Description:
Differentiation and maturation kits for generation of motor neurons from human pluripotent stem cells.
UOM:
1 * 1 Kit
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Numéro de catalogue:
(STMC100-0383)
Fournisseur:
STEMCELL Technologies
Description:
Culture medium kit for differentiation of human liver organoids.
UOM:
1 * 1 Kit
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC100-0649)
Fournisseur:
STEMCELL Technologies
Description:
The SARS-CoV-2 (ORF3a) Peptide pool is a lyophilised mixture of 66 peptides from open reading frame 3a (ORF3a) protein of SARS-CoV-2. ORF3a is found in both SARS-CoV and SARS-CoV-2 and the two proteins share high sequence similarity. SARS-CoV ORF3a has been shown to cause apoptosis of infected cells and form potassium-sensitive ion channels, modulating the release of viruses. Additionally, it induces ligand-independent downregulation of Type 1 interferon receptor. The sequence similarity between the two proteins suggests it may play a similar role in SARS-CoV-2. The pool consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 275 on SARS-CoV-2 ORF3a.
UOM:
1 * 1 Kit
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC100-0756)
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG1 antibody against human angiotensin-converting enzyme 2 (ACE2).
UOM:
1 * 1 EA
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
STEMCELL Technologies
Description:
SARS-CoV-2 Recombinant Nucleocapsid Protein, aa1-419 is expressed in HEK293 cells and is one of four structural proteins encoded by the SARS-CoV-2 genome. The Nucleocapsid Protein is transcribed from the viral “N” gene and is the protein that interacts with RNA to form the nucleocapsid. The protein forms a homo-oligomer, and both the monomer and the oligomer can interact with RNA. This protein also interacts with the membrane protein (protein M) after infection of the host cell during packaging of the positive-strand viral genome RNA into the ribonucleocapsid during virion assembly.
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal IgG2b, antibody against human, chimpanzee, CD45RA, Biotin-conjugated.
Fournisseur:
STEMCELL Technologies
Description:
Column-free immunomagnetic positive selection of human CD14+ cells for HLA analysis.
Fournisseur:
STEMCELL Technologies
Description:
Immunomagnetic positive selection of any cells labeled with FITC-conjugated antibodies.
Fournisseur:
STEMCELL Technologies
Description:
Immunomagnetic positive selection of human cells labeled with APC-conjugated antibodies.
Fournisseur:
STEMCELL Technologies
Description:
Immunomagnetic positive selection of any human cells labeled with biotinylated antibodies.
Numéro de catalogue:
(STMC05980)
Fournisseur:
STEMCELL Technologies
Description:
Serum-free supplement and attachment substrate for the derivation and expansion of human skeletal muscle progenitor cells (myoblasts).
UOM:
1 * 1 Kit
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC100-0019)
Fournisseur:
STEMCELL Technologies
Description:
Differentiation kit for the generation of microglia precursors from human ES and iPS cell-derived hematopoietic progenitor cells.
UOM:
1 * 1 Kit
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
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