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STEMCELL Technologies
Numéro de catalogue:
(STMC100-1611)
Fournisseur:
STEMCELL Technologies
Description:
Hamster (Armenian) monoclonal antibody against mouse T cell receptor beta, APC-conjugated.
UOM:
1 * 1 EA
New Product
 Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC100-1353)
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal antibody against human, monkey CD137 (ILA).
UOM:
1 * 1 EA
New Product
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC100-1348)
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal antibody against human CD69 (AIM).
UOM:
1 * 100 PE
New Product
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC100-1452)
Fournisseur:
STEMCELL Technologies
Description:
Rat monoclonal antibody against human IL-4, PE-conjugated.
UOM:
1 * 1 EA
New Product
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC100-1607)
Fournisseur:
STEMCELL Technologies
Description:
Rat monoclonal antibody against mouse CD3, APC-conjugated.
UOM:
1 * 1 EA
New Product
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC100-1355)
Fournisseur:
STEMCELL Technologies
Description:
Mouse monoclonal antibody against human, monkey CD137 (ILA).
UOM:
1 * 1 EA
New Product
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC100-1079)
Fournisseur:
STEMCELL Technologies
Description:
Extraction immunomagnétique d'acides nucléiques totaux (ADN et ARN).
UOM:
1 * 1 EA
New Product
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Fournisseur:
STEMCELL Technologies
Description:
For detection and measurement of human immunoglobulin E.
Fournisseur:
STEMCELL Technologies
Description:
For detection and measurement of mouse interleukin 5.
Fournisseur:
STEMCELL Technologies
Description:
For detection and measurement of human interleukin 10.
Fournisseur:
STEMCELL Technologies
Description:
Fibroblast growth factor acidic (FGF-acidic), also known as FGF-1, is a potent activator of DNA synthesis, cell proliferation, and chemotaxis and is known to play numerous roles in development, regeneration, and angiogenesis (Galzie <i>et al.</i>; Jaye <i>et al.</i>; Presta <i>et al.</i>). FGF-acidic is produced by multiple cell types and is capable of activating all cells of mesodermal origin and many cells of neuroectodermal, ectodermal, and endodermal origin. It is found in large quantities in the brain, but is also expressed in hepatocytes, vascular smooth muscle cells, neurons of the central nervous system, skeletal muscle cells, fibroblasts, keratinocytes, endothelial cells, intestinal columnar epithelial cells, and pituitary basophils and acidophils. FGF-acidic is secreted as a disulfide-linked homodimer and is stored in complex with heparan sulfate, a requirement for its interaction with FGF receptors (Guerrini <i>et al.</i>; Mohammadi <i>et al.</i>). Internalized FGF-acidic signals via protein kinase C and promotes cell survival by inhibiting p53 and proapoptotic signaling (Bouleau <i>et al.</i>). This product is animal component-free.
Fournisseur:
STEMCELL Technologies
Description:
Interleukin 21 (IL-21) is a pleiotropic cytokine that is composed of four α-helical bundles and primarily produced by natural killer T (NKT) cells, T follicular helper (Tfh) cells, and Th17 cells (Spolski and Leonard 2008). IL-21 signals via heterodimers of the IL-21 receptor (IL-21R) and the IL2RG-encoded common cytokine receptor γ-chain (Parrish-Novak <i>et al.</i>; Ozaki K <i>et al.</i> 2000), and utilizes the JAK/STAT, MAPK, and PI3K pathways (Spolski and Leonard 2014). IL-21 has been shown to have a critical role in regulating immunoglobulin production and differentiation of the pro-inflammatory Th17 population of cells (Ozaki <i>et al.</i> 2002; Nurieva <i>et al.</i>). Additionally, IL-21 specifically sustains CD8+ T cell effector activity and provides a mechanism of CD4+ T cell help during chronic viral infection (Elsaesser <i>et al.</i>). IL-21 signaling was also found critical for the development of type 1 diabetes in NOD mice (Sutherland <i>et al.</i>) and control of T cell autoimmunity by regulatory B cells (Yoshizaki <i>et al.</i>). This product is animal component-free.
Fournisseur:
STEMCELL Technologies
Description:
Interleukin 1 beta (IL-1β) is synthesised as an inactive precursor protein or pro-IL-1β. This precursor is cleaved intracellularly by Caspase 1 (IL-1β convertase) to form the active form of the protein that is later secreted (Allan <i>et al.</i>). IL-1β binds to IL-1 receptor and activates intracellular signaling via the MAPK or NF-kB pathway. IL-1β is released by monocytes, tissue macrophages, and dendritic cells in response to infection or injury and induces expression of acute-phase proteins. It also promotes the infiltration of inflammatory and immunocompetent cells from the circulation into the extravascular space and affected tissues, by stimulating the expression of adhesion molecules on endothelial cells. IL-1β also affects other immune cells; for example, it co-stimulates T cell functions together with antigen or mitogen. It also stimulates Th17 differentiation and B cell proliferation in an IL-6-dependent manner. This product is animal component-free.
Fournisseur:
STEMCELL Technologies
Description:
Transforming growth factor (TGF) beta 3 is a member of the TGF-β superfamily and regulates diverse cellular phenotypes. TGF-beta 3 binds to serine-threonine kinase type I and II receptors and activates signal transduction through SMAD2/3 proteins, thus regulating a variety of functions, including cell proliferation, differentiation, wound healing, apoptosis, and metabolism (Massagué; McDowell <i>et al.</i>). TGF-beta 3 enhances glycosaminoglycan production by mesenchymal stromal cells, stimulates scar-free healing, and improves glucose tolerance and phenotypic changes in adipocyte morphology (Hall <i>et al.</i>; Holton <i>et al.</i>). TGF-beta 3 induces proliferation of posterofrontal suture-derived mesenchymal stromal cells, and stimulates expression of fibroblast growth factors 2 and 18 (James <i>et al.</i>).
Numéro de catalogue:
(STMC100-1422)
Fournisseur:
STEMCELL Technologies
Description:
Stimulating T cells with SARS-CoV-2 (Spike Protein) Omicron XBB.1.5.X Mutation peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. This pool is provided as two lyophilised mixtures (subpools) from the spike glycoprotein of SARS-CoV-2 Omicron XBB.1.5.X subvariant. The subpools contain 158 and 157 peptides, respectively, for a total of 315 peptides, and consist of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 1269 on the spike protein. Through interactions with the angiotensin-converting enzyme 2 (ACE2) receptor, the spike protein enables the virus to attach to the cell membrane, and plays a critical role in viral entry (Hoffmann <i>et al.</i>; Walls <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM:
1 * 1 PE
New Product
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
Numéro de catalogue:
(STMC100-1405)
Fournisseur:
STEMCELL Technologies
Description:
Stimulating T cells with CMV (UL44) peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. CMV (UL44) peptide pool is a lyophilised mixture of 106 peptides from DNA polymerase processivity factor UL44 of human cytomegalovirus (CMV; strain AD169), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 433 on UL44. UL44 contains a nuclear localization signal (Alvisi <i>et al.</i>) and may bind DNA directly, or form a C clamp partially surrounding it, similar to proliferation cell nuclear antigen (PCNA) (Appleton <i>et al.</i>). UL44 has also been found to interact with viral (Kim and Ahn) and host (Strang <i>et al.</i>) proteins that contribute to viral DNA replication and efficient viral growth. Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.
UOM:
1 * 1 PE
New Product
Il s'agit d'un élément MarketSource. Des frais supplémentaires peuvent s'appliquer.
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