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Protéines et Peptides
Numéro de catalogue:
(PRSI92-558)
Fournisseur:
ProSci Inc.
Description:
CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumour necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodelling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerisation and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signallling cascades, including the NFκB, mitogen-activated protein kinases (MAPK), activating protein 1 (AP-1), and nuclear factor of activated T cells (NFATc1), resulting in the formation of multinucleated bone-resorbing osteoclasts. RANKL is widely expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoblast, mammary gland epithelial cells, prostate and pancreas.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-499)
Fournisseur:
ProSci Inc.
Description:
V-Set and Immunoglobulin Domain-Containing Protein 4 (VSIG4) is a 45-50 kDa macrophage-specific transmembrane glycoprotein that belongs to the B7 family-related protein and an Ig superfamily member. In contrast to the B7 family members which contain two IgG domains, VSIG4 contains one complete V-type Ig domain and a truncated C-type I g domain. VSIG4 is abundantly expressed in several fetal tissues. In adult tissues, the highest expression of VSIG4 is in lung and placenta. It is also expressed in resting macrophages. No VSIG4 expression appears to be present in T and B cells. The specific expression of VSIG4 on resting macrophages in tissue suggests that this inhibitory ligand may be important for the maintenance of T cell unresponsiveness in healthy tissues. VSIG4 functions as a negative regulator of T cell activation, and may be involved in the maintenance of peripheral T cell tolerance, and is also identified as a potent suppressor of established inflammation. VSIG4 is a phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. It is a potent inhibitor of the alternative complement pathway convertases. Human VSIG4 is 399 amino acids (aa) in length. It is a type I transmembrane (TM) glycoprotein that contains a 264 aa extracellular domain (ECD) (aa 20 - 283) and a 95 aa cytoplasmic region.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-501)
Fournisseur:
ProSci Inc.
Description:
Adiponectin is a secreted protein. It is synthesized exclusively by adipocytes and secreted into plasma. Adiponectin is an important adipokine that is involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Adiponectin Stimulates AMPK phosphorylation and activates in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Adiponectin also antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. It inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. Adiponectin may play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex: LMW, MMW or HMW.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-502)
Fournisseur:
ProSci Inc.
Description:
Anterior Gradient Protein 2(AG-2) and Anterior Gradient Protein 3 (AG-3) are human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan (hAG-3 protein). AG-3 could serve as a prognostic marker for survival in patients with low grade and high grade serous ovarian carcinomas.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3779P)
Fournisseur:
ProSci Inc.
Description:
Beta-actin peptide is used for blocking the activity of beta-actin antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7435P)
Fournisseur:
ProSci Inc.
Description:
19 amino acids near the center of Heartland Virus Glycoprotein 2.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2299P)
Fournisseur:
ProSci Inc.
Description:
DcR1 peptide is used for blocking the activity of DcR1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6541P)
Fournisseur:
ProSci Inc.
Description:
TGM7 peptide is used for blocking the activity of TGM7 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6523P)
Fournisseur:
ProSci Inc.
Description:
ECRG2 peptide is used for blocking the activity of ECRG2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-393)
Fournisseur:
ProSci Inc.
Description:
High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses. HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI5929P)
Fournisseur:
ProSci Inc.
Description:
ApoA4 peptide is used for blocking the activity of ApoA4 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-675)
Fournisseur:
ProSci Inc.
Description:
Progonadoliberin-2, also known as Progonadoliberin II and GNRH2, belongs to the gonadotropin-releasing hormone family. GNRH2 is specially expressed in midbrain, at significantly higher levels outside the brain (up to 30-fold). GNRH2 can be cleaved into two chains, gonadoliberin-2 and GnRH-associated peptide 2. gonadoliberin-2 regulates reproduction in females by stimulating the secretion of both luteinizing- and follicle-stimulating hormones. The proproteins produce three transcript variants, but produce the same peptide hormone.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-540)
Fournisseur:
ProSci Inc.
Description:
Poliovirus Receptor (PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like (Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains, a transmembrane segment, and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms ( alpha, beta , gamma , and delta) with identical extracellular domains.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-546)
Fournisseur:
ProSci Inc.
Description:
Serum Amyloid A1 Protein (SAA1) is an acute phase apolipoprotein reactant that is produced predominantly by hepatocytes and is under the regulation of inflammatory cytokines. SAA is produced mainly in the liver and circulates in low levels in the blood. SAA may play a role in the immune system and facilitate the repair of injured tissues, it also acts as an antibacterial agent, and signals the migration of germ-fighting cells to sites of infection. SAA also functions as an apolipoprotein of the HDL complex. The SAA cleavage product designated amyloid protein A is deposited systemically as amyloid in vital organs such as the liver, spleen, and kidneys in chronic inflammatory diseases patients. These deposits are extremely insoluble and resistant to proteolysis; they disrupt tissue structure and compromise performance.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-085)
Fournisseur:
ProSci Inc.
Description:
Recombinant CD80 (from HEK293 cells)
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI91-987)
Fournisseur:
ProSci Inc.
Description:
Mitogen-Activated Protein Kinase Scaffold Protein 1 (MAPKSP1) was identified as an interacting protein that belongs to the LAMTOR3 family. MAPKSP1 restricted to late endosomes by the mitogen-activated protein-binding protein-interacting protein, and binds specifically to MAP kinase kinase MAP2K1/MEK1, MAP kinase MAPK3/ERK1, and MAP kinase MAPK1/ERK2. MAPKSP1 interacts with MAP2K1/MEK1 and MAPK2 and enhances the activation of MAPK2, and thus is thought to function as an adaptor to enhance the efficiency of the MAP kinase cascade.
UOM:
1 * 50 µG
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