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Antilichamen
Itemnummer:
(USBIC2400-21D)
Leverancier:
US Biological
Omschrijving:
Anti-PTPRC Mouse Monoclonal Antibody [clone: MEM-28]
UOM:
1 * 1 EA
Itemnummer:
(USBIC2400-10B)
Leverancier:
US Biological
Omschrijving:
Anti-PTPRC Mouse Monoclonal Antibody [clone: 9H217]
UOM:
1 * 1 EA
Itemnummer:
(USBIC2400-26RX)
Leverancier:
US Biological
Omschrijving:
Anti-CD45R Rat Monoclonal Antibody [clone: 5K284]
UOM:
1 * 500 µG
Itemnummer:
(USBIC2400-35A3)
Leverancier:
US Biological
Omschrijving:
Anti-CD45RA Mouse Monoclonal Antibody (PE (Phycoerythrin)/Cy5®) [clone: 5K285]
UOM:
1 * 1 EA
Leverancier:
Biotium
Omschrijving:
Recognizes a protein of 33-55 kDa, identified as CD53 (Workshop V; Code CD53.1). CD53 is expressed on monocytes, and macrophages, granulocytes, dendritic cells, osteoblasts and osteoclasts, NK cells, and on T- and B-cells from every stage of differentiation but is absent from platelets, erythrocytes, and non-haemopoietic cells. CD53 is a member of a family of tetraspan transmembrane proteins, including CD9, CD37, CD63, CD81, and CD82. It associates with integrins, MHC class II molecules, and a tyrosine phosphatase and plays a role in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. Defects of CD53 expression on neutrophils appear to be related with recurrent infectious diseases. Cross-linking CD53 using CD53 antibodies led to cytoplasmic calcium fluxes in B cells, monocytes, and granulocytes and activation of the monocyte oxidative burst.
Itemnummer:
(BNUM1029-50)
Leverancier:
Biotium
Omschrijving:
This antibody reacts with Ig domain of CD47 protein. CD47, originally named integrin-associated protein (IAP), is a 50 kDa protein containing five membrane-spanning sequences and a short cytoplasmic tail. CD47 plays a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It is important in memory formation and synaptic plasticity in the hippocampus. CD47 may play a role in membrane transport and/or integrin dependent signal transduction.
UOM:
1 * 50 µl
Itemnummer:
(BSBTBA1022-0.5)
Leverancier:
BosterBio
Omschrijving:
Anti-IgM Antibody (Biotin)
UOM:
1 * 0,5 mg
Itemnummer:
(BSBTBA1025-0.5)
Leverancier:
BosterBio
Omschrijving:
Anti-Protein A Antibody (Biotin)
UOM:
1 * 0,5 mg
Itemnummer:
(BOSSBS-7795R)
Leverancier:
Bioss
Omschrijving:
This gene encodes a membrane-bound glycoprotein from thefamily of dipeptidases involved in hydrolytic metabolism of variousdipeptides, including penem and carbapenem beta-lactam antibiotics.This gene is located on chromosome 16 in a cluster with anothermember of this family. Alternatively spliced transcript variantsthat encode different isoforms have been found for this gene.[provided by RefSeq, Jul 2008].
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-7809R)
Leverancier:
Bioss
Omschrijving:
LRRC62 contains 1 fibronectin type III domain and 5 LRR (leucine rich) repeats. The exact function of LRRC62 remains unknown.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-8590R)
Leverancier:
Bioss
Omschrijving:
Importin 7 is a 1,038 amino acid protein encoded by the human gene IPO7. Importin-7 belongs to the importin b family and contains one importin N-terminal domain. Importin-7 functions in nuclear protein import, either by acting as an autonomous nuclear transport receptor or as an adapter-like protein in association with the Importin b subunit KPNB1. Acting autonomously, Importin-7 is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to Importin-7, the Importin-7/substrate complex dissociates and Importin-7 is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. Importin-7 is a nuclear protein that is expressed in most tissues.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-8593R)
Leverancier:
Bioss
Omschrijving:
Glucosylceramide synthase (GCS), also designated ceramide glucosyltransferase, belongs to the glycosyltransferase 2 family. It is a widely expressed integral membrane protein encoded by UGCG. The enzyme can be found in the plasma membrane of all eukaryotic cells, and a significant concentration of glucosylceramide synthase activity has been reported in the Golgi complex. Glucosylceramide synthase catalyzes the first glycosylation step in glycosphingolipid biosynthesis and functions as a glucosyltransferase and flippase in the transfer of glucose to ceramide. Glucosylceramide synthase operates in cell recognition, cell proliferation and differentiation, immune recognition and signal transduction. The regulation of ceramide levels through glucosylceramide synthase has been associated with the induction of apoptosis and notable research implicates this relationship with drug-induced apoptosis in a variety of cell types.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-8577R)
Leverancier:
Bioss
Omschrijving:
GPKOW is a potential RNA-binding protein consisting of one central G patch domain and two C-terminal KOW domains. T54 is a 476 amino acid protein belonging to the MOS2 family. It is a mammalian homolog of the Arabidopsis thaliana MOS2 (modifier of SNC1, 2) nuclear protein that is required for innate immunity. Similar to A. thaliana MOS2, T54 localizes to the nucleus and contains G patch and KOW domains, suggesting that T54 may play a similar role in mammalian innate immunity.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-8579R)
Leverancier:
Bioss
Omschrijving:
The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-8005R)
Leverancier:
Bioss
Omschrijving:
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.
UOM:
1 * 100 µl
Itemnummer:
(BOSSBS-8015R)
Leverancier:
Bioss
Omschrijving:
This gene encodes a protein with an N-terminal RCC1 domain and a C-terminal BTB (broad complex, tramtrack and bric-a-brac) domain. In rat, over-expression of this gene in vascular smooth muscle cells induced cellular hypertrophy. In rat, the C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this gene maps to a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and other lymphoid malignancies. [provided by RefSeq, Jul 2008].
UOM:
1 * 100 µl
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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