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Eiwitten en peptiden
Itemnummer:
(PRSI91-889)
Leverancier:
ProSci Inc.
Omschrijving:
Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) is a single-pass type I membrane protein belonging to the LAMP family. LAMP1 is expressed largely in the endosome-lysosome membranes of cells.It shuttles between lysosomes, endosomes, and the plasma membrane. LAMP1 functions to present carbohydrate ligands to selectins and it has also been implicated in tumor cell metastasis. It has been proposed LAMP1 can be used as a therapeutic agent for certain cancers, as well as a marker for lysosomal storage disorders and degranulation on lymphocytes such as CD8+ and NK cells. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells(PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-451)
Leverancier:
ProSci Inc.
Omschrijving:
IL2RG contains one fibronectin type-III domain. IL2RG is an important signalling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. IL2RG interacts with SHB upon interleukin stimulation and HTLV-1 accessory protein p12I. Defects in IL2RG are the cause of X-linked combined immunodeficiency (XCID) and severe combined immunodeficiency X-linked T-cell-negative /B-cell-positive / NK-cell-negative (XSCID).
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-892)
Leverancier:
ProSci Inc.
Omschrijving:
Mouse vascular endothelial growth factor D, (VEGFD) is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. VEGFD is a secreted protein and highly expressed in fetal and adult lung. It undergoes a complex proteolytic maturation, generating multiple processed forms that bind and activate VEGFR-2 and VEGFR-3 receptors. The structure and function of this protein is similar to VEGFC. VEGFD is growth factor which active in angiogenesis, lymphangiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-453)
Leverancier:
ProSci Inc.
Omschrijving:
Parathyroid hormone/parathyroid hormone-related peptide receptor also known as parathyroid hormone 1 receptor (PTH1R) is a protein that in humans is encoded by the PTH1R gene, Belongs to the G-protein coupled receptor 2 family.PTH1R functions as a receptor for parathyroid hormone (PTH) and for parathyroid hormone-related protein (PTHrP), also called parathyroid hormone-like hormone (PTHLH).
UOM:
1 * 50 µG
Itemnummer:
(PRSI5969P)
Leverancier:
ProSci Inc.
Omschrijving:
NALP11 peptide is used for blocking the activity of NALP11 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5949P)
Leverancier:
ProSci Inc.
Omschrijving:
NOD3 peptide is used for blocking the activity of NOD3 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5957P)
Leverancier:
ProSci Inc.
Omschrijving:
NALP4 peptide is used for blocking the activity of NALP4 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-994)
Leverancier:
ProSci Inc.
Omschrijving:
Partner of Y14 and Mago (WIBG) is a key regulator of the Exon Junction Complex (EJC). EJC is a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs, is a positional landmarker for the intron exon structure of genes, and directs post-transcriptional processes in the cytoplasm, for instance mRNA export, nonsense-mediated mRNA decay or translation. WIBG is a cytoplasmic RNA-binding protein, it can be excluded from nucleus by Crm1. WIBG as a cooperateing partner of Mago-14, relates with Mago-14 by its N-terminal domain.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-217)
Leverancier:
ProSci Inc.
Omschrijving:
Zinc Finger and BTB Domain-Containing Protein 17 (ZBTB17) belongs to the Kruppel C2H2-type zinc finger protein family. ZBTB17 may function as a housekeeping DNA-binding protein that regulates the expression of specific genes, it has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. ZBTB17 may has growth arrest activity, probably through inhibition of cell cycle progression. ZBTB17 required for early embryonic development during gastrulation. ZBTB17 induces cell arrest at G1, an effect mediated by its activation of the gene coding for P15INK4b. This effect is blocked by Myc, which displaces transcriptional coactivators bound to ZBTB17. Although the downregulation of ZBTB17 may contribute to Myc-induced cell transformation, the de-activation of ZBTB17 is absolutely essential for Myc-induced apoptosis.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-602)
Leverancier:
ProSci Inc.
Omschrijving:
High temperature requirement protein A2(HTRA2) is a single-pass membrane protein .It contains 1 PDZ (DHR) domain and belongs to the peptidase S1C family. HtrA2 can be released from the mitochondria during apoptosis and uses its four most N-terminal amino acids to mimic a caspase and be recruited by IAP caspase inhibitors such as XIAP and CIAP1/2. It promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. The protein cleaves THAP5 and promotes its degradation during apoptosis.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-054)
Leverancier:
ProSci Inc.
Omschrijving:
The Galectin family of proteins (with specificity for Nacetyllactosamine containing glycoproteins) consists of beta-galactoside binding lectins containing homologous carbohydrate recognition domains (CRDs). At least 14 mammalian galectins family members that share structural similarities in their carbohydrate recognition domains (CRD) have been identified to date. Unlike the selectin family of proteins, the carbohydrate binding specificity of galectins is calcium-independent. A common function of galectins is to cross-link structures containing N-acetyl-lactosamine located at the cell surface and within the extracellular matrix. They also possess hemagglutination activity, which is attributable to their bivalent carbohydrate binding properties. Galectins are active both intracellularly and extracellularly. They have diverse effects on many cellular functions including adhesion, migration, polarity, chemotaxis, proliferation, apoptosis, and differentiation. Galectins may therefore play a key role in many pathological states, including autoimmune diseases, allergic reactions, inflammation, tumor cell metastasis, atherosclerosis, and diabetic complications. The galectins have been classified into the prototype galectins (1, 2, 5, 7, 10, 11, 13, 14), which contain one CRD and exist either as a monomer or a noncovalent homodimer. The chimera galectins (Galectin3) containing one CRD linked to a nonlectin domain, and the tandem repeat Galectins (4, 6, 8, 9, 12) consisting of two CRDs joined by a linker peptide. Galectins lack a classical signal peptide and can be localized to the cytosolic compartments where they have intracellular functions. However, via one or more as yet unidentified nonclassical secretory pathways, galectins can also be secreted to function extracellularly. Individual members of the galectin family have different tissue distribution profiles and exhibit subtle differences in their carbohydrate-binding specificities. Each family member may preferentially bind to a unique subset of cell surface glycoproteins.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5097P)
Leverancier:
ProSci Inc.
Omschrijving:
ApoA1 peptide is used for blocking the activity of ApoA1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4335P)
Leverancier:
ProSci Inc.
Omschrijving:
Strep-tag II peptide is used for blocking the activity of strep-tag II antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3229P)
Leverancier:
ProSci Inc.
Omschrijving:
ACE2 peptide is used for blocking the activity of ACE2 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6917P)
Leverancier:
ProSci Inc.
Omschrijving:
SARM peptide is used for blocking the activity of SARM antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6901P)
Leverancier:
ProSci Inc.
Omschrijving:
STOX1 peptide is used for blocking the activity of STOX1 antibody.
UOM:
1 * 50 µG
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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