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Eiwitten en peptiden
Itemnummer:
(PRSI90-344)
Leverancier:
ProSci Inc.
Omschrijving:
CREB-binding protein acetylates histones, giving a specific tag for transcriptional activation. It also acetylates non-histone proteins, like NCOA3 and FOXO1. It binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.
UOM:
1 * 2 µG
Itemnummer:
(PRSI90-348)
Leverancier:
ProSci Inc.
Omschrijving:
NF-kappaB is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappaB is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric p65-p50 complex is the most abundant complex. The dimers bind at kappaB sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappaB sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappaB complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappaB inhibitor (I-kappaB) family. In a conventional activation pathway, I-kappaB is phosphorylated by I-kappaB kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappaB complex which translocates to the nucleus. NF-kappaB heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappaB p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappaB complex.
UOM:
1 * 2 µG
Itemnummer:
(PRSI4801P)
Leverancier:
ProSci Inc.
Omschrijving:
Akirin1 peptide is used for blocking the activity of Akirin1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4793P)
Leverancier:
ProSci Inc.
Omschrijving:
ACVR1B peptide is used for blocking the activity of ACVR1B antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-534)
Leverancier:
ProSci Inc.
Omschrijving:
EGF-Like Repeat and Discoidin I-Like Domain-Containing Protein 3 (EDIL3) is a 52 kDa extracellular matrix protein that is expressed by endothelial tissues during embryonic vascular development. EDIL3 becomes quiescent at the time of birth, and is no longer expressed in normal adult tissues. EDIL3 has been found to be re-expressed in a number of human tumors as well as in ischemic muscles and ischemic brain tissue, which may play an important role in adult angiogenesis. EDIL3 promotes adherence and migration of endothelial cells, and acts as an endothelial cell survival agent through upregulation of Bcl-2 expression. EDIL3 has also been shown to be an endogenous inhibitor of inflammatory cell recruitment by interfering with the integrin LFA-1-dependent leukocyte-endothelial adhesion. Human EDIL3 is synthesized as a precursor with a 16 amino acid signal sequence and a 464 amino acid mature chain.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6437P)
Leverancier:
ProSci Inc.
Omschrijving:
LY6K peptide is used for blocking the activity of LY6K antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-715)
Leverancier:
ProSci Inc.
Omschrijving:
Sialidase-1 belongs to the N-acetyl-a neuraminidase family. Sialidase-1 is expressed in many tissues; it is highly expressed in the pancreas, and weakly expressed in the brain. Sialidase-1 is a lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. Deficiencies in the human enzyme Sialidase-1 leads to sialidosis, a rare lysosomal storage disease. Sialidase-1 has been shown to interact with Cathepsin A (protective protein), beta -galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-164)
Leverancier:
ProSci Inc.
Omschrijving:
Ubiquitin-Conjugating Enzyme E2 D4 (UBE2D4) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2D4 has been proposed to participate in Ubl conjugation pathway. UBE2D4 takes part in post-translational protein modification, protein K6-linked ubiquitination, protein K11-linked ubiquitination, protein K27-linked ubiquitination, protein K29-linked ubiquitination, protein K48-linked ubiquitination, and protein K63-linked ubiquitination. UBE2D4 regulate of protein metabolic process. UBE2D4 accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, UBE2D4 able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked poly-ubiquitination.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-708)
Leverancier:
ProSci Inc.
Omschrijving:
MANSC domain-containing protein 1(MANSC1) is encoded by MANSC1 gene. MANSC1 is a Single-pass type I membrane protein which contains 1 MANSC domain. It is widely expressed in many tissues and mainly located in membrane.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-305)
Leverancier:
ProSci Inc.
Omschrijving:
Flagellin is the subunit protein which polymerises to form the filaments of bacterial flagella. It activates the innate immune system through the receptor Toll-like Receptor 5 (TLR5) and the intracellular protein NLRC4 (NLR family CARD domain-containing protein 4).
UOM:
1 * 1 EA
Itemnummer:
(PRSI90-313)
Leverancier:
ProSci Inc.
Omschrijving:
Wnts are lipid-modified morphogens that control many processes during development, stem cell maintenance and homeostasis and their aberrant regulation has been linked to diseases in man including diabetes, neurodegeneration and cancer. Three distinct receptor families mediate Wnt signalling: Fzs, the single-pass LRP5/6 co-receptors and the atypical tyrosine kinase receptors Ror2 and Ryk. Frizzled proteins can activate canonical Wnt/beta-catenin signalling as well as non-canonical pathways (Wnt/Ca2+ pathways and planar cell polarity). The cysteine-rich domain (CRD) of the frizzled receptors situated on the extracellular part of the receptor is sufficient to bind the Wnt ligands.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5443P)
Leverancier:
ProSci Inc.
Omschrijving:
GOLPH3 peptide is used for blocking the activity of GOLPH3 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI2253P)
Leverancier:
ProSci Inc.
Omschrijving:
BACE peptide is used for blocking the activity of BACE antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-660)
Leverancier:
ProSci Inc.
Omschrijving:
Galectin-3(LGALS3) is also known as Galactose-specific lectin 3, Mac-2 antigen, Carbohydrate-binding protein 35, Laminin-binding protein and Galactoside-binding protein. LGALS3 is highly expressed in early stages of papillary carcinoma, and lowly during tumor progression. LGALS3 is probably forms homo- or heterodimers and secreted by a non-classical secretory pathway and associates with the cell surface. LGALS3 plays an important role during the acquisition of vasculogenic mimicry and angiogenic properties. LGLAS3 takes part in an immune regulator to inhibit T-cell immune responses and promote tumor growth, as a result providing a new mechanism for tumor immune tolerance.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3017P)
Leverancier:
ProSci Inc.
Omschrijving:
ILP-2 peptide is used for blocking the activity of ILP-2 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3005P)
Leverancier:
ProSci Inc.
Omschrijving:
MAP1 peptide is used for blocking the activity of the MAP-1 antibody.
UOM:
1 * 1 EA
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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