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Eiwitten en peptiden
Itemnummer:
(PRSI3341P)
Leverancier:
ProSci Inc.
Omschrijving:
Bcl-xL peptide is used for blocking the activity of Bcl-xL antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3351P)
Leverancier:
ProSci Inc.
Omschrijving:
Bax peptide is used for blocking the activity of Bax antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3309P)
Leverancier:
ProSci Inc.
Omschrijving:
BRUCE peptide is used for blocking the activity of BRUCE antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3319P)
Leverancier:
ProSci Inc.
Omschrijving:
OMI peptide is used for blocking the activity of Anit-OMI antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-259)
Leverancier:
ProSci Inc.
Omschrijving:
Neuritin/NRN1 is a member of the neuritin family and can be expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. Neuritin/NRN1 promotes neurite outgrowt， arborisation and neuritogenesis. The protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins.Overexpression of the encoded protein may be associated with astrocytoma progression.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-260)
Leverancier:
ProSci Inc.
Omschrijving:
Complement component C8 is a constituent of the membrane attack complex, C8 alpha, C8 beta and C8G. C8G is a secreted protein and comsists a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 alpha and C8 beta play an important role in complement-mediated bacterial killing together.C8 is involved in the formation of Membrane Attack Complex on bacterial cell membranes. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerisation of C9. The gamma subunit seems to be able to bind retinol. Patients lacking C8 are susceptible to certain bacterial infections.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-261)
Leverancier:
ProSci Inc.
Omschrijving:
Alpha-Synuclein (SNCA) is a member of the Synuclein family. SNCA is expressed principally in brain but also expressed in low concentrations in all tissues except liver. SNCA interacts with UCHL1, Phospholipase D and histones. SNCA can include beta- and gamma-synuclein. In addition, SNCA is an important regulatory component of vesicular transport in neuronal cells. It has been suggested that SNCA is related to the pathogenesis of Parkinson's Disease and neurodegenerative disorders. Defects in SNCA will lead to Dementia Lewy Body (DLB).
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-556)
Leverancier:
ProSci Inc.
Omschrijving:
Zymogen Granule Membrane Protein 16 (ZG16) belongs to the jacalin lectin family. ZG16 is highly expressed in liver and is detected at lower levels in colon, ileum and jejunum. ZG16 may play a role in protein trafficking. In addition, ZG16 may act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5303P)
Leverancier:
ProSci Inc.
Omschrijving:
ABIN3 peptide is used for blocking the activity of ABIN3 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5299P)
Leverancier:
ProSci Inc.
Omschrijving:
TMEM214 peptide is used for blocking the activity of TMEM214 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5305P)
Leverancier:
ProSci Inc.
Omschrijving:
TWA1 peptide is used for blocking the activity of TWA1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-488)
Leverancier:
ProSci Inc.
Omschrijving:
Interleukin 6 receptor (IL-6R; CD126) is a type I cytokine receptor, which is a protein complex consisting of an IL-6 receptor subunit (IL-6R) and interleukin 6 signal transducer glycoprotein 130 (gp130). It is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL-6 and IL-6R are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-218)
Leverancier:
ProSci Inc.
Omschrijving:
Human TNFSF10 is a type II transmembrane protein with an intracellular N-terminus and a ‘TNF homology domain’ (THD) at the extracellular C terminus. TNFSF10 can interact with several distinct receptors. Two of these receptors that belongs to TNFR superfamily, DR4 (TRAIL-R1) and DR5 (TRAIL-R2/TRICK2), are plasma membrane proteins containing intracellular death domains essential for activating apoptosis. TNFSF10 is promising for cancer therapy because it is cytotoxic and activates apoptosis in the majority of malignant cells, but not in normal cells.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-210)
Leverancier:
ProSci Inc.
Omschrijving:
LMCD1 is transcriptional cofactor which contains a cysteine-rich domain in the N-terminal region and 2 LIM domains in the C-terminal region. It also has several potential phosphorylation and N-myristoylation sites and a single potential N-glycosylation site. LMCD1 is expressed in many tissues with highest abundance in skeletal muscle. LMCD1 restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. It plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signalling pathway.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-460)
Leverancier:
ProSci Inc.
Omschrijving:
The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
UOM:
1 * 1 EA
Itemnummer:
(PRSI40-610)
Leverancier:
ProSci Inc.
Omschrijving:
TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein. Recombinant rat TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein.
UOM:
1 * 1 EA
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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