Eiwitten en peptiden
Itemnummer:
(PRSI92-522)
Leverancier:
ProSci Inc.
Omschrijving:
Mouse Interleukin 36 beta (IL-36B)is a member of the IL-1 family of proteins. It is a cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signalling pathways in target cells linked to a pro-inflammatory response. IL-36B is synthesised in several cells including resting and activated monocytes, and B cells. The receptor for IL-36 beta is thought to be a combination of IL-1 Rrp2 and IL-1 RAcP. Interleukin 36 beta is one part of the IL-36 signalling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Interleukin 36 beta are involved in a number of fundamental biological processes such as stimulating production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes, inducing expression of a number of antimicrobial peptides including beta-defensin 4 and beta-defensin 103 as well as a number of matrix metalloproteases , inducing the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23, and activating p38 MAPK phosphorylation in BMDCs.Moreover, interleukin 36 beta may be involved in skin inflammatory response by acting on keratinocytes, dendritic cells, and indirectly on T cells to drive tissue infiltration, cell maturation and cell proliferation. It plays an important role in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II and inducing the production of IFN-gamma, IL-4 and IL-17 by T helper 1 (Th1) cells, cultured CD4+ T cells and splenocytes.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-116)
Leverancier:
ProSci Inc.
Omschrijving:
Human Fatty Acid-Binding Protein 1 (FABP1) is a cytoplasm protein, which belongs to the calycin superfamily and Fatty-acid binding protein (FABP) family. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids. FABP1 forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. FABP1 can bind free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm, so it can be involved in intracellular lipid transport.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-118)
Leverancier:
ProSci Inc.
Omschrijving:
Fatty Acid Binding Protein 3 (FABP3) is a small cytoplasmic protein (15 kDa) that is released from cardiac myocytes following an ischemic episode. Like the nine other distinct FABPs that have been identified, FABP3 is involved in active fatty acid metabolism where it transports fatty acids from the cell membrane to mitochondria for oxidation. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-types. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. The FABP3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is also a candidate tumor suppressor gene for human breast cancer. FABP3 is a sensitive biomarker for myocardial infarction and can be detected in the blood within one to three hours of onset of pain.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4215P)
Leverancier:
ProSci Inc.
Omschrijving:
ORAI3 peptide is used for blocking the activity of ORAI3 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6641P)
Leverancier:
ProSci Inc.
Omschrijving:
Rkhd3 peptide is used for blocking the activity of Rkhd3 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6625P)
Leverancier:
ProSci Inc.
Omschrijving:
EMX1 peptide is used for blocking the activity of EMX1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6605P)
Leverancier:
ProSci Inc.
Omschrijving:
Thymopoietin peptide is used for blocking the activity of Thymopoietin antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI2451P)
Leverancier:
ProSci Inc.
Omschrijving:
PERP peptide is used for blocking the activity of PERP antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI2471P)
Leverancier:
ProSci Inc.
Omschrijving:
IL-21 receptor peptide is used for blocking the activity of IL-21 receptor antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5669P)
Leverancier:
ProSci Inc.
Omschrijving:
NSA1 peptide is used for blocking the activity of NSA1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-949)
Leverancier:
ProSci Inc.
Omschrijving:
It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs. The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of the encoded protein can trigger apoptosis. Not only does the TNFRSF3 help trigger apoptosis, it can lead to the release of the cytokine interleukin 8. Overexpression of TNFRSF3 in Human Cells cells increases IL-8 promoter activity and leads to IL-8 release. TNFRSF3 is also essential for development and organization of the secondary lymphoid organs and chemokine release.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6087P)
Leverancier:
ProSci Inc.
Omschrijving:
ZIP4 peptide is used for blocking the activity of ZIP4 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4573P)
Leverancier:
ProSci Inc.
Omschrijving:
NPTX2 peptide is used for blocking the activity of NPTX2 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4557P)
Leverancier:
ProSci Inc.
Omschrijving:
Ambra1 peptide is used for blocking the activity of Ambra1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4555P)
Leverancier:
ProSci Inc.
Omschrijving:
Ambra1 peptide is used for blocking the activity of Ambra1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4571P)
Leverancier:
ProSci Inc.
Omschrijving:
ELOVL6 peptide is used for blocking the activity of ELOVL6 antibody.
UOM:
1 * 50 µG
Bel voor prijs
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De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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