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Eiwitten en peptiden
Itemnummer:
(PRSI92-116)
Leverancier:
ProSci Inc.
Omschrijving:
Interleukin-3 (IL-3) is a potent growth promoting cytokine. IL-3 can stimulate the proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. IL-3 exerts its biological function through binding to specific cell surface receptors. The amino acid sequences of this protein among different species share relatively low identity and its activity is highly species-specific. IL-3 has also been shown to possess neurotrophic activity, and is thought to be associated with neurologic disorders.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3147P)
Leverancier:
ProSci Inc.
Omschrijving:
PHAP III peptide is used for blocking the activity of PHAP III antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3155P)
Leverancier:
ProSci Inc.
Omschrijving:
TIRAP peptide is used for blocking the activity of TIRAP antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3149P)
Leverancier:
ProSci Inc.
Omschrijving:
PHAP peptide is used for blocking the activity of PHAP antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3035P)
Leverancier:
ProSci Inc.
Omschrijving:
EndoG peptide is used for blocking the activity of EndoG antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-217)
Leverancier:
ProSci Inc.
Omschrijving:
tumour Necrosis Factor- alpha (TNF- alpha) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressing CD4 secrete TNF- alpha while cells that express CD8 secrete little or no TNF- alpha. Synthesis of TNF- alpha can be induced by many different stimuli including interferons, IL2, and GM-CSF. The clinical use of the potent anti-tumour activity of TNF- alpha has been limited by the proinflammatory side effects such as fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF- alpha mutants with low systemic toxicity has been of intense pharmacological interest. Human TNF- alpha that binds to murine TNF-R55 but not murine TNF-R7, exhibits retained anti-tumour activity and reduced systemic toxicity in mice compared with murine TNF- alpha, which binds to both murine TNF receptors. Based on these results, many TNF- alpha mutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumour cell lines in vitro and have exhibited lower systemic toxicity in vivo. Recombinant Human TNF- alpha High Active Mutant differs from the wild-type by amino acid subsitution of amino acids 1-7 with Arg8, Lys9, Arg10 and Phe157. This mutant form has been shown to have increased activity with less inflammatory side effects in vivo.
UOM:
1 * 50 µG
Itemnummer:
(PRSI96-066)
Leverancier:
ProSci Inc.
Omschrijving:
Butyrophilin subfamily 3 member A3 (BTN3A3),a member of the immunoglobulin superfamily and BTN/MOG family, is also known as BTF3, which contains one B30.2/SPRY domain and two Ig-like V-type (immunoglobulin-like) domains. BTN3A3 is detected in peripheral blood mononuclear cells ,T-cells ,spleen and lymphocytes. BTN3A3 also plays a role in T-cell responses in the adaptive immune response. Stimulation of human butyrophilin 3(BTN3) molecules results in negative regulation of cellular immunity.
UOM:
1 * 1 EA
Itemnummer:
(PRSI92-059)
Leverancier:
ProSci Inc.
Omschrijving:
Alpha-Crystallin A Chain (CRYAA) belongs to the small heat shock protein (HSP20) family and can be induced by heat shock. The expression of CRYAA is preferentially restricted to the lens cell. CRYAA may contribute to the transparency and refractive index of the lens. CRYAA has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Two additional functions of CRYAA are an autokinase activity and participation in the intracellular architecture.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-050)
Leverancier:
ProSci Inc.
Omschrijving:
Alpha-Parvin (PARVA) is a member of the Parvin family. PARVA contains two CH (calponin-homology) domains. PARVA is widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. PARVA interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. PARVA may play a role in the regulation of cell adhesion and cytoskeleton organization. PARVA is also involved in ciliogenesis.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-555)
Leverancier:
ProSci Inc.
Omschrijving:
Vascular Non-Inflammatory Molecule 2 (VNN2) is a member of the CN hydrolase family. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. they possess pantetheinase activity, which may play a role in oxidative-stress response. VNN2 is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. VNN2 involved in the thymus homing of bone marrow cells. In addition, VNN2 may regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-118)
Leverancier:
ProSci Inc.
Omschrijving:
Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumourigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition, PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. At present, PEA15 expression is also a significant prognostic marker in ovarian cancer.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5309P)
Leverancier:
ProSci Inc.
Omschrijving:
PGCC1 peptide is used for blocking the activity of PGCC1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5307P)
Leverancier:
ProSci Inc.
Omschrijving:
FAM120A peptide is used for blocking the activity of FAM120A antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5291P)
Leverancier:
ProSci Inc.
Omschrijving:
NOTUM peptide is used for blocking the activity of NOTUM antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-120)
Leverancier:
ProSci Inc.
Omschrijving:
Fatty acid-binding protein 5 (FABP5) is a cytoplasm protein that belongs to the fatty-acid binding protein (FABP) family of calycin superfamily. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids. FABP5 can be expressed in keratinocytes, and is highly expressed in psoriatic skin. FABP5 has been shown to be involved in keratinocyte differentiation. FABP5 has high specificity for fatty acids, the highest affinity for C18 chain length. FABP5 can decrease the chain length or introduce double bonds to reduce the affinity.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-155)
Leverancier:
ProSci Inc.
Omschrijving:
The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network. DLL4-Notch1 signalling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.
UOM:
1 * 50 µG
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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