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Eiwitten en peptiden
Itemnummer:
(PRSI92-390)
Leverancier:
ProSci Inc.
Omschrijving:
Myelin protein zero-like protein 1(MPZL1) is encoded by the MPZL1 gene, which is a single-pass type I membrane protein. It is widely expressed with highest levels in heart, placenta, kidney and pancreas. As cell surface receptor, it involved in signal transduction processes. MPZL1 recruits PTPN11/SHP-2 to the cell membrane and subsequently activate/phosphorylate Src kinase at Tyr426, promoting phosphorylation of cortactin and migration of HCC cells. MPZL1also is a major receptor for concanavalin-A (ConA) and involved in cellular signalling induced by ConA, which probably includes Src family tyrosine-protein kinases.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4703P)
Leverancier:
ProSci Inc.
Omschrijving:
NUP155 peptide is used for blocking the activity of NUP155 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-130)
Leverancier:
ProSci Inc.
Omschrijving:
Actin-Related Protein 8 (ACTR8) is a member of the Actin family. ACTR8 is the first example in actin family that was found to be associated with mitotic chromosomes. ACTR8 plays a vital role in the functional organisation of mitotic chromosomes. This protein is a proposed core component of the chromatin remodelling INO80 complex that is involved in transcriptional regulation, DNA replication and probable DNA repair, and it is required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-217)
Leverancier:
ProSci Inc.
Omschrijving:
tumour Necrosis Factor- alpha (TNF- alpha) is secreted by macrophages, monocytes, neutrophils, T-cells, and NK-cells following stimulation by bacterial LPS. Cells expressing CD4 secrete TNF- alpha while cells that express CD8 secrete little or no TNF- alpha. Synthesis of TNF- alpha can be induced by many different stimuli including interferons, IL2, and GM-CSF. The clinical use of the potent anti-tumour activity of TNF- alpha has been limited by the proinflammatory side effects such as fever, dose-limiting hypotension, hepatotoxicity, intravascular thrombosis, and hemorrhage. Designing clinically applicable TNF- alpha mutants with low systemic toxicity has been of intense pharmacological interest. Human TNF- alpha that binds to murine TNF-R55 but not murine TNF-R7, exhibits retained anti-tumour activity and reduced systemic toxicity in mice compared with murine TNF- alpha, which binds to both murine TNF receptors. Based on these results, many TNF- alpha mutants that selectively bind to TNF-R55 have been designed. These mutants displayed cytotoxic activities on tumour cell lines in vitro and have exhibited lower systemic toxicity in vivo. Recombinant Human TNF- alpha High Active Mutant differs from the wild-type by amino acid subsitution of amino acids 1-7 with Arg8, Lys9, Arg10 and Phe157. This mutant form has been shown to have increased activity with less inflammatory side effects in vivo.
UOM:
1 * 50 µG
Itemnummer:
(PRSI96-066)
Leverancier:
ProSci Inc.
Omschrijving:
Butyrophilin subfamily 3 member A3 (BTN3A3),a member of the immunoglobulin superfamily and BTN/MOG family, is also known as BTF3, which contains one B30.2/SPRY domain and two Ig-like V-type (immunoglobulin-like) domains. BTN3A3 is detected in peripheral blood mononuclear cells ,T-cells ,spleen and lymphocytes. BTN3A3 also plays a role in T-cell responses in the adaptive immune response. Stimulation of human butyrophilin 3(BTN3) molecules results in negative regulation of cellular immunity.
UOM:
1 * 1 EA
Itemnummer:
(PRSI92-246)
Leverancier:
ProSci Inc.
Omschrijving:
Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon- gamma (IFN- gamma ) or type II interferon that plays an important role in activating the macrophages or other cells.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3147P)
Leverancier:
ProSci Inc.
Omschrijving:
PHAP III peptide is used for blocking the activity of PHAP III antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3155P)
Leverancier:
ProSci Inc.
Omschrijving:
TIRAP peptide is used for blocking the activity of TIRAP antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3149P)
Leverancier:
ProSci Inc.
Omschrijving:
PHAP peptide is used for blocking the activity of PHAP antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3453P)
Leverancier:
ProSci Inc.
Omschrijving:
Caspase-4 peptide is used for blocking the activity of caspase-4 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-104)
Leverancier:
ProSci Inc.
Omschrijving:
Stromal Cell-Derived Factor-1 (SDF-1) is a chemokine member of the intercrine family. SDF1 is expressed as five isoforms that differ only in the C terminal tail. SDF1 alpha and SDF1 beta are identical except for the four residues present in the C-terminus of SDF1 beta but absent from SDF1 alpha. SDF1 isoforms interact with CXCR4 and CXCR7 receptors on the cell surface, and can also bind syndecan4. SDF1 is known to influence lymphopoiesis, regulate patterning and cell number of neural progenitors, and promote angiogenesis. It also enhances the survival of myeloid progenitor cells.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4753P)
Leverancier:
ProSci Inc.
Omschrijving:
NENF peptide is used for blocking the activity of NENF antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-059)
Leverancier:
ProSci Inc.
Omschrijving:
Alpha-Crystallin A Chain (CRYAA) belongs to the small heat shock protein (HSP20) family and can be induced by heat shock. The expression of CRYAA is preferentially restricted to the lens cell. CRYAA may contribute to the transparency and refractive index of the lens. CRYAA has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Two additional functions of CRYAA are an autokinase activity and participation in the intracellular architecture.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-050)
Leverancier:
ProSci Inc.
Omschrijving:
Alpha-Parvin (PARVA) is a member of the Parvin family. PARVA contains two CH (calponin-homology) domains. PARVA is widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. PARVA interacts with integrin-linked protein kinase and probably with actin and the LD1 and LD4 motifs of PXN. PARVA may play a role in the regulation of cell adhesion and cytoskeleton organization. PARVA is also involved in ciliogenesis.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5051P)
Leverancier:
ProSci Inc.
Omschrijving:
RCAN2 peptide is used for blocking the activity of RCAN2 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3035P)
Leverancier:
ProSci Inc.
Omschrijving:
EndoG peptide is used for blocking the activity of EndoG antibody.
UOM:
1 * 50 µG
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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