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Eiwitten en peptiden
Itemnummer:
(PRSI91-262)
Leverancier:
ProSci Inc.
Omschrijving:
Z-DNA Binding Protein 1 (ZBP1) is a protein with 2 DRADA repeats. ZBP1 is highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow, and spleen. ZBP1 participates in the detection of viral and bacterial DNA from by the host's innate immune system. It plays a role in host defense against tumors and pathogens. ZBP1 Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-559)
Leverancier:
ProSci Inc.
Omschrijving:
Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumour necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signallling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodellling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutively expressed in skeletal muscle, thymus, liver, colon, small intestine, adrenal gland, osteoclast, mammary gland epithelial cells, prostate, vascular cell, and pancreas.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-354)
Leverancier:
ProSci Inc.
Omschrijving:
Nuclear NMNAT isoform. Catalyses the formation of NAD+ from nicotinamide mononucleotide (NMN) and ATP. It can also use the deamidated form of nicotinic acid mononucleotide (NAMN) as substrate with the same efficiency. Interacts with PARP-1/ARTD1. Protects against axonal degeneration following mechanical or toxic insults. Widely expressed.
UOM:
1 * 1 EA
Itemnummer:
(PRSI91-346)
Leverancier:
ProSci Inc.
Omschrijving:
MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, tissue remodeling, and disease processes including arthritis and metastasis. The MMP-3 enzyme degrades collagen types II, III, IV, IX, and X, proteoglycans, fibronectin, laminin, and elastin. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7, and MMP-9, rendering MMP-3 crucial in connective tissue remodeling.[3] The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-355)
Leverancier:
ProSci Inc.
Omschrijving:
Secreted Protein Acidic and Rich in Cysteine (SPARC) is a secreted, evolutionarily conserved collagen-binding glycoprotein and belongs to the SPARC family. SPARC has 286 amino acids and contains an EF-hand in C-termina domain, a follistatin-like domain with Kazal-like sequences. There are two calcium binding sites, one binds 5 - 8 Ca2+ with a low affinity and other on an EF-hand loop that binds a Ca2+ ion with a high affinity. It is highly expressed in tissues undergoing morphogenesis, remodeling and wound repair. SPARC regulate cell growth through interactions with the extracellular matrix (ECM) and cytokines. SPARC bind to numerous proteins of the ECM, affect ECM protein expression, influence cellular adhesion and migration, and modulate growth factor-induced cell proliferation and angiogenesis. SPARC also binds several types of collagen, albumin, thrombospondin, PDGF and cell membranes.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5593P)
Leverancier:
ProSci Inc.
Omschrijving:
CALHM1 pepide is used for blocking the activity of CALHM1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-205)
Leverancier:
ProSci Inc.
Omschrijving:
Growth Arrest-Specific Protein 7 (GAS7) is expressed primarily in terminalaly differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 may play a role in neuronal development by promoting maturation and morphological differentiation of cerebellar neurons. Inhibition of GAS7 production in terminally differentiating cultures of embryonic murine cerebullum impedes neurite outgrowth. The hyper-expression of GAS7 may play an major role in the initiation and development of huaman osteosarcoma.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-203)
Leverancier:
ProSci Inc.
Omschrijving:
Fibroblast Growth Factor 21 (FGF21) is a growth factor that belongs to the FGF family. FGF family proteins play a central role during prenatal development and postnatal growth and regeneration of mamy tissues, by promoting cellular proliferation and differentiation. FGF21 is a potent activator of glucose uptake on adipocytes, protects animal from diet-induced obesity when overexpression in transgenic mice, and lower blood glucose and triglyceride levels when therapeutically adiministered to diabetic redents. FGF21 is produced by hepatocytes in reponse to free fatty acid stimulation of a PPARa/RXR dimeric complex. This situation occurs clinically during starvation, or following the ingestionof a highly-fat/low-carbohydrate diet.Upon FGF21 secretion, white adipose tissue is induced to release free fatty acids from triglyceride stores. Once free fatty acid reach hepatocytes, they are oxidized and reduced to acetyl-CoA. The acetyl-CoA is recombined into 4-carbon ketone bodies, release, and transported to peripheral tissue for TCA processing and energy generation.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6231P)
Leverancier:
ProSci Inc.
Omschrijving:
ZFP219 peptide is used for blocking the activity of ZFP219 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6249P)
Leverancier:
ProSci Inc.
Omschrijving:
SLAMF2 peptide is used for blocking the activity of SLAMF2 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6255P)
Leverancier:
ProSci Inc.
Omschrijving:
DYRK1A peptide is used for blocking the activity of DYRK1A antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6615P)
Leverancier:
ProSci Inc.
Omschrijving:
SPATA18 peptide is used for blocking the activity of SPATA18 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6607P)
Leverancier:
ProSci Inc.
Omschrijving:
ANKLE1 peptide is used for blocking the activity of ANKLE1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI2483P)
Leverancier:
ProSci Inc.
Omschrijving:
TCCR peptide is used for blocking the activity of TCCR antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-417)
Leverancier:
ProSci Inc.
Omschrijving:
Human Fractalkine (CX3CL1) is a member of the CX3C family of chemokines. Human Fractalkine contains both chemokine and mucin domain. The soluble form of Fractalkine is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane bound form of Fractalkine promotes leukocytes adhesion to endothelial cells. Fractalkine regulates leukocyte adhesion and migration processes at the endothelium and binds to CX3CR1. Natural Human Fractalkine is produced as a long protein (373-amino acid). The mucin-like stalk permits it to bind to the cell surface.
UOM:
1 * 50 µG
Itemnummer:
(PRSI1137P)
Leverancier:
ProSci Inc.
Omschrijving:
GFR alpha 3 peptide is used for blocking the activity of GFR alpha 3 antibody.
UOM:
1 * 50 µG
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
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