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Eiwitten en peptiden
Itemnummer:
(PRSI2345P)
Leverancier:
ProSci Inc.
Omschrijving:
TP1 peptide is used for blocking the activity of TP1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-227)
Leverancier:
ProSci Inc.
Omschrijving:
OX40 binds to receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. OX40 has a critical role in the maintenance of an immune response. OX40:Fc was shown to prevent OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Experiments in mice have demonstrated that OX40:Fc can reduce the symptoms associated with the cytokine storm (an immune overreaction) while allowing the immune system to fight off the virus successfully.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-237)
Leverancier:
ProSci Inc.
Omschrijving:
BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation . Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases, such as Sjögren’s syndrome , Rheumatoid Arthritis (RA) , Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE) . BAFF is also increased levels in some lymphoid cancers.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-631)
Leverancier:
ProSci Inc.
Omschrijving:
IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN- gamma ) and tumor necrosis factor-alpha (TNF- alpha) from T cells and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN- gamma . T cells that produce IL-12 have a coreceptor, CD30, which is associated with IL-12 activity. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-638)
Leverancier:
ProSci Inc.
Omschrijving:
Limitin, also called IFN-ζ, is a secreted interferon (IFN)-like glycoprotein. Limitin has approximately 30% sequence homology with IFN- alpha, IFN- beta , and IFN-ω and binds to the IFN- alpha/ beta receptors. Like IFN- alpha and IFN- beta , limitin has antiproliferative, immunomodulatory, and antiviral properties, it is unique in lacking influence on myeloid and erythroid progenitors. Similar dose requirement between limitin and IFN- alpha was observed for the enhancement of cytotoxic T lymphocyte activity, the augmentation of MHC class I expression, and the growth inhibition of a myelomonocytic leukaemia cell line.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5217P)
Leverancier:
ProSci Inc.
Omschrijving:
PNAS4 peptide is used for blocking the activity of PNAS4 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI2217P)
Leverancier:
ProSci Inc.
Omschrijving:
Acinus peptide is used for blocking the activity of Acinus antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI2235P)
Leverancier:
ProSci Inc.
Omschrijving:
Survivin peptide is used for blocking the activity of Survivin antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI2249P)
Leverancier:
ProSci Inc.
Omschrijving:
BACE2 peptide is used for blocking the activity of BACE2 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-282)
Leverancier:
ProSci Inc.
Omschrijving:
Activin proteins that belong to the transforming growth factor-beta (TGF- beta ) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB, also known as ActRIIB, is a type II receptor containing an extracellular domain (ECD), a transmembrane segment, and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A, activin B and inhibin A. Multiple ActRIIB isoforms can also be generated, which bind activin isoforms with different affinities.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-280)
Leverancier:
ProSci Inc.
Omschrijving:
There exists two types of tryptophanyl tRNA synthetases, the cytoplasmic form called WARS, the mitochondrial form called WARS2. WARS catalyzes the aminoacylation of tRNA (trp) with tryptophan and is induced by interferon. WARS regulates ERK, Akt, eNOS activation pathway, which are related with angiogenesis, cytoskelatal reorganization and shear stess-reponsive gene expression.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-292)
Leverancier:
ProSci Inc.
Omschrijving:
Cell surface glycoprotein CD200 Receptor 1 (CD200R1) is the receptor for the CD200 (OX-2) membrane glycoprotein. CD200R1 contains one C2- type Ig-like domain and one V-type Ig-like domain within its extracellular domain and a PTB-signaling motif in cytoplasmic domain. CD200R1 and CD200 associate via their respective N-terminal Ig-like domains. CD200R1 is restricted primarily to mast cells, basophils, macrophages, and dendritic cells. It propagates inhibitory signals despite its lacking a cytoplasmic ITIM (immunoreceptor tyrosinebased inhibitory motif). The receptor-substrate interaction may function as a myeloid downregulatory signal.
UOM:
1 * 50 µG
Itemnummer:
(PRSI2329P)
Leverancier:
ProSci Inc.
Omschrijving:
IKK epsilon peptide is used for blocking the activity of IKK epsilon antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6471P)
Leverancier:
ProSci Inc.
Omschrijving:
SEC62 peptide is used for blocking the activity of SEC62 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6485P)
Leverancier:
ProSci Inc.
Omschrijving:
DPAGT1 peptide is used for blocking the activity of DPAGT1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6483P)
Leverancier:
ProSci Inc.
Omschrijving:
DDA peptide is used for blocking the activity of DDA antibody.
UOM:
1 * 50 µG
Bel voor prijs
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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