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Eiwitten en peptiden
Itemnummer:
(PRSI90-274)
Leverancier:
ProSci Inc.
Omschrijving:
Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans (IGFL1 to 4) and one in mice (mIGFL). mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in skin or after skin wounding. In human only IGFL1 expression is increased in psoriatic skin samples. mIGFL and human IGFL1 and 3 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 (formerly TMEM-149). Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNF-R family. IGFLR1 is expressed most abundantly on mouse T cells, suggesting that mIGFL and IGFL1 produced in the skin may potentially exert regulatory functions on T cell responses.
UOM:
1 * 1 EA
Itemnummer:
(PRSI90-270)
Leverancier:
ProSci Inc.
Omschrijving:
IL-1beta is produced by activated macrophages. IL-1beta stimulates thymocyte proliferation by inducing IL-2 release, B cell maturation and proliferation and fibroblast growth factor activity. IL-1beta belongs to the IL-1 family of proteins that are involved in the inflammatory response. IL-1beta in most situations requires the inflammasome complex to be cleaved and secreted.
UOM:
1 * 1 EA
Itemnummer:
(PRSI90-267)
Leverancier:
ProSci Inc.
Omschrijving:
Periostin was originally isolated as an osteoblast-specific factor that functions as a cell adhesion molecule for pre-osteoblasts and is thought to be involved in osteoblast recruitment, attachment and spreading. Additionally, periostin expression has previously been shown to be significantly increased by both transforming growth factor beta1 (TGF-beta1) and bone morphogenetic protein 2 (BMP-2). Abnormal expression of Periostin is also linked to angiogenesis and metastasis in epithelial tumours.
UOM:
1 * 1 EA
Itemnummer:
(PRSI90-276)
Leverancier:
ProSci Inc.
Omschrijving:
RANK (TRANCE-R; CD265) is the receptor for RANKL/TRANCE/OPGL. It is essential for RANKL-mediated osteoclastogenesis and is involved in the regulation of interactions between T cells and dendritic cells.
UOM:
1 * 50 µG
Itemnummer:
(PRSI96-056)
Leverancier:
ProSci Inc.
Omschrijving:
Bcl-2-like protein 1 (BCL2L1), is also known as Apoptosis regulator Bcl-X (Bcl-XL). BCL2L1 / Bcl-XL is a homodimer protein and belongs to the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a potent inhibitor of cell death. BCL2L1 Inhibits activation of caspases. BCL2L1 appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. BCL2L1 / Bcl-XL also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.
UOM:
1 * 1 EA
Itemnummer:
(PRSI96-045)
Leverancier:
ProSci Inc.
Omschrijving:
Human recombinant CD803 (from HEK293 cells)
UOM:
1 * 1 EA
Itemnummer:
(PRSI96-049)
Leverancier:
ProSci Inc.
Omschrijving:
V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1 / B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.
UOM:
1 * 1 EA
Itemnummer:
(PRSI5559P)
Leverancier:
ProSci Inc.
Omschrijving:
TSPAN9 peptide is used for blocking the activity of TSPAN9 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5309P)
Leverancier:
ProSci Inc.
Omschrijving:
PGCC1 peptide is used for blocking the activity of PGCC1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5307P)
Leverancier:
ProSci Inc.
Omschrijving:
FAM120A peptide is used for blocking the activity of FAM120A antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5291P)
Leverancier:
ProSci Inc.
Omschrijving:
NOTUM peptide is used for blocking the activity of NOTUM antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6817P)
Leverancier:
ProSci Inc.
Omschrijving:
WDR18 peptide is used for blocking the activity of WDR18 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI96-551)
Leverancier:
ProSci Inc.
Omschrijving:
Natural cytotoxicity triggering receptor 3 (NCR3) is also known as Activating natural killer receptor p30, Natural killer cell p30-related protein (NK-p30), CD antigen CD337, 1C7, LY117. NCR3 /CD337 /NKp30 belongs to the natural cytotoxicity receptor (NCR) family. NCR3 /NKp30 contains one Ig-like (immunoglobulin-like) domain. NCR3 /NKp30 is selectively expressed by all resting and activated NK cells and weakly expressed in spleen. NCR3 is homodimer in the unliganted form. NCR3 interacts with CD3Z. NCR3 interacts with and is activated by binding to NCR3LG1 or BAG6. Engagement of NCR3 by BAG6 also promotes dendritic cell (DC) maturation, both through killing those DCs that did not properly acquire a mature phenotype, and inducing NK cells to release TNFA and IFNG, which promotes DC maturation.
UOM:
1 * 1 EA
Itemnummer:
(PRSI91-958)
Leverancier:
ProSci Inc.
Omschrijving:
Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. IL-4 is produced by mast cells, T cells, and bone marrow stromal cells. IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergic response.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-170)
Leverancier:
ProSci Inc.
Omschrijving:
Uteroglobin-Related Protein 1 (UGRP1) belongs to the secretoglobin family which has been suggested to play a role in lung inflammation and allergic diseases. UGRP1 is a 17 kDa secreted homodimeric protein that shows amino acid sequence similarity with uteroglobin. UGRP1 is expressed predominantly in the lung and low levels of expression are detected in the thyroid. Expression of UGRP1 in lung epithelial cells is enhanced by IL-10 and decreased through the activities of IL-9 and IL-5. UGRP1 interacts with the macrophage scavenger receptor with collagenous structure which is expressed by alveolar macrophages in the lung. It have suggested that UGRP1 may be involved in inflammation and pathogen clearance in the lung by binding to its receptor.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6107P)
Leverancier:
ProSci Inc.
Omschrijving:
KLOTHO peptide is used for blocking the activity of KLOTHO antibody.
UOM:
1 * 50 µG
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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