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Eiwitten en peptiden
Itemnummer:
(PRSI91-232)
Leverancier:
ProSci Inc.
Omschrijving:
Phosphopantothenoylcysteine Decarboxylase (PPC-DC) is an essential enzyme in the biosynthesis ofCoenzyme A and catalyzes the decarboxylation of PPC to Phosphopantetheine. PPC-DC catalyzes the decarboxylation of the Cysteine moiety of 4-Phosphopantothenoylcysteine (PPC) to form 4-Phosphopantetheine (PPantSH), this reaction forms part of the biosynthesis of Coenzyme A. The enzyme is a member of the larger family of Cysteine Decarboxylases including the Lantibiotic-Biosynthesizing enzymes EpiD and MrsD, all of which use a tightly bound Flavin cofactor to oxidize the Thiol moiety of the substrate to a Thioaldehyde.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-676)
Leverancier:
ProSci Inc.
Omschrijving:
E-Cadherin is a classical member of the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells, and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. Also, E-Cadherin has a potent invasive suppressor role and it is a ligand for integrin alpha-E/beta-7.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-677)
Leverancier:
ProSci Inc.
Omschrijving:
Granzyme D is a member of the granzyme family of the serine proteases which plays a role in the induction of apoptosis. T cells, lymphohematopoietic stromal cells, and granulated metrial gland cells express granzyme D, but the function of granzyme D is unknown. Previous studies reported that granzyme D is developmentally regulated during pregnancy together with granzymes E, F, and G in granulated metrial gland cells and is upregulated by IL-2 and IL-15. Granzyme D was also suggested to have a role in stromal cell-lymphocyte interactions.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-315)
Leverancier:
ProSci Inc.
Omschrijving:
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-319)
Leverancier:
ProSci Inc.
Omschrijving:
PIGR binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-129)
Leverancier:
ProSci Inc.
Omschrijving:
FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes’ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol.
UOM:
1 * 1 EA
Itemnummer:
(PRSI90-131)
Leverancier:
ProSci Inc.
Omschrijving:
FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralisation. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC).
UOM:
1 * 1 EA
Itemnummer:
(PRSI91-048)
Leverancier:
ProSci Inc.
Omschrijving:
Human Chemokine (C-C Motif) Ligand 3 (CCL3) is a small cytokine belonging to the CC chemokine family. CCL3 is primarily expressed in T cells, B cells, and monocytes after antigen or mitogen stimulation. CCL3 exhibits chemoattractive and adhesive effects on lymphocytes. CCL3 exerts multiple effects on hematopoietic precursor cells and inhibits the proliferation of hematopoietic stem cells in vitro as well as in vivo. CCR1 and CCR5 have been identified as functional receptors for CCL3.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4683P)
Leverancier:
ProSci Inc.
Omschrijving:
Nanos1 peptide is used for blocking the activity of Nanos1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3221P)
Leverancier:
ProSci Inc.
Omschrijving:
SARS Spike peptide is used for blocking the activity of the SARS Spke antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3195P)
Leverancier:
ProSci Inc.
Omschrijving:
Caspase-12 peptide is used for blocking the activity of the Caspase-12 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-067)
Leverancier:
ProSci Inc.
Omschrijving:
Tumor Necrosis Factor (TNF) is a member of the Tumor Necrosis Factor family. TNF exists as a homotrimer and interacts with SPPL2B. TNF is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. TNF is a key cytokine in the development of several inflammatory disorders. It contributes to the development of type 2 diabetes throught its effects on insulin resistance and fatty acid metabolism.
UOM:
1 * 50 µG
Itemnummer:
(PRSI96-755)
Leverancier:
ProSci Inc.
Omschrijving:
Human recombinant transferrin (from HEK293 cells)
UOM:
1 * 200 µG
Itemnummer:
(PRSI96-766)
Leverancier:
ProSci Inc.
Omschrijving:
Vascular cell adhesion protein 1 (VCAM1) is also known as CD106, INCAM-100 and L1CAM, is a cell surface sialoglycoprotein belonging to the immunoglobulin superfamily. VCAM1 / CD106 contains 7 Ig-like C2-type (immunoglobulin-like) domains. CD106 / VCAM-1 is expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue. L1CAM / VCAM-1 is Important in cell-cell recognition and appears to function in leukocyte-endothelial cell adhesion. CD106 / VCAM1 interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1 / VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. INCAM-100 / VCAM1 binds to ECMV-D capsid proteins and acts as a receptor for this virus.
UOM:
1 * 1 EA
Itemnummer:
(PRSI96-713)
Leverancier:
ProSci Inc.
Omschrijving:
Human recombinant TFPI (from HEK293 cells)
UOM:
1 * 50 µG
Itemnummer:
(PRSI5279P)
Leverancier:
ProSci Inc.
Omschrijving:
GALNT10 peptide is used for blocking the activity of GALNT10 antibody.
UOM:
1 * 50 µG
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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