Single-use+Temperature+Sensor
Numéro de catalogue:
(BOSSBS-6634R-A488)
Fournisseur:
Bioss
Description:
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM:
1 * 100 µl
Numéro de catalogue:
(BOSSBS-6634R-CY7)
Fournisseur:
Bioss
Description:
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM:
1 * 100 µl
Numéro de catalogue:
(TEST0563.4410)
Fournisseur:
TESTO
Description:
Delta P air flow ComboKit 2 equipped with clearly structured measurement menu for volume flow and parallel determination of air velocity, differential pressure, humidity and temperature in ventilation ducts or at ventilation outlets.
UOM:
1 * 1 ST
Numéro de catalogue:
(SENA0096647495163)
Fournisseur:
SenseAnywhere
Description:
This smart probe featuring a digital SenseAnywhere Bus interface has been especially designed for measuring extreme temperatures in liquid substances. Thanks to its hermetic seal made of PFA, better known as Teflon®, the Hermetically Sealed Pt100 Probe has a high level of chemical resistance. The probe is thanks to its PFA insulation waterproof and easy to clean. It can withstand aggressive substances, allowing it to take measurements in virtually all liquid fluids while being constantly submerged. The PT100 element has a Class A accuracy; measurements are provided at a very high accuracy level.
UOM:
1 * 1 ST
Numéro de catalogue:
(662-1169)
Fournisseur:
VWR Collection
Description:
Le bras à électrodes se déplace facilement dans presque tous les sens, maintenant jusqu'à 4 électrodes + 1 capteur de température en toute sécurité dans les positions sélectionnées. Commande au doigt du réglage en hauteur et de la rotation sur le support. Le bras s'articule en trois points tout en maintenant les électrodes en position verticale.
UOM:
1 * 1 ST
Fournisseur:
VWR Collection
Description:
These jumbo size display thermometers are suitable for monitoring freezers, water baths, heating blocks, incubators and refrigerators. A bottle insulates the sensor from transient temperature changes when the refrigerator door is opened. Solution is GRAS (Generally Recognised As Safe) by the FDA (Food and Drug Administration).
Fournisseur:
TESTO
Description:
These temperature probes are suitable for measurements in either semi-solid or liquid media in the food sector.
Numéro de catalogue:
(BOSSBS-6634R-A680)
Fournisseur:
Bioss
Description:
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. <i>in vitro</i>, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
UOM:
1 * 100 µl
Fournisseur:
TESTO
Description:
The testo 805 mini infrared thermometer is perfect for quick surface temperature checks, e.g. for food controls in supermarkets, for recording the temperature of incoming goods, or for scanning entire refrigerated sections.
Fournisseur:
Thermo Scientific
Description:
Tiroir coulissant simple, acier inoxydable (nécessite une installation en usine), pour gammes TSG et TSX 2305/5005
Numéro de catalogue:
(JULA8980142)
Fournisseur:
JULABO GmbH
Description:
Y-adapter cable for connecting 1 dual PT100 sensor to 2 Lemosa sockets for LC temperature laboratory controller
UOM:
1 * 1 ST
Fournisseur:
TESTO
Description:
These infrared thermometers are designed for temperature measurements in trade and industry.
Fournisseur:
TESTO
Description:
Probe for infrared thermometer, −60...+400 °C, Ø×L: 4×125 mm
Fournisseur:
Binder
Description:
Door lock, lockable door handle (single-door), Pour: M 56, M 115, M 260 Avantgarde.Line
Numéro de catalogue:
(SENA0096647495040)
Fournisseur:
SenseAnywhere
Description:
The Temp+RH Module from SenseAnywhere is a small connector with enormous potential. The module measures between 0-99%RH (non-condensing) and can monitor temperatures from −40 to +70 °C. The powerful Temp+RH Module has a swift response time because sensors are exposed to the environment directly and have minimal material around them.
UOM:
1 * 1 ST
Numéro de catalogue:
(BOSSBS-9491R-A488)
Fournisseur:
Bioss
Description:
The SOSS (Sensor of single-strand DNA) complex consists of multiple proteins that promote DNA repair and G2/M checkpoint downstream of the MRN (Mre11, Rad50 and Nbs1) complex. The complex is composed of SSBP1, INTS3 and C9orf80. Specifically, the SOSS complex binds to ssDNA at DNA lesions that influences diverse endpoints in the cellular DNA damage response. The complex is required for efficient homologous recombination-dependent repair of double-stranded breaks and ATM-dependent signaling pathways. C9orf80, also known as SOSS complex subunit C and Single-stranded DNA-binding protein-interacting protein 1 (SSBIP1), is a 104 amino acid nuclear protein that is a component of the SOSS complex. Upon DNA damage, C9orf80 along with other components of the SOSS complex migrate to the nucleus. There are two isoforms of C9orf80 that are produced as a result of alternative splicing events.
UOM:
1 * 100 µl
Appel de prix
Le stock de cet article est limité mais peut être disponible dans un entrepôt proche de vous. Merci de vous assurer que vous êtes connecté sur le site afin que le stock disponible soit affiché. Si l' est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
Le stock de cet article est limité mais peut être disponible dans un entrepôt proche de vous. Merci de vous assurer que vous êtes connecté sur le site afin que le stock disponible soit affiché. Si l' est toujours affiché et vous avez besoin d'aide, s'il vous plaît appelez-nous au 016 385 011
Ces articles ne peuvent être ajoutés au Panier. Veuillez contacter votre service client ou envoyer un e-mail à vwr.be@vwr.com
Une documentation supplémentaire peut être nécessaire pour l'achat de cet article. Un représentant de VWR vous contactera si nécessaire.
Ce produit a été bloqué par votre organisation. Contacter votre service d'achat pour plus d'informations.
Le produit original n'est plus disponible. Le remplacement représenté est disponible
Les produits marqués de ce symbole ne seront bientôt plus disponibles - vente jusqu'à épuisement de stock. Des alternatives peuvent être disponibles en recherchant le code article VWR indiqué ci-dessus. Si vous avez besoin d'une assistance supplémentaire, veuillez contacter notre Service Clientèle au 016 385 011.
|
|||||||||