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block+heaters+
Fournisseur:
Corning
Description:
Un agent antibiotique, la gentamicine, inhibe la synthèse des protéines en liant la sous-unité ribosomale 30S, en bloquant de la translocation du peptidyl-ARNt depuis le site accepteur vers le site donneur. Via un autre mode d'action, la gentamicine agit sur Pseudomonas aeruginosa en se liant à la membrane extérieure de cette bactérie. Ce faisant, il déplace les cations naturels, déstabilise la membrane et forme des trous dans la surface cellulaire. La gentamicine agit contre les bactéries à Gram négatif, les Staphylococcus aureus et d'autres bactéries à Gram positif.
Numéro de catalogue:
(PRSI76-189)
Fournisseur:
ProSci Inc.
Description:
The RM2-5 monoclonal antibody specifically binds to mouse CD2, a member of the Ig superfamily and type I transmembrane glycoprotein. CD2 is expressed on B cells, T cells, NK cells, and thymocytes and its ligand is CD48. It may be involved in immunoregulation, thymocyte maturation, and T-cell activation. The RM2-5 antibody has been reported to block CD2 mediated cell to cell adhesion.
UOM:
1 * 0,025 mg
New Product
Fournisseur:
Corning
Description:
Plusieurs formats pour une adaptation spécifique et précise aux plaques et aux blocs 96 et 384 puits.
Numéro de catalogue:
(PRSI76-965)
Fournisseur:
ProSci Inc.
Description:
The HTA125 monoclonal antibody specifically reacts with human CD284, a 110 kDa type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4). CD284 is an important molecule in the innate immunity response to bacterial lipoproteins. It is expressed by monocytes, macrophages, and endothelial cells. The HTA125 antibody can block Lipopolysaccharide-induced cytokine production and immunoprecipitate human TLR4.
UOM:
1 * 25 Tests
New Product
Numéro de catalogue:
(PRSI76-964)
Fournisseur:
ProSci Inc.
Description:
The HTA125 monoclonal antibody specifically reacts with human CD284, a 110 kDa type I transmembrane signaling molecule known as the Toll-like Receptor 4 (TLR4). CD284 is an important molecule in the innate immunity response to bacterial lipoproteins. It is expressed by monocytes, macrophages, and endothelial cells. The HTA125 antibody can block Lipopolysaccharide-induced cytokine production and immunoprecipitate human TLR4.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(PRSI76-174)
Fournisseur:
ProSci Inc.
Description:
The 23C6 monoclonal antibody specifically reacts with the human CD51/61 molecule, known as the integrin alpha v Beta 3 complex or vitronectin receptor. The complex binds to other ligands such as CD29, fibrinogen, fibrinectin, vWf, laminin, and thrombospondin. It is expressed by endothelial cells, osteoclasts, melanoma cells, and at low levels on platelets and macrophages. The 23C6 antibody is reported to be able to block the receptors ability to form interactions with some of its ligands.
UOM:
1 * 0,05 mg
New Product
Numéro de catalogue:
(PRSI76-224)
Fournisseur:
ProSci Inc.
Description:
The 17A2 monoclonal antibody specifically reacts with the mouse T lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation. CD3 is expressed by thymocytes and mature lymphocytes, and contains gamma, delta, and epsilon subunits, involved in the assembly, trafficking, and surface expression of T-cell receptor complex. The interaction between the T lymphocytes and the 17A2 antibody can be blocked by the anti-CD3e antibody, demonstrating that the 17A2 antibody recognizes the CD3 epsilon chain.
UOM:
1 * 0,5 mg
New Product
Numéro de catalogue:
(PRSI76-232)
Fournisseur:
ProSci Inc.
Description:
The 17A2 monoclonal antibody specifically reacts with the mouse T lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation. CD3 is expressed by thymocytes and mature lymphocytes, and contains gamma, delta, and epsilon subunits, involved in the assembly, trafficking, and surface expression of T-cell receptor complex. The interaction between the T lymphocytes and the 17A2 antibody can be blocked by the anti-CD3e antibody, demonstrating that the 17A2 antibody recognizes the CD3 epsilon chain.
UOM:
1 * 0,025 mg
New Product
Numéro de catalogue:
(PRSI76-230)
Fournisseur:
ProSci Inc.
Description:
The 17A2 monoclonal antibody specifically reacts with the mouse T lymphocytes receptor (TCR) associated CD3 complex, resulting in cellular activation and proliferation. CD3 is expressed by thymocytes and mature lymphocytes, and contains gamma, delta, and epsilon subunits, involved in the assembly, trafficking, and surface expression of T-cell receptor complex. The interaction between the T lymphocytes and the 17A2 antibody can be blocked by the anti-CD3e antibody, demonstrating that the 17A2 antibody recognizes the CD3 epsilon chain.
UOM:
1 * 0,025 mg
New Product
Numéro de catalogue:
(PRSI76-319)
Fournisseur:
ProSci Inc.
Description:
The OKT4 monoclonal antibody specifically binds to the CD4 receptor for the human immunodeficiency virus (HIV). CD4 is a 59 kDa single-chain transmembrane glycoprotein that expressed on the surface of most of the thymocytes, T-helper cells, and in low levels on monocytes and macrophages. CD4 is a co-receptor in the antigen-induced T cell activation (together with the MHC class II). The OKT4 and the RPA-T4 monoclonal antibodies recognize different epitopes of CD4 and they do not exhibit cross-block binding.
UOM:
1 * 0,1 mg
New Product
Numéro de catalogue:
(PRSI76-020)
Fournisseur:
ProSci Inc.
Description:
The 5C3 monoclonal antibody specifically reacts with human CD40, a 48 kDa type I glycoprotein. CD40 is part of the TNFR family and expressed on a subset of T cells, B cells, dendritic cells, and macrophages. It has been shown to be involved in the protection of B cells from apoptosis, B cell differentiation, co-stimulation, and isotype class-switching. The 5C3 antibody partially blocks the binding of CD40L (CD154). In the presence of IL-4 or PMA, the 5C3 antibody promotes B cell proliferation.
UOM:
1 * 0,5 mg
New Product
Numéro de catalogue:
(PRSI56-196)
Fournisseur:
ProSci Inc.
Description:
The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
UOM:
1 * 400 µl
New Product
Fournisseur:
HAEP LABOR CONSULT
Description:
Thermomixers pour un ou deux blocs, adaptés aux microtubes à essai, aux tubes à centrifuger, aux cuves, aux plaques PCR, aux plaques de microtitrage et aux plaques Deep Well. Une répartition homogène de la température sur l'ensemble du bloc garantit la précision et la reproductibilité sur toute la gamme de températures. Fonction de démarrage automatique, le sens du mouvement peut être modifié via le logiciel, fonction de minuterie : de 1 min à 99,99 h ou fonctionnement continu et documentation via interface USB. Le mouvement brusque des chocs du thermomixer MHL 23 donne lieu à un transfert d'énergie mécanique à l'échantillon, ce qui est particulièrement utile pour les petites quantités.
Numéro de catalogue:
(PRSI28-285)
Fournisseur:
ProSci Inc.
Description:
The protein encoded by CHRNA7 displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI76-795)
Fournisseur:
ProSci Inc.
Description:
The HMb1-1 monoclonal antibody specifically reacts with mouse/rat CD29, a 130 kDa molecule also known as integrin beta 1, GPIIa, and the VLA-beta chain. It is expressed broadly on endothelial cells, epithelial, leukocytes, and smooth muscle. CD29 forms the VLA 1-6 complexes through the non-covalent interaction with the alpha integrins of CD49 a-f. The HMb1-1 antibody is capable of inhibiting T cell proliferation and blocking cell adhesion.
UOM:
1 * 0,5 mg
New Product
Numéro de catalogue:
(PRSI3515)
Fournisseur:
ProSci Inc.
Description:
PTEN Antibody: PTEN (phosphatase and tensin homologue deleted on chromosome ten) is a dual-specificity phosphatase (with both protein and lipid phosphatase activity) first identified as a tumor suppressor gene. PTEN indirectly activates the AKT/PI3K pathway, an important signaling pathway for cell growth and proliferation by keeping levels of the second messenger PIP3 low, thereby preventing phosphoinositide-dependent kinase-1 (PDK-1) from phosphorylating and activating AKT. Expression of wild-type PTEN causes growth arrest in many cancer cell lines, but expression of a PTEN protein containing a mutation that blocks its lipid phosphatase activity failed to suppress growth of glioma cell lines suggesting that the tumor suppressive effect of PTEN is mediated solely by its lipid phosphatase activity. Other activities include the inhibition of insulin stimulated MAPK activation by blocking the insulin-receptor substrate (IRS)-1 phosphorylation and assembly of the IRS-1/Grb2/Sos complex.
UOM:
1 * 1 EA
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