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Protéines et Peptides
Numéro de catalogue:
(PRSI96-323)
Fournisseur:
ProSci Inc.
Description:
Folate Receptor 1 (FOLR1) is also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-616)
Fournisseur:
ProSci Inc.
Description:
Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI5553P)
Fournisseur:
ProSci Inc.
Description:
PICALM peptide is used for blocking the activity of PICALM antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4647P)
Fournisseur:
ProSci Inc.
Description:
Nanos2 peptide is used for blocking the activity of Nanos2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6101P)
Fournisseur:
ProSci Inc.
Description:
ZIP12 peptide is used for blocking the activity of ZIP12 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6111P)
Fournisseur:
ProSci Inc.
Description:
CXXC5 peptide is used for blocking the activity of CXXC5 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2213P)
Fournisseur:
ProSci Inc.
Description:
IRAK2 peptide is used for blocking the activity of IRAK2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-775)
Fournisseur:
ProSci Inc.
Description:
Neuroligin 4, X-Linked (NLGN4X) is a single-pass type I membrane protein that belongs to the type-B carboxylesterase/lipase family. NLGN4X is detected at higher levels in heart and at lower levels in the liver, skeletal muscle, and pancreas. NLGN4X is a putative neuronal cell surface protein involved in cell-cell-interactions. NLGN4X may act as splice site-specific ligands for beta -neurexins. It has been shown that NLGN4X is involved in the formation and remodeling of central nervous system synapses. NLGN4X also interacts with discs, large (Drosophila) homolog 4 (DLG4). Defects in NLGN4X have been associated with autism and Asperger syndrome.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-344)
Fournisseur:
ProSci Inc.
Description:
tumour necrosis factor receptor superfamily member 1B is a 461 amino acids protein that belongs to the TNFR (tumour necrosis factor receptor) superfamily Characterised by cysteine-rich extracellular domains. It contains 4 TNFR-Cys repeats. TNFRII is expressed in fetal brain. TNFRII is strongly expressed at the cartilage-pannus junction, and plays a major role in a subset of families with multiple cases of rheumatoid arthritis (RA). This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-347)
Fournisseur:
ProSci Inc.
Description:
TIP60 is the catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex is required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. TIP60 directly acetylates and activates ataxia-telangiectasia mutated (ATM). In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.
UOM:
1 * 2 µG
Numéro de catalogue:
(PRSI90-350)
Fournisseur:
ProSci Inc.
Description:
Poly(ADP-ribose) synthesised after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG hydrolyses poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose.
UOM:
1 * 2 µG
Numéro de catalogue:
(PRSI90-340)
Fournisseur:
ProSci Inc.
Description:
PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signalling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-502)
Fournisseur:
ProSci Inc.
Description:
Interleukin-12 (IL-12), also known as Natural Killer Cell Stimulatory Factor (NKSF) or Cytotoxic Lymphocyte Maturation Factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. IL-12 is produced by macrophages and B lymphocytes and has been shown to have multiple effects on T cells and Natural Killer (NK) cells. Some of these IL-12 activities include the induction of IFN-gamma and TNF in resting and activated T and NK cells; the enhancement of cytotoxic activity of resting NK and T cells, the stimulation of resting T cell proliferation in the presence of a comitogen; and the enhancement of NK cell proliferation. Current evidence indicates that IL-12 is a key mediator of cellular immunity and induces the differentiation of Th1 cells from precursor T helper cells. Based on its activities, it has been suggested that IL-12 may have therapeutic potential as a vaccine adjuvant that promotes cellular immunity and as an antitumour and anti viral agent.
UOM:
1 * 25 µG
Numéro de catalogue:
(PRSI2515P)
Fournisseur:
ProSci Inc.
Description:
CARD9 peptide is used for blocking the activity of CARD9 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-311)
Fournisseur:
ProSci Inc.
Description:
Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signalling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilisation. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signalling as well as an agonist for Tie-2 signalling, depending on the cell context.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-314)
Fournisseur:
ProSci Inc.
Description:
Cochlin is an extracellular matrix protein expressed in the cochlea and vestibule of the inner ear. Mutations in the cochlin gene are linked to the autosomal-dominant DFNA9 syndrome, a disorder characterised by hearing loss. Cochlin is also expressed in follicular dendritic cells of the spleen and the lymph nodes. The N-terminus of cochlin contains a LCCL domain also present in Factor C, a serine protease of the horseshoe crab Limulus, involved in activating the coagulation cascade in response to LPS. A recent study showed that in response to inflammation, LPS or bacterial infection, cochlin is cleaved by the proteases aggrecanases and secreted into blood circulation. The secreted cochlin (LCCL domain) seems to have a role in local cytokine production, recruitment of immune effector cells and bacterial clearance. Cochlin is secreted as two forms p8 and p18, whereas p18 being the glycosylated form of p8.
UOM:
1 * 1 EA
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