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ENZO LIFE SCIENCES
Fournisseur:
ENZO LIFE SCIENCES
Description:
PARP5a inhibitor
Numéro de catalogue:
(ENZOADIKAMCC210E)
Fournisseur:
ENZO LIFE SCIENCES
Description:
DNA-topoisomerase II, also known as Topo II or Top 2, is a multifunctional nuclear enzyme required during DNA replication, chromosome disjunction at mitosis, and other DNA-related activities because of its ability to alter DNA supercoiling. In mammalian cells, Topo II consists of two isozymes, Topo II-alpha (170kDa) and Topo II-beta (180kDa) and expression and localization of each isoform are distinct and stage specific during the cell cycle. Topo II-beta is expressed constitutively throughout the cell cycle, whereas the expression of Topo II-alpha is cell cycle-regulated, peaking in G2 to M phase and declining to a minimal level at the end of M phase. DNA-topoisomerase II is the target of some of the most active drugs used in chemotherapy and has been shown to have a critical role in neural development.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADIEKS715)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Only commercially available kit specifically validated and sensitive enough to quantify HSP70 (HSP72) in serum and plasma samples.
UOM:
1 * 1 KIT
New Product
Numéro de catalogue:
(ENZOADIEKS725A)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The HSP70B' EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in < 4.5 hours. Absorbance is read at 450 nm. Save time, money, and precious sample with fully quantitative results and increased sensitivity compared to Western blot analysis.Only commercially available ELISA kit for ultra-sensitive HSP70B' detection in cell lysates, serum, and tissue.
UOM:
1 * 1 KIT
New Product
Numéro de catalogue:
(ENZOBMLWN1120005)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Inhibits the recruitment of the co-activators β-catenin and GRIP1
UOM:
1 * 5 mg
New Product
Numéro de catalogue:
(ENZOALX201178C100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in <i>E. coli</i>.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOALX201238C100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in <i>E. coli</i>. Full length human NMNAT3 is fused at the N-terminus to a His-tag.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOALX201285C002)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in SF21 cells. Fused to a His-tag.
UOM:
1 * 2 µG
New Product
Numéro de catalogue:
(ENZOALX201134C010)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in CHO cells.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOALX201123C500)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in <i>E. coli</i>. The extracellular domain of human TRAIL (aa 95-281) is fused at the N-terminus to a His-tag and a linker peptide.
UOM:
1 * 500 µG
New Product
Numéro de catalogue:
(ENZOADI905789100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Dopamine is the predominant catecholamine neurotransmitter in the mammalian brain, where it regulates locomotor, emotional, memory, and dietary intake functions, as well as peripheral roles such as hormone secretion and renal function. Dopamine receptors (D1-D5) are members of the seven transmembrane domain containing G-protein coupled receptor (GPCR) family A, and are the target of several anti-psychosis and anti-Parkinsonian drugs. The D2, D3, and D4 dopamine receptors are encoded by homologous intron-containing genes, and signal via coupling of Gi/Go alpha G-protein subunits to inhibit adenylyl cyclase activity, as well as modulate cellular ion channel conductance of K+ and Ca2+. This is in contrast to D1 and D5 dopamine receptors, which signal via Gs alpha subunits to activate adenylyl cyclase activity. Coactivation of D1 and D2 receptors has been shown to activate a Gq mediated pathway, stimulating phospholipase C (PLC) and mobilizing intracellular calcium stores. D1 receptors were initially characterized in the striatum and retina and are expressed throughout the brain in the olfactory tubercle, islands of Calleja, entopeduncular nucleus, neocortex, hippocampus, and amygdala. Expression of the D2 receptor is found primarily in the brain (striatum, olfactory tubercle, and nucleus accumbens) and in the anterior and intermediate lobes of the pituitary.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905759100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Glycogen Synthase Kinase 3 (GSK3) exists in two isoforms, alpha and beta (GSK3α, and GSK3β). GSK3 is an active kinase that becomes phosphorylated by PKB/akt upon growth factor stimulation. Phosphorylation of GSK3α at serine 21 or GSK3β at serine 9, respectively, leads to inhibition of kinase activity of the GSK3.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905781100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Septin 5 (Sept5/CDCrel-1) is a member of the Septin family of cytoskeletal GTPases. Septin 5 expression is primarily associated with synaptic vesicles in cells of the nervous system where it acts to inhibit exocytosis, although it has also been characterized as an inhibitor of aggregation and release of storage granules in platelets. Phosphorylation of Septin 5 at Ser17 by Cdk5-p35 has been shown to mediate the interaction of Septin 5 with the SNARE protein Syntaxin-1A, regulating neurotransmitter release. Targeted disruption of the Septin 5 gene in mice failed to produce an obvious neurological phenotype, indicating its loss may be overcome by functional redundancy of other septins. Septin 5 is one of several Parkin (an E3 ubiquitin ligase) associated substrates whose accumulation results in cellular toxicity related to the onset of autosomal recessive Parkinson Disease.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOALX522024C050)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in HEK 293 cells. The cysteine-rich region of mouse GITR (aa 20-152) is fused to the Fc portion of human IgG1.
UOM:
1 * 50 µG
New Product
Numéro de catalogue:
(ENZOALX522040C050)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in HEK 293 cells. The cysteine-rich region of human DR3 (aa 25-199) is fused to the Fc portion of human IgG1.
UOM:
1 * 50 µG
New Product
Numéro de catalogue:
(ENZOENZ52402)
Fournisseur:
ENZO LIFE SCIENCES
Description:
DNA dye
UOM:
1 * 100 mg
New Product
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