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ENZO LIFE SCIENCES
Numéro de catalogue:
(ENZOBPDABS048281)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Anti-NGAL Mouse Monoclonal Antibody [clone: 28]
UOM:
1 * 1 mg
New Product
Numéro de catalogue:
(ENZOADI905793100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Leukotrienes are metabolic products of arachidonic acid formed by the action of 5-lipoxygenase (5-LO), with the principal products being leukotrienes C4 (LTC4) and B4 (LTB4). LTB4 is a dihydroxy-leukotriene produced in a variety of cells including eosinophils, neutrophils, platelets, and vascular cells, and is a potent leukocyte chemoattractant known to regulate leukocyte activation, cytokine secretion, inflammatory gene transcription, and IgE synthesis. As such, LTB4 has been implicated in a number of disease pathologies including atherosclerosis, asthma, psoriasis, and inflammatory bowel disease. The many actions of LTB4 are associated with two identified mammalian receptors, BLT1 and BLT2. BLT1 is a high-affinity LTB4 receptor expressed on peripheral leukocytes, while BLT2 is a more ubiquitously expressed low affinity LTB4 receptor whose function is not well understood. The BLT1 receptor is transiently expressed by antigen-primed T-cells in humans, and its expression is known to play a critical role in collagen-induced arthritis in mice.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905763100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The enzymatic conversion of arginine to citrulline by nitric oxide synthase (NO Synthase) leads to the formation of nitric oxide (NO). Peroxynitrite is formed following reaction of NO with superoxide, producing a potent oxidant that reacts with a variety of biological molecules, including tyrosine residues in proteins. Tyrosine nitration can inactivate enzymes and receptors that depend on tyrosine residues for their activity. Nitration prevents phosphorylation of tyrosine residues important for signal transduction.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905776100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Cyclins are a family of proteins which function as the regulatory subunits of cyclin/cyclin-dependent kinase (Cdk) holoenzymes, mediating entry into and progression through the cell cycle. Each cyclin is expressed in a temporal fashion during the cell cycle, partnering with a specific Cdk to activate its protein kinase activity. The most well defined mitotic cyclins are: cyclin D, which partners with cdks 4 and 6 during early G1 phase; cyclin E, which activates Cdk2 in the G1 to S phase transition; cyclin A, which utilizes Cdks 1 and 2 during progression through S phase and into G2; and cyclin B, which activates Cdk1 in M-phase promotion.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905813100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The octapeptide circulatory hormone Angiotensin II is a critical regulator of cardiovascular homeostasis formed in blood, with dual function in tissues of the brain, kidney, heart, and vasculature as an autocrine/paracrine growth hormone. The actions of angiotensin II are mediated by type one (AT1) and type two (AT2) angiotensin II receptors, members of the seven-transmembrane Gprotein coupled receptor (GPCR) family. AT1 receptors couple predominantly with Gq/11 alpha subunits, and signal through phospholipases C, D, and A2, inositol phosphates, and calcium channels, as well as a variety of serine/threonine and tyrosine kinases. AT1 expression is greatest in vascular smooth muscle, liver, kidney, adrenal cortex, brain, and lung, and is primarily responsible for the physiological effects of angiotensin II, including regulation of arterial blood pressure, electrolyte and water balance, thirst, hormone secretion, and renal function. The AT2 receptor displays approximately 30% identity to the AT1 receptor, and is highly expressed during embryonic development. AT2 expression in adult tissue is limited to the adrenal medulla, brain, and reproductive tissues, but is upregulated in injured tissue following myocardial infarction, vascular injury, and wound healing. AT2 receptor signaling is not dependent on G-protein coupling or receptor phosphorylation, although coupling to Gia2 and Gia3 alpha subunits occurs in some tissues. AT2 activation can stimulate tyrosine and serine/threonine phosphatases through activation of nitric oxide and cGMP, and appears to counteract the stimulatory effects of AT1 receptor and growth factor receptor signaling.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905898100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
The subtype 1 neurotensin receptor (NTS1) is a seven-transmembrane domain containing G protein coupled receptor (GPCR) that mediates most of the known effects of neurotensin. NTS1 activates a phosphatidylinositol-calcium second messenger system in the central and peripheral nervous systems, mediating such functions as hypotension, hyperglycemia, hypothermia, antinociception, and the regulation of intestinal motility and secretion. NTS1 signaling is primarily mediated via coupling to Gq/G11 family G proteins, although coupling of NTS1 through Gs and Gi/o family proteins has been shown to modulate both adenylate and guanylate cyclase activity.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905794100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Leukotrienes are metabolic products of arachidonic acid formed by the action of 5-lipoxygenase (5-LO), with the principal products being leukotrienes C4 (LTC4) and B4 (LTB4). LTB4 is a dihydroxy-leukotriene produced in a variety of cells including eosinophils, neutrophils, platelets, and vascular cells, and is a potent leukocyte chemoattractant known to regulate leukocyte activation, cytokine secretion, inflammatory gene transcription, and IgE synthesis. As such, LTB4 has been implicated in a number of disease pathologies including atherosclerosis, asthma, psoriasis, and inflammatory bowel disease. The many actions of LTB4 are associated with two identified mammalian receptors, BLT1 and BLT2. BLT1 is a high-affinity LTB4 receptor expressed on peripheral leukocytes, while BLT2 is a more ubiquitously expressed low affinity LTB4 receptor whose function is not well understood. The BLT1 receptor is transiently expressed by antigen-primed T-cells in humans, and its expression is known to play a critical role in collagen-induced arthritis in mice.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOADI905798100)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Neuropeptide Y (NPY) and the closely related peptide YY (PYY) and pancreatic polypeptide (PP) are a family of 36-amino acid, tyrosine-rich peptides with amidated C-terminal ends that are known to regulate gastrointestinal and central nervous system functions including food intake and the inhibition of anxiety. Four functional NPY receptors (Y1/Y2/Y4/Y5) have been identified to date, with a fifth (y6) being a non-functional receptor in primates that is absent from the rat genome. Y1, Y2, and Y5 receptors preferentially bind NPY and PYY, while the Y4 receptor preferentially binds PP. All four receptors signal via coupling to Gi/o alpha subunits, inhibiting adenylyl cyclase activity, thereby decreasing intracellular cAMP levels. Y1 receptor deficient mice display a variety of physical and behavioral phenotypes including obesity, hyperinsulinemia, and increased territorial behavior.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOALX522018C010)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in HEK 293 cells. The extracellular domain of human LIGHT (aa 89-240) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG®-tag.
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOALX522002C050)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in HEK 293 cells. The extracellular domain of human Fas (CD95; APO-1) (aa 7-154) is fused to the Fc portion of human IgG1.
UOM:
1 * 50 µG
New Product
Numéro de catalogue:
(ENZOALX522076C010)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in HEK 293 cells. The extracellular domain of human CD40L (CD154) (aa 116-261) is fused at the N-terminus to the Fc portion of human IgG1 and a linker peptide (20 aa).
UOM:
1 * 1 EA
New Product
Numéro de catalogue:
(ENZOALX522117C050)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Produced in CHO cells. Human LRRC32 (aa 20-627) is fused to the Fc portion of human IgG1.
UOM:
1 * 50 µG
New Product
Numéro de catalogue:
(ENZOALX550074M050)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Selective GABAB receptor agonist.
UOM:
1 * 50 mg
New Product
Numéro de catalogue:
(ENZOENZ450170001)
Fournisseur:
ENZO LIFE SCIENCES
Description:
DNMT colorimetric drug discovery kit is a simple method to detect DNA methylation activity or inhibition.
UOM:
1 * 1 KIT
New Product
Numéro de catalogue:
(ENZOENZ30904)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Host: Mouse, Isotype: IgG1
UOM:
1 * 6 mL
New Product
Numéro de catalogue:
(ENZOBPDDIAHE1B015)
Fournisseur:
ENZO LIFE SCIENCES
Description:
Purified human IgE with kappa light chains produced <i>in vitro</i> from a monoclonal hybridoma.
UOM:
1 * 1 EA
New Product
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