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ProSci Inc.
Numéro de catalogue:
(PRSI31-392)
Fournisseur:
ProSci Inc.
Description:
Anti-S Recombinant Antibody [Clone: Sb#14]
UOM:
1 * 0,05 mg
New Product
Numéro de catalogue:
(PRSI79-958)
Fournisseur:
ProSci Inc.
Description:
Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXW-7622)
Fournisseur:
ProSci Inc.
Description:
Toll-like receptor 2; toll/interleukin 1 receptor-like 4 [Homo sapiens]. This protein is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR2 gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-κB.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSIXW-7678)
Fournisseur:
ProSci Inc.
Description:
FUNCTION: The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.
SIMILARITY: Contains 1 nuclear receptor DNA-binding domain. SUBCELLULAR LOCATION: Nuclear. DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI79-994)
Fournisseur:
ProSci Inc.
Description:
proto-oncogenic cytoplasmic tyrosine kinase of the SRC family. Highly expressed in certain fully differentiated cells such as neurons, platelets and macrophages. Phosphorylation of an activation loop tyrosine activates the enzyme; phosphorylation of a tyrosine in the C-terminus by Csk inhibits the enzyme.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-998)
Fournisseur:
ProSci Inc.
Description:
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDC2 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI80-013)
Fournisseur:
ProSci Inc.
Description:
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI79-993)
Fournisseur:
ProSci Inc.
Description:
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXW-8088)
Fournisseur:
ProSci Inc.
Description:
Anti-SNX2 Chicken Polyclonal Antibody
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI80-023)
Fournisseur:
ProSci Inc.
Description:
Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXW-8105)
Fournisseur:
ProSci Inc.
Description:
FUNCTION: Major glycoprotein of vascular endothelium. May play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
DISEASE: Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) [MIM:187300]; also known as Rendu-Osler-Weber syndrome 1 (ORW1). HHT1 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia. Although the first symptom of HHT1 in children is generally nose bleed, there is an important clinical heterogeneity.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSIXW-8120)
Fournisseur:
ProSci Inc.
Description:
FUNCTION: Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (By similarity).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI42-662)
Fournisseur:
ProSci Inc.
Description:
Anti-BIRC3 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI45-647)
Fournisseur:
ProSci Inc.
Description:
Anti-GABPB2 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI45-645)
Fournisseur:
ProSci Inc.
Description:
Anti-GAB2 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI45-644)
Fournisseur:
ProSci Inc.
Description:
Anti-IKZF1 Goat Polyclonal Antibody
UOM:
1 * 1 EA
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