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ProSci Inc.
Numéro de catalogue:
(PRSI28-239)
Fournisseur:
ProSci Inc.
Description:
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by KCNN2 is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. KCNN2 is a member of the KCNN family of potassium channel genes.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI45-986)
Fournisseur:
ProSci Inc.
Description:
Anti-NUP62 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI25-635)
Fournisseur:
ProSci Inc.
Description:
BCAS2 belongs to the SPF27 family. It is involved in mRNA splicing. The protein might play an important role in breast cancer development by increasing the estrogen receptor's function.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6493)
Fournisseur:
ProSci Inc.
Description:
NEUCRIN Antibody: Neucrin, also known as Draxin, is a repulsive guidance protein for the spinal cord and forebrain commissures. It is thought to act as an antagonist of canonical Wnt signaling by inhibiting the stabilization of cytosolic beta-catenin. Ectopically expressed neucrin inhibited growth or caused misrouting of chick spinal cord commissural axons in vivo while Neucrin-null mice showed defasciculation of spinal cord commissural axons and an absence of all forebrain commisures. Other experiments in mice have shown that olfactory bulb axonal outgrowth is inhibited by Neucrin, suggesting that Neucrin functions as an inhibitory guidance cue for olfactory bulb axons.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI31-144)
Fournisseur:
ProSci Inc.
Description:
The SERPINF1 gene may play a significant role in determining the balance of angiogenesis/ antiangiogenesis during atherogenesis. A novel role of extracellular phosphorylation is shown to completely change the nature of this gene from a neutrophic to an antiangiogenic factor.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI31-130)
Fournisseur:
ProSci Inc.
Description:
The 5-HT1F receptor is present in both human vascular and neuronal tissue. This gene is localized at 3p12.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI31-125)
Fournisseur:
ProSci Inc.
Description:
APBA1 is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. APBA1 is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI31-139)
Fournisseur:
ProSci Inc.
Description:
KRT14 is a type I keratin, which is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI43-031)
Fournisseur:
ProSci Inc.
Description:
Anti-PLEKHA5 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI43-030)
Fournisseur:
ProSci Inc.
Description:
Anti-USP6 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI92-656)
Fournisseur:
ProSci Inc.
Description:
T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in the Th1-mediated immune response. TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, and dendritic cells, but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosis of apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interaction with phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumour immunity. Stimulation of TIM3 with an agonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is also regarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as two important coinhibitory regulators of T cell responses, have been implicated with the T-cell dysfunction or exhaustion associated with chronic HBV infection including HBV-related HCC.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-468)
Fournisseur:
ProSci Inc.
Description:
Interleukin-2 (IL-2) is a 133 amino acid glycoprotein with one intramolecular disulfide bond and variable glycosylation. It is secreted by activated T cells and induces proliferation and maturation of activated T cells, natural killer cells, and lymphokine activated killer cells. IL-2 also stimulates proliferation of antibody-producing B cells, activates neutrophils, and induces mononuclear cells to secrete IFN-gamma and TNF-alpha and -beta. Moreover, studies have shown that IL-2 is required for activation-induced apoptosis, an important hemeostatic mechanism in the immune system, which is involved in the maintenance of peripheral tolerance to self-antigens.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI5981P)
Fournisseur:
ProSci Inc.
Description:
KPNA1 peptide is used for blocking the activity of KPNA1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI27-554)
Fournisseur:
ProSci Inc.
Description:
ID3 is a member of the ID family. The members of the family of helix-loop-helix (HLH) proteins lack a basic DNA-binding domain and inhibit transcription through formation of nonfunctional dimers that are incapable of binding to DNA.Members of the ID family of helix-loop-helix (HLH) proteins lack a basic DNA-binding domain and inhibit transcription through formation of nonfunctional dimers that are incapable of binding to DNA.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI27-546)
Fournisseur:
ProSci Inc.
Description:
Forkhead Box Protein E3 (FOXE3, forkhead-related protein FKHL12, forkhead-related transcription factor 8) is a forkhead/winged helix transcription factor, which is expressed in the developing lens from the start of lens placode induction and becomes restricted to the anterior proliferating cells when lens fiber differentiation begins.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6495)
Fournisseur:
ProSci Inc.
Description:
RILPL1 Antibody: While the function of the Rab interacting lysosomal protein-like 1 (RILPL1) remains unknown, the homologous protein RILP is a small GTPase that controls transport to endocytic compartments, suggesting RILPL1 may have similar functions. However, overexpression of RILP caused enlarged lysosomes that are more centrally located in the cell, while overexpression of RILPL1 had no visible effect on the location or morphology of lysosomes.
UOM:
1 * 1 EA
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