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ProSci Inc.
Numéro de catalogue:
(PRSI91-596)
Fournisseur:
ProSci Inc.
Description:
Programmed cell death protein 1(PDCD1) is a single-pass type I membrane protein and contains 1 Ig-like V-type domain. PD-1 is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN- gamma by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PDCD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. PDCD1 has been suggested to be involved in lymphocyte clonal selection and peripheral tolerance, and thus contributes to the prevention of autoimmune diseases. As a cell surface molecule, PDCD1 regulates the adaptive immune response. Engagement of PD-1 by its ligands PD-L1 or PD-L2 transduces a signal that inhibits T-cell proliferation, cytokine production, and cytolytic function.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI45-633)
Fournisseur:
ProSci Inc.
Description:
Anti-FRAT2 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI45-626)
Fournisseur:
ProSci Inc.
Description:
Anti-FOXP3 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI91-595)
Fournisseur:
ProSci Inc.
Description:
Pro-neuregulin-1,Neuregulin-1 beta 1（NRG1） is a single-pass type I membrane protein and belongs to the neuregulin family .It contains 1 EGF-like domain and 1 Ig-like C2-type (immunoglobulin-like) domain. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. The protein concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-589)
Fournisseur:
ProSci Inc.
Description:
Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessels and endothelial cell growth, increasing microvascular permeability, promoting cell migration and inhibiting apoptosis. Alternatively spliced transcript variants of VEGF-A encod either secreted or cell-associated isoforms. The lymphangiogenesis may be promoted by upregulation of VEGF121, which may in turn act in part via induction of VEGF-C. It binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI29-145)
Fournisseur:
ProSci Inc.
Description:
ZNF396 acts as a DNA-dependent transcriptional repressor.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI35-303)
Fournisseur:
ProSci Inc.
Description:
Anti-Leptospira biflexa Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))
UOM:
1 * 1 mL
Numéro de catalogue:
(PRSI35-309)
Fournisseur:
ProSci Inc.
Description:
Anti-Listeria Rabbit Polyclonal Antibody
UOM:
1 * 1 mL
Numéro de catalogue:
(PRSI29-137)
Fournisseur:
ProSci Inc.
Description:
The function of ZNF498 remains unknown. The protein bears some similarity to zinc finger proteins, which are involved in DNA binding and protein-protein interactions. Alternative splicing results in two transcript variants encoding different proteins. Additional splice variants have been identified, but their biological validity has not been determined
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI29-140)
Fournisseur:
ProSci Inc.
Description:
ZNF342 contains 6 C2H2-type zinc fingers and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3643P)
Fournisseur:
ProSci Inc.
Description:
TLR3 peptide is used for blocking the activity of TLR3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3627P)
Fournisseur:
ProSci Inc.
Description:
LAMP-2 peptide is used for blocking the activity of LAMP-2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3645P)
Fournisseur:
ProSci Inc.
Description:
TLR3 peptide is used for blocking the activity of TLR3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI28-561)
Fournisseur:
ProSci Inc.
Description:
CACNB2 is a subunit of voltage-dependent calcium (Ca2+) channels, expressed in the CNS. It appears to serve an obligatory function.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI28-845)
Fournisseur:
ProSci Inc.
Description:
ZNF124 belongs to the krueppel C2H2-type zinc-finger protein family. ZNF124 may be involved in transcriptional regulation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI28-852)
Fournisseur:
ProSci Inc.
Description:
BLZF1 is required for normal Golgi structure and for protein transport from the endoplasmic reticulum (ER) through the Golgi apparatus to the cell surface.
UOM:
1 * 1 EA
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