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ProSci Inc.
Numéro de catalogue:
(PRSIXW-RP3215)
Fournisseur:
ProSci Inc.
Description:
The covalent attachment of prenyl lipids, such as farnesyl or geranylgeranyl groups, by specific transferases is indispensable for the cellular sorting of many proteins. James et al. (1994) identified in hamster a farnesylated protein, called peroxisomal farnesylated protein or PxF, that localized to the outer surface of peroxisomes.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXW-RP3263)
Fournisseur:
ProSci Inc.
Description:
The tetramer binds two molecules of protoheme IV. It is a homotetramer involved in tryptophan catabolism. There is a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI46-882)
Fournisseur:
ProSci Inc.
Description:
Anti-OTUB2 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSIXW-RP3079)
Fournisseur:
ProSci Inc.
Description:
A carboxylic ester + H2O = an alcohol + a carboxylic anion. Homodimer. Cytoplasmic vesicles. There are two major electrophoretic isotypes. The sequence of the ESD*1 variant is shown. Similar to yeast HRE299.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-297)
Fournisseur:
ProSci Inc.
Description:
The TNF family ligand ectodysplasin A (EDA) and its receptor EDAR are required for proper development of skin appendages such as hair, teeth, and eccrine sweat glands. Loss of function mutations in the Eda gene cause X-linked hypohidrotic ectodermal dysplasia (XLHED), a condition that can be ameliorated in mice and dogs by timely administration of recombinant EDA. The Eda gene on the X chromosome is transcribed as multiple splice variants, only two of which code for the receptor-binding C-terminal TNF homology domain. These two variants code for 391- and 389-amino acid-long proteins called EDA1 and EDA2. EDA1 binds EDAR, whereas EDA2 binds to another receptor, XEDAR. The biology of EDA2 and XEDAR is distinct from that of EDA1. Indeed, XEDAR-deficient mice have no obvious ectodermal dysplasia phenotype, whereas mice deficient in EDA, EDAR, or the signalling adaptor protein EDARADD all display virtually indistinguishable ectodermal dysplasia phenotypes, indicating the predominance of the EDA1-EDAR axis in the development of skin-derived appendages.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-291)
Fournisseur:
ProSci Inc.
Description:
Notch signalling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signalling is also involved in cellular processes through-out adulthood. Signalling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-289)
Fournisseur:
ProSci Inc.
Description:
MultimericCD40L™ is a high activity construct in which two trimeric CD40 ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively simulates the natural membrane-assisted aggregation of CD40L in vivo. It provides a simple and equally potent alternative to CD40L+enhancer combinations. MultimericCD40L™ has been shown to suppress alum-induced IL-1beta release and caspase-1 activation in a dose-, CD40- and time dependent manner, without affecting BMDM (Bone marrow-derived macrophages) viability. It also effectively suppressed the inflammasome function triggered by NLRP3 activators. The secretion of caspase-1 independent inflammatory mediators has been shown to be unaltered or even enhanced.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI42-861)
Fournisseur:
ProSci Inc.
Description:
Anti-HSD11B1 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI42-859)
Fournisseur:
ProSci Inc.
Description:
Anti-FGF23 Goat Polyclonal Antibody
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI27-687)
Fournisseur:
ProSci Inc.
Description:
PAX7 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box gene 7 is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Alternative splicing in this gene has produced two known products but the biological significance of the variants is unknown.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI27-693)
Fournisseur:
ProSci Inc.
Description:
ZNFN1A1 has a role in progesterone activation of fatty acid amide hydrolase in human T lymphocytes.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-283)
Fournisseur:
ProSci Inc.
Description:
IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI2075P)
Fournisseur:
ProSci Inc.
Description:
RICK peptide is used for blocking the activity of RICK antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2093P)
Fournisseur:
ProSci Inc.
Description:
CX3CR1 peptide is used for blocking the activity of CX3CR1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-505)
Fournisseur:
ProSci Inc.
Description:
ASB5 is a member of the¡¡ankyrin repeat and SOCS box-containing (ASB) family of proteins.¡¡They contain ankyrin repeat sequence and SOCS box domain. The SOCS¡¡box serves to couple suppressor of cytokine signalling (SOCS)¡¡proteins and their binding partners with the elongin B and C¡¡complex, possibly targeting them for degradation.The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but their full length sequences are not known.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI26-500)
Fournisseur:
ProSci Inc.
Description:
The exact function of ND6 remains unknown.
UOM:
1 * 50 µG
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