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How To Profile & Characterise Different Glycan Populations

Webinar

Tuesday, 27th October, 2020
15:00 to 16:00 CEST (Berlin, Paris, Madrid)

Replay

How to profile and characterise different glycan populations

Glycosylation is an important and diverse post translational modification on proteins. On therapeutic proteins the glycan structure effects efficacy and safety and so must be characterised. The diversity of the glycan population varies between proteins and this should be taken into account when developing analytical methods.

In this webinar we will present:

  • Sample preparation options for released and labelled glycans
  • HILIC and mixed mode glycan separation column technologies and their practical implementation
  • Alternative high resolution mass spectrometry options for glycan analysis
  • Matching the glycan population complexity to the analytical method chosen

Thermo Scientific has over 20 years of innovations and publications around the separation of glycans. Join our webinar to learn how mixed mode GlycanPac and Accucore amide HILIC columns can optimise and enhance your glycan separations.

For more information, please contact us at webinar@avantorsciences.com

Presented by:

Dr. Ken Cook

Dr. Ken Cook has over 30 years’ experience supporting and developing solutions within chromatography. As a bio-separations expert, his work involves the support of biopharmaceutical applications to characterise protein and oligonucleotide-based biotherapeutics. This involves ongoing collaborations with the biopharmaceutical industry and academia. Methods for the characterisation of therapeutic proteins include peptide mapping by LC/HRMS. Developments in charged variant analysis including novel coupling to MS, glycan analysis, aggregate analysis and on-line process monitoring. Gene therapy characterisation is a growing interest which has had much success.