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Therapeutic proteins were introduced many years ago and have been constantly evolving. Since the introduction of monoclonal antibodies, we now have antibody drug conjugates, bispecific antibodies, fragments and fusion proteins of many types in development stages. The analytics for these needs to keep pace with this evolution.
In this webinar, we will present chromatography findings on:
New workflows for intact and peptide mapping characterization of proteins
New column chemistries for charge variant analysis with pH and salt gradients
New rapid desalting SEC column for high throughput analysis, ADC analysis with HIC and reversed phase chemistries
New digestion workflows coupled to a new peptide mapping column for sequence verification and post translation modification analysis
Enhance the capabilities of R&D, as well as, providing robust QC analytical methods with learnings from this webinar!
Thermo Scientific has over 20 years of innovations backed by publications around biomolecule separation and characterization.
The session will finish with a short Q&A and include a live chat with Dr. Ken Cook.
Dr. Ken Cook began his career in academia as a Biochemistry lecturer focused on protein chemistry and metabolism. Today, with well over 30 years’ industry experience working for Dionex, then Thermo Fisher Scientific, his vast knowledge supporting and developing solutions within chromatography brand him a bio-separations expert.
Currently, his work involves the support of Bio-Pharmaceutical applications to characterise protein and oligonucleotide-based bio-therapeutics. This involves ongoing collaborations with the Biopharmaceutical industry and academia. Methods for the characterisation of therapeutic proteins include peptide mapping by LC/HRMS. Developments in charged variant analysis including novel coupling to MS, Glycan analysis, Aggregate analysis and on-line process monitoring. Gene therapy characterisation is a growing interest which has had much success.
Given his immense experience, it is an honour to have Ken share his knowledge.
