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Protéines et Peptides
Numéro de catalogue:
(PRSI90-262)
Fournisseur:
ProSci Inc.
Description:
BCMA is a receptor for BAFF and APRIL. It promotes B cell survival and plays a role in the regulation of humoral immunity. It's downstream signalling is dependent on NF-kappaB and JNK.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-311)
Fournisseur:
ProSci Inc.
Description:
FcRn complex consist of two subunits: IgG receptor FcRn large subunit p51（alpha chain) and Beta-2-microglobulin（Beta chain). The complexes is similar in structure to MHC class I-like heterodimer. Beta-2-microglobulin involved in the presentation of peptide antigens to the immune system. FcRn binds to the Fc region of monomeric immunoglobulins gamma, mediates the uptake of IgG from milk,Possible role in transfer of immunoglobulin G from mother to fetus. A principal component of antibody transport is the neonatal receptor for the Fc portion of immunoglobulin, a heterodimer of a MHC-1 alpha-chain homolog ( FcRn ) and beta-2-microglobulin ( B2M ).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-440)
Fournisseur:
ProSci Inc.
Description:
Periostin is a secreted, homodimeric protein that belongs to the periostin family of the FAS1 superfamily of molecules. It is a TGF-beta inducible molecule that serves as both an adhesion molecule and tumour suppressor. It is synthesised by smooth muscle cells, fibroblasts and osteoblasts, as well as in the periosteum and periodontal ligament.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-437)
Fournisseur:
ProSci Inc.
Description:
Cytochrome b5 type B (CYB5B) is a membrane of the cytochrome b5 family. It contains 1 cytochrome b5 heme-binding domain. Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. In the mitochondrion of eukaryotes and in aerobic prokaryotes, cytochrome b is a component of respiratory chain complex III also known as the bc1 complex or ubiquinol-cytochrome c reductase.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-432)
Fournisseur:
ProSci Inc.
Description:
GDNF family receptor alpha-2 is a glycosylphosphatidylinosito l (GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 mediates the NRTN-induced autophosphorylation and activation of the RET receptor. It also able to mediate GDNF signalling through the RET tyrosine kinase receptor. It acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-435)
Fournisseur:
ProSci Inc.
Description:
Hematopoietic lineage cell-specific protein (HCLS1) is a protein that in humans is encoded by the HCLS1 gene. It is expressed only in tissues and cells of hematopoietic origin. It is substrate of the antigen receptor-coupled tyrosine kinase and plays a role in antigen receptor signalling for both clonal expansion and deletion in lymphoid cells. It may also be involved in the regulation of gene expression.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-714)
Fournisseur:
ProSci Inc.
Description:
Alpha-2-HS-glycoprotein (AHSG) is a glycoprotein that is composed of two subunits, the A and B chains, belongs to the Cystatin family of proteases inhibitors. It is highly expressed in embryonic cells and adult hepatocytes, and is expressed to a lesser extent in monocytes/macrophages. AHSG is an important circulating inhibitor of calcification in vivo, and is downregulated during the acute-phase response. It is involved in several functions, such as endocytosis, brain development and the formation of bone tissue. In addition, AHSG may influence the resolution of inflammation by modulating the phagocytosis of apoptotic cells by macrophages. ASHG blocks TGF-beta-dependent signalling in osteoblastic cells.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-482)
Fournisseur:
ProSci Inc.
Description:
Protein jagged-1 (JAG1) is also known as Jagged1, hJ1, JAGL1 and CD339, which is a single-pass type I membrane protein containing one DSL domain and 15 EGF-like domains. JAG1 is widely expressed in adult and fetal tissues,the expression of JAG1 is up-regulated in cervical squamous cell carcinoma and also expressed in bone marrow cell line HS-27a.JAG1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. JAG1 is involved in early and late stages of mammalian cardiovascular development. JAG1 inhibits myoblast differentiation by similarity and enhances fibroblast growth factor-induced angiogenesis (in vitro).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3247P)
Fournisseur:
ProSci Inc.
Description:
TRIM5 alpha peptide is used for blocking the activity of the TRIM5 alpha antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3391P)
Fournisseur:
ProSci Inc.
Description:
TAB3 peptide is used for blocking the activity of TAB3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-113)
Fournisseur:
ProSci Inc.
Description:
Lipocalin-2 is an iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-010)
Fournisseur:
ProSci Inc.
Description:
Nicotinamide phosphoribosyltransferase (Nampt; pre-B cell colony-enhancing factor; PBEF; Visfatin) is an 52kDa adipokine secreted by adipose tissue and involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). Two forms of Nampt exist, an intracellular form (iNampt) and an extracellular form (eNampt). While the function of iNampt as an essential and rate-limiting NAD+ biosynthetic enzyme is well established, the physiological role of eNampt is still a matter of debate. Nampt has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-056)
Fournisseur:
ProSci Inc.
Description:
ANGPTL7 (Angiopoietin-like protein 7) is expressed in various tissues and regulates angiogenesis. Human ANGPTL7 was characterised as a potent target gene of the WNT/beta-catenin signalling pathway, and is a pharmacogenomics target in the fields of oncology and regenerative medicine. Overexpression of ANGPTL7 increases collagen expression and might exert a pathogenic role in glaucoma.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5763P)
Fournisseur:
ProSci Inc.
Description:
RNF8 peptide is used for blocking the activity of RNF8 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-374)
Fournisseur:
ProSci Inc.
Description:
Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGF-beta superfamily. It plays a dominant role in embryonic dorsalventral patterning, organogenesis, limb bud formation and bone formation and regeneration. BMP-2 signals through heterodimeric complexes composed of a type I receptor (Activin RI, BMP-RIA or BMP-RIB) and a type II receptor (BMP-RII or Activin RIIB). BMP-2 induces chondrocyte proliferation, endochondral bone formation, longitudinal bone growth and bone and cartilage repair. It induces ectopic bone formation or calcification by promoting osteogenic and chondrogenic differentiation in mesenchymal cells, stem cells and vascular smooth muscle cells. It also promotes the maintenance and repair of colonic epithelium, suppresses neuronal dopamine synthesis and release, induces apoptosis in medulloblastoma cells and is required for cardiac contractility.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-371)
Fournisseur:
ProSci Inc.
Description:
B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting T cell proliferation, cytokine production and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production and generation of alloreactive cytotoxic T cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumour cancer cells. The role of B7-H4 in tumour progression may be to transform precancerous cells and then protect them from immunosurveillance.
UOM:
1 * 1 EA
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