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Protéines et Peptides
Numéro de catalogue:
(PRSI91-238)
Fournisseur:
ProSci Inc.
Description:
Protein S100-P (S100P) belongs to the S100 family of Calcium-Binding Proteins. S100P is 95 amino acids in length and it contains 2 EF-Hand Calcium-Binding Motifs. The EF-Hand Motif binds calcium, which likely alters molecular conformation. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells and it is involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. In addition to binding Ca, S100P also binds Zn and Mg, and may play a role in the etiology of prostate cancer.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-242)
Fournisseur:
ProSci Inc.
Description:
U6 snRNA-Associated Sm-Like Protein LSm1 (LSM1) belongs to the snRNP Sm proteins family. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which plays an important role in pre-mRNA splicing. LSM1 binds specifically to the 3-terminal U-tract of U6snRNA. LSM1 can interact with SLBP when histone mRNA is being rapidly degraded during the S phase. In addition, LSM1 is associated with cellular transformation and the progression of several malignancies including mesothelioma, lung cancer and breast cancer.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-269)
Fournisseur:
ProSci Inc.
Description:
Ubiquitin-Conjugating Enzyme E2 S (UBE2S) is a member of the Ubiquitin-Conjugating Enzyme family. UBE2S interacts with CDC20, FZR1/CDH1 and VHL. UBE2S can form a thiol ester linkage with Ubiquitin in an Ubiquitin Activating Enzyme-Dependent manner, a characteristic property of Ubiquitin Carrier Proteins. UBE2S acts as an essential factor of the Anaphase Promoting Complex/Cyclosome, a cell cycle-regulated Ubiquitin ligase that controls progression through mitosis. UBE2S is also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-140)
Fournisseur:
ProSci Inc.
Description:
Protein Phosphatase 1G (PP1MG) is a cytoplasmic protein that belongs to the PP2C family. PPM1G is widely expressed; it is abundant in testis, skeletal muscle, and heart. PPM1G is a negative regulator of cell stress response pathways. PPM1G is responsible for the dephosphorylation of Pre-mRNA splicing factors, an important factor for the formation of functional spliceosome. PPM1G also plays a role in regulating cell cycle progression.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-401)
Fournisseur:
ProSci Inc.
Description:
CD33 is a type I Lectin belonging to the Ig superfamily. CD33 contains an N terminal Ig like V type domain, which mediates sialic acid binding, followed by one Ig like C2 type domain, a transmembrane region and a cytoplasmic tail containing two conserved immunoreceptor tyrosine based inhibition motifs (ITIMs). Eleven human Siglecs have been characterized. Siglecs 5 to 11 share a high degree of sequence similarity with CD33/Siglec3 both in their extracellular and intracellular regions. They are collectively referred to as CD33 related Siglecs. CD33 related Siglecs have differential expression pattern within the hematopoietic system. They are involved in the regulation of cellular activation within the immune system. Siglec 3 expression is restricted to cells of myelomonocytic lineage. Siglec3 recruits SHP1 and SHP2 to its ITIMs upon phosphorylation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-412)
Fournisseur:
ProSci Inc.
Description:
Tissue Inhibitor of Metalloproteinases 1 (TIMP-1) complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13, and MMP-16. TIMP-1 does not act on MMP-14.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-413)
Fournisseur:
ProSci Inc.
Description:
Chorionic Somatomammotropin Hormone (CSH1) belongs to the Somatotropin/Prolactin family. It is located at the growth hormone locus on chromosome 17. It is produced by cells in the syncytiotrophoblast layer of the placenta only during pregnancy. Although CSH1 does not interact with GHR but only activates PRLR through zinc-induced dimerization. It is expressed mainly in the placenta and utilizes multiple transcription initiation sites. CSH1 plays an important role in stimulating lactation, growth control and metabolism.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-673)
Fournisseur:
ProSci Inc.
Description:
Scavenger receptor class B member 1 (SRB1) is also known as SR-BI, CD36 and LIMPII analogous 1 (CD36L1), CLA-1, is a member of the scavenger receptor family or CD36 family. CD36L1 is an integral membrane protein found in numerous cell types/tissues, including the liver and adrenal. SRB1 is receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. CLA-1 facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as high-density lipoprotein (HDL) and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. SCARB1 is, along with CD81, the receptor for the entry of the Hepatitis C virus glycoprotein E2 in liver cells, and binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. SRB1 plays an important role in the uptake of HDL cholesteryl ester.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-428)
Fournisseur:
ProSci Inc.
Description:
T cells require a signal induced by the engagement of the T cell receptor and a costimulatory signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 (PD-L2) is one of two ligands for programmed death-1 (PD-1; CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumour cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI92-600)
Fournisseur:
ProSci Inc.
Description:
Alpha-2-antiplasmin, also called Serpin F2, is a serine protease inhibitor (serpin) responsible for inactivating plasmin, and an important enzyme participates in fibrinolysis and degradation of other proteins. In liver cirrhosis, there is decreased production of alpha 2-antiplasmin, leading to decreased inactivation of plasmin and an increase in fibrinolysis. Serpin F2 is major expressed on liver and kidney. Some other tissues such as muscle, intestine, central nervous system, and placenta also express Serpin F2 mRNA at a moderate level indicated that it is a key regulator of plasmin-mediated proteolysis in these tissues.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6295P)
Fournisseur:
ProSci Inc.
Description:
ROCK1 peptide is used for blocking the activity of ROCK1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6291P)
Fournisseur:
ProSci Inc.
Description:
PRR5 peptide is used for blocking the activity of PRR5 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2025P)
Fournisseur:
ProSci Inc.
Description:
IKK alpha peptide is used for blocking the activity of IKK alpha antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2015P)
Fournisseur:
ProSci Inc.
Description:
Apaf1 peptide is used for blocking the activity of Apaf1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(344220-5)
Fournisseur:
Merck Millipore (Calbiochem)
Description:
The formyl peptide receptor-like 1 antagonist, WRW controls the biological activity of formyl peptide receptor-like 1 (FRPL1).
UOM:
1 * 5 mg
Fournisseur:
Merck Millipore (Calbiochem)
Description:
Soy bean trypsin inhibitor
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