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Protéines et Peptides
Numéro de catalogue:
(PRSI91-736)
Fournisseur:
ProSci Inc.
Description:
Dentin Matrix Acidic Phosphoprotein 1 (DMP-1) is an extracellular matrix protein and a member of the small integrin binding ligand N-linked glycoprotein family. DMP-1 is expressed in teeth particularly in odontoblast, ameloblast, and cementoblast. DMP-1 is critical for proper mineralization of bone and dentin. DMP-1 may have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, the unphosphorylated form of DMP-1 acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase, DMP-1 is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite. DMP-1 mutations have also been shown to cause rickets hypophosphatemic autosomal recessive type 1 (ARHR1).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-354)
Fournisseur:
ProSci Inc.
Description:
SLAM Family Member 6 (SLAMF6) is a 60 kD single-pass type I membrane protein that belongs to the SLAM subgroup of the CD2 family. Human SLAMF6/ NTB-A contains a 205 amino acid extracellular domain (ECD) with one Ig-like V-set and one Ig-like C2-set domain, a 21 amino acid transmembrane segment and an 84 amino acid cytoplasmic domain, with two immunoreceptor tyrosine-based switch motifs. SLAMF6 is a homodimer. SLAMF6 can interact with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. Phosphorylation-dependent NTB-A association with SAP is required for full production of IFN- gamma by NK cells and independent of EAT-2 binding. It Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. On B cells, NTB-A modulates immunoglobulin class switching and the balance between tolerance and autoimmunity.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4427P)
Fournisseur:
ProSci Inc.
Description:
ATG16 peptide is used for blocking the activity of ATG16 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4429P)
Fournisseur:
ProSci Inc.
Description:
Cathelicidin peptide is used for blocking the activity of Cathelicidin antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4463P)
Fournisseur:
ProSci Inc.
Description:
Slitrk3 peptide is used for blocking the activity of Slitrk3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6771P)
Fournisseur:
ProSci Inc.
Description:
YPEL1 peptide is used for blocking the activity of YPEL1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7361P)
Fournisseur:
ProSci Inc.
Description:
16 amino acid peptide near the amino terminus of human TLX1.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7413P)
Fournisseur:
ProSci Inc.
Description:
17 amino acids near the center of Rift Valley Fever Virus.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-515)
Fournisseur:
ProSci Inc.
Description:
Coronin 6, a newly identified member of the coronin family, is highly enriched at adult NMJs and regulates AChR clustering via modulating the interaction between receptors and the actin cytoskeletal network. Coronins are a family of conserved actin-binding proteins originally identified in the actin-rich structure of the amoeba Dictyostelium discoideum . To date, seven members of coronins have been identified in mammals, and most exhibit tissue-specific distribution patterns. Coronin 6 is prominently expressed in adult muscle and enriched at the NMJ. Studies with cultured myotubes reveal that Coronin 6 regulates both agrin- and laminin-induced AChR clustering and is important for anchoring AChRs onto the actin cytoskeleton. Also, both the C-terminal region and a conserved Arg29 residue at the N terminus of Coronin 6 are essential for its actin-binding activity and stabilisation of AChR–cytoskeleton linkage. Importantly, in vivo knockdown of Coronin 6 in mouse skeletal muscle fibers leads to destabilisation of AChR clusters, which demonstrates that Coronin 6 is a critical regulator of AChR clustering at the postsynaptic region of the NMJs through modulating the receptor-anchored actin cytoskeleton. The human Coronin 6 has five isoforms produced by alternative splicing, and tissue-specific expression of these isoforms are unclear.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-514)
Fournisseur:
ProSci Inc.
Description:
Neutrophil cytosol factor 1( NCF1) is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is characterised as a multicomponent enzyme which is activated to produce superoxide anion. NCF2, NCF1, and a membrane bound cytochrome b558 are required for the activation of the latent NADPH oxidase. The human NCF1 gene encodes a 390 amino acids protein without a signal peptide. The NCF1 gene interacts with other subunits of nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) and plays an important role in innate immunity, producing reactive oxygen species and reducing the severity and duration of parasitic infection and autoimmune disease. NCF1 also has a role in T cell activation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-518)
Fournisseur:
ProSci Inc.
Description:
Mouse beta -NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. beta -NGF is a potent neurotrophic factor that signals through its receptor beta -NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. beta -NGF also acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-636)
Fournisseur:
ProSci Inc.
Description:
Endothelial protein C receptor (PROCR) is also known as Activated protein C receptor (APC receptor), Endothelial cell protein C receptor, CD antigen CD201. PROCR / EPCR / CD201 is a N-glycosylated protein, with a soluble form exists. PROCR is probably released by a metalloprotease. PROCR seems to have the same activity as the membrane-bound form. PROCR / EPCR / CD201 is expressed strongly in the endothelial cells of arteries and veins in heart and lung. PROCR binds activated protein C and enhances protein C activation by the thrombin - thrombomodulin complex. PROCR plays a role in the protein C pathway controlling blood coagulation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-656)
Fournisseur:
ProSci Inc.
Description:
Recombinant protein L (from <i>E. coli</i>)
UOM:
1 * 2 mg
Numéro de catalogue:
(PRSI96-630)
Fournisseur:
ProSci Inc.
Description:
Human recombinant PLAU (from HEK293 cells)
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-111)
Fournisseur:
ProSci Inc.
Description:
Cluster of differentiation 14 (CD14), is a cell surface glycoprotein, and is a is a component of the innate immune system. CD14 is a myelomonocytic differentiation antigen preferentially expressed on monocytes, macrophages, and activated granulocytes. CD14 exists in two forms. Either it is anchored into the membrane by a glycosylphosphatidylinositol tail (mCD14) or it appears in a soluble form (sCD14). Soluble CD14 either appears after shedding of mCD14 (48 kDa) or is directly secreted from intracellular vesicles (56 kDa). CD14 acts as a co-receptor (along with the Toll-like receptor TLR 4 and MD-2) for the detection of bacterial lipopolysaccharide (LPS). CD14 can bind LPS only in the presence of lipopolysaccharide-binding protein (LBP). CD14 has been proposed to be involved in various biological processes, including transportation of other lipids, cell-cell interaction during different immune responses, as well as recognition of apoptotic cells. Although LPS is considered its main ligand, CD14 also recognizes other pathogen-associated molecular patterns. CD14+ cells are monocytes that can differentiate into a host of different cells. CD14 has been shown to interact with Lipopolysaccharide-binding protein.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI6757P)
Fournisseur:
ProSci Inc.
Description:
TSHZ2 peptide is used for blocking the activity of TSHZ2 antibody.
UOM:
1 * 50 µG
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