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Protéines et Peptides
Numéro de catalogue:
(PRSI91-129)
Fournisseur:
ProSci Inc.
Description:
Interleukin-20 (IL-20) is a member of the IL-10 family of regulatory cytokines that includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences but they are dissimilar in their biological functions. IL-20 exhibits approximately 28% amino acid identity with IL-10 and 76% amino acid identity with mouse IL-20. There are two heterodimeric receptor complexes for IL-20. The first is composed of IL-20 R alpha and IL-20 R beta . The second is composed of IL-22 R and IL-20 R beta . Whereas the IL-22 R/IL-20 R beta complex is shared with IL-24, the IL-20 R alpha/IL-20 R beta complex is shared with both IL-19 and IL-24. IL-20 has been shown to initiate transduction cascades involving STAT3 and stimulates the induction of pro-inflammatory genes including TNF- alpha and MCP-1. Initial functional studies using transgenic mice suggest that IL-20 has the ability to regulate skin development. The over-expression of both human and mouse forms of IL-20 results in keratinocyte hyper-proliferation, abnormal epidermal differentiation, and neonatal lethality. In humans, IL-20 and its receptors are up-regulated in psoriatic skin, and polymorphisms in the IL-20 gene have been associated with plaque-type psoriasis. IL-20 may also have a role in hematopoiesis. It enhances the proliferation of multi-potential progenitors in vitro and increases their numbers and cell cycling status in IL-20 transgenic mice. IL-20 is also shown to suppress COX-2 and PGE2 and acts as an inhibitor of angiogenesis in model systems.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4017P)
Fournisseur:
ProSci Inc.
Description:
BANF1 peptide is used for blocking the activity of BANF1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-119)
Fournisseur:
ProSci Inc.
Description:
Fatty Acid-Binding Protein 4 (FABP4) is a cytoplasm protein that belongs to the fatty-acid binding protein (FABP) family of calycin superfamily. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids. FABP4 is expressed in a differentiation-dependent fashion in adipocytes and is a critical gene in the regulation of the biological function of these cells. FABP4 is thought to participate in Lipid transport protein in adipocytes. FABP4 binds to the long chain fatty acids and retinoic acid, delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. FABP4 modulates inflammatory responses and cholesterol ester accumulation. FABP4 is a plasma marker of metabolic disturbances in HIV-infected patients, and therefore, could serve to guide therapeutic intervention in this group of patients.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-254)
Fournisseur:
ProSci Inc.
Description:
Haloacid Dehalogenase-Like Hydrolase Domain-Containing Protein 22 (HDHD2) is a member of the HAD-like hydrolase superfamily. HDHD2 includes L-2-Haloacid Dehalogenase, Epoxide Hydrolases and Phosphatases. There are two active sites in HDHD2 - an L-2-Haloacid Dehalogenase and a Carboxylate group. The L-2-Haloacid Dehalogenase active site catalyzes the hydrolytic dehalogenation of D- and L-2-Haloalkanoic Acids, producing L- and D-2-Hydroxyalkanoic Acids.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6403P)
Fournisseur:
ProSci Inc.
Description:
SPRYD2 peptide is used for blocking the activity of SPRYD2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6385P)
Fournisseur:
ProSci Inc.
Description:
GEMC1 peptide is used for blocking the activity of GEMC1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6399P)
Fournisseur:
ProSci Inc.
Description:
CCDC141 peptide is used for blocking the activity of CCDC141 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-026)
Fournisseur:
ProSci Inc.
Description:
Interleukin-8 (IL-8) belongs to the neutrophil-specific CXC family of chemokines. It is one of the initial cytokines released from a variety of cell types, including T cells, endothelial cells and fibroblasts, in response to an inflammatory stimulus and acts by recruiting neutrophils, T-cells and basophils to the site of inflammation. Elevated Interleukin-8 levels are associated with the onset of a variety of disease states.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-031)
Fournisseur:
ProSci Inc.
Description:
Mouse Interleukin-1 (IL-1) designates two proteins, IL-1 alpha and IL-1 beta , which are the products of distinct genes, but recognize the same cell surface receptors. IL-1 alpha and IL-1 beta are structurally related polypeptides that show approximately 25% homology at the amino acid level. Both proteins are produced by a wide variety of cells in response to stimuli such as those produced by inflammatory agents, infections, or microbial endotoxins. The proteins are synthesized as 31 kDa precursors that are subsequently cleaved into proteins with molecular weights of approximately 17.5 kDa.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-021)
Fournisseur:
ProSci Inc.
Description:
Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Today, IL-17 represents a family of structurally related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI40-564)
Fournisseur:
ProSci Inc.
Description:
The MCP proteins belong to the CC chemokine family, and signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross reacts across species. Recombinant human MCP-1 is an 8.6 kDa protein containing 76 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.
UOM:
1 * 20 µG
Numéro de catalogue:
(PRSI4055P)
Fournisseur:
ProSci Inc.
Description:
VISA peptide is used for blocking the activity of VISA antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7357P)
Fournisseur:
ProSci Inc.
Description:
19 amino acid peptide near the amino terminus of human RNF20.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4733P)
Fournisseur:
ProSci Inc.
Description:
DNAL1 peptide is used for blocking the activity of DNAL antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4731P)
Fournisseur:
ProSci Inc.
Description:
MED28 peptide is used for blocking the activity of MED28 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5843P)
Fournisseur:
ProSci Inc.
Description:
SCUBE1 peptide is used for blocking the activity of SCUBE1 antibody.
UOM:
1 * 50 µG
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