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Protéines et Peptides
Numéro de catalogue:
(PRSI91-255)
Fournisseur:
ProSci Inc.
Description:
alpha-Soluble NSF Attachment Protein (SNAP- alpha) is a member of the SNAP (Soluble NSF Attachment Protein) family. SNAP- alpha interacts with PRKCABP and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2. SNAP- alpha is required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. SNAP- alpha is in charge of the binding of NSF and therefore the formation of a 20S fusion particle.
UOM:
1 * 50 µG
Fournisseur:
Shenandoah Biotechnology
Description:
Receptor activator of nuclear factor kappa-B Ligand (RANK Ligand) is a cell-bound marker related to the tumor necrosis factor (TNF) family of proteins. RANK Ligand plays a critical role in bone metabolism and osteoclast differentiation. T cell expression of RANK Ligand promotes dendritic cell maturation.
Fournisseur:
Shenandoah Biotechnology
Description:
Visfatin is an adipokine produced by visceral adipose tissue. Visfatin acts as a pro-inflammatory factor for peripheral blood mononuclear cells (PBMCs) and mimics the effects of insulin on adipocytes, monocytes, and hepatocytes.
Fournisseur:
Shenandoah Biotechnology
Description:
Macrophage Inflammatory Protein 2 (MIP-2), also known as CXCL2, is a small cytokine that is secreted by monocytes and neutrophils at sites of inflammation. MIP-2 functions through the chemokine receptor CXCR2 to act as a chemotactic agent for leukocytes and hematopoietic cells.
Fournisseur:
Shenandoah Biotechnology
Description:
Platelet-derived growth factor (PDGF) is an important regulator of cell growth, proliferation, and angiogenesis. PDGF synthesis is induced by IL-1, IL-6, TNF-α, TGF-β and EGF signaling. PDGF functions as a mitogenic growth hormone on cells of mesenchymal lineage, such as smooth muscle and glial cells.
Fournisseur:
Cayman Chemical
Description:
Leupeptin hemisulphate
Numéro de catalogue:
(RC-052)
Fournisseur:
G-Biosciences
Description:
Pig Native Gelatin (from Skin)
UOM:
1 * 100 g
Fournisseur:
Shenandoah Biotechnology
Description:
Fibroblast growth factor 8 (FGF-8) is a critical mitogenic factor that is required for normal development of the eye, ear, brain, and limb. FGF-8 functions broadly to promote cell proliferation, differentiation, and migration. Overexpression of FGF-8 increases tumor growth and angiogenesis. Human and mouse FGF-8 proteins show 100% homology.
Fournisseur:
Shenandoah Biotechnology
Description:
Interleukin 6 (IL-6) is a cytokine that is expressed by T cells, macrophages, and muscle cells. IL-6 acts to stimulate an immune response upon infection or trauma. IL-6 has both pro-inflammatory and anti-inflammatory functions, is capable of promoting fever, and signals through the cell-surface type I cytokine receptor complex containing the IL-6Ra and gp130 chains. Human IL-6 is active on mouse and rat cells.
Fournisseur:
Shenandoah Biotechnology
Description:
Interleukin 8 (IL-8 or CXCL8) is a member of the CXC cytokine family and is produced by macrophages, epithelial, smooth muscle, and endothelial cells. IL-8 binds the G protein-coupled serpentine receptors CXCR1 and CXCR2. IL-8 recruits innate immune cells, induces phagocytosis, and stimulates angiogenesis.
Fournisseur:
Shenandoah Biotechnology
Description:
Interleukin-1 receptor antagonist (IL-1RA) binds the interleukin 1 receptor (IL-1R) to antagonize interleukin 1 alpha and beta signaling. IL-1RA is secreted by immune cells, epithelial cells, hepatocytes, and adipocytes to inhibit IL-1-induced inflammation. IL-1RA therapy is used to treat auto-inflammatory diseases such as diabetes and rheumatoid arthritis.
Fournisseur:
Shenandoah Biotechnology
Description:
Interleukin 36 gamma (IL-36 ɣ) is a member of the interleukin 1 (IL-1) cytokine family and protects against pathogens in the skin, lung, and stomach epithelial barriers. IL-36 ɣ binds the interleukin-1 receptor accessory protein (IL-1RAcP) and the orphan IL-1R-related protein 2 (IL-1Rrp2) receptors to activate NF-kB and MAP kinase signaling pathways, resulting in the induced production of inflammatory cytokines and chemokines.
Fournisseur:
Shenandoah Biotechnology
Description:
Interleukin 4 (IL-4) is an immunomodulatory cytokine that functions to induce naïve helper T cells to differentiate into type 2 T helper (Th2) cells. Th2 cells subsequently produce more IL-4 in a positive feedback loop. IL-4 also promotes immunoglobulin IgG to IgE isotype switching on B cells. IL-4 binds the IL-4Rα receptor to activate STAT6 signaling.
Fournisseur:
Shenandoah Biotechnology
Description:
Glial cell-derived neurotrophic factor (GDNF) is a neurotrophic factor that signals through a multicomponent receptor system to activate receptor tyrosine kinase RET signaling. GDNF promotes dopamine uptake, prevents motor neuron apoptosis, and supports the survival and differentiation of neurons.
Fournisseur:
Shenandoah Biotechnology
Description:
Interleukin 12 (IL-12) is an inducer of cell-mediated immunity and is produced by dendritic cells, macrophages, and B cells after antigen stimulation. IL-12 functions to promote naïve T cell differentiation into the type 1 T helper cell (Th1) lineage. IL-12 also stimulates the production of interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) from T cells and natural killer cells. Mouse IL-12 is active on human and mouse cells.
Fournisseur:
Shenandoah Biotechnology
Description:
Interleukin 1 beta (IL-1β) is a pro-inflammatory cytokine that is produced by monocytes, macrophages, and dendritic cells (DCs). IL-1β signals through the IL-1 receptor, type 1 (IL-1R1) to activate the myeloid differentiation primary response 88 (MYD88) signaling pathway, which contains the cytoplasmic Toll/IL-1 receptor (TIR) domain adapter. IL-1β and the independently regulated IL-1α protein have overlapping proinflammatory activities to induce adhesion molecule expression on epithelial cells, control fever induction, initiate rheumatoid arthritis, and promote septic shock.
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