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Protéines et Peptides
Numéro de catalogue:
(PRSI92-723)
Fournisseur:
ProSci Inc.
Description:
Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have been associated with susceptibility to systemic lupus erythematosus(SLE), Gravesdisease(GRD), Celiac disease type3(CELIAC3) and Hepatitis B virus infection(HBVinfection).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-721)
Fournisseur:
ProSci Inc.
Description:
Mouse Interleukin 1 receptor, type II (IL1R2) is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I (IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. IL-1R2 structurally consisting of a ligand binding portion comprised of three Ig-like domains, a single transmembrane region, and a short cytoplasmic domain. It is expressed in a variety of cell types including B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Mouse IL1RII shares 59% amino acid sequence homology with human IL1 RII in their extracellular domains. The pleiotropic cytokine IL1 is produced to regulate development and maintenance of the inflammatory responses, and binds to specific plasma membrane receptors on cells. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R1 contributes to IL-1 signalling, whereas the IL-1R2 has no signalling property and acts as a decoy for IL-1.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6039P)
Fournisseur:
ProSci Inc.
Description:
APBA2 peptide is used for blocking the activity of APBA2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6033P)
Fournisseur:
ProSci Inc.
Description:
PIWI-L3 peptide is used for blocking the activity of PIWI-L3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3777P)
Fournisseur:
ProSci Inc.
Description:
Beta-actin peptide is used for blocking the activity of beta-actin antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7425P)
Fournisseur:
ProSci Inc.
Description:
19 amino acids near the carboxy terminus of FGFR3.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5761P)
Fournisseur:
ProSci Inc.
Description:
RBBP8 peptide is used for blocking the activity of RBBP8 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6133P)
Fournisseur:
ProSci Inc.
Description:
ZMYM1 peptide is used for blocking the activity of ZMYM1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6137P)
Fournisseur:
ProSci Inc.
Description:
ZMYM3 peptide is used for blocking the activity of ZMYM3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-564)
Fournisseur:
ProSci Inc.
Description:
Mouse Chordin-Like 2, also known as CHL2, is a novel chordin family member with structural homology to CHL1 which is implicated in tumour angiogenesis. The mouse CHL2 gene encodes a 426 amino acids (aa) protein with a 25 aa signal peptide. The mature chain of CHL2 protein contains two potential N-linked glycosylation sites, one putative NLS and three 63 aa cysteine-rich von Willebrand type C repeats (CRs). CHL2 gene is weakly expressed in the liver and kidney, partly expressed in the connective tissues of reproductive organs such as ligaments of the ovary and oviduct in females, and of testis, epididymis and certain male accessory sex glands in males. Recombinant mCHL2 protein interacted directly with five BMPs and one GDF thereby inhibiting, in vitro, several BMP/GDF-dependent processes including, osteogenic differentiation of C2C12 mesenchymal progenitor cells by several BMPs, ATDC5 embryonal carcinoma cells by GDF5 and BMP4-dependent lymphohematopoietic (CD34+CD31hi and CD34+CD31lo) progenitor cell development from ES cells. CHL2 may inhibits BMPs activity by blocking their interaction with their receptors, and has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation. Also, it may play a role during myoblast and osteoblast differentiation, and maturation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-001)
Fournisseur:
ProSci Inc.
Description:
As an adaptor protein, Growth Factor Receptor-Bound Protein 2 (GRB2) is involved in siganl transduction and consists of a central SH2 domain flanked by two SH3 domains. GRB2 associates with activated Tyr-phosphorylated EGF receptor/EGFR and PDGF receptors via its SH2 domain, stimulating GTP binding to Ras, which in turn activates MAPK and other signaling pathway.It also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, IRS4, SHC and LNK. probably via the concerted action of both its SH2 and SH3 domains.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4929P)
Fournisseur:
ProSci Inc.
Description:
JPH2 peptide is used for blocking the activity of JPH2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4923P)
Fournisseur:
ProSci Inc.
Description:
JPH4 peptide is used for blocking the activity of JPH4 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-022)
Fournisseur:
ProSci Inc.
Description:
Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ALK1 gene. ALK1 is a receptor in the TGF beta signaling pathway. ALK1 protein is a receptor in the TGF beta signaling pathway. It plays an important role in vascular development, remodeling, and pathologic angiogenesis, play a role in stabilizing angiogenic vessels and contribute to resistance to anti-VEGF therapies, ALK1 blockade may represent an effective therapeutic opportunity complementary to the current antiangiogenic modalities in the clinic. Recently, researcher found that, ALK1-Fc inhibited BMP9-mediated Id-1 expression in human umbilical vein endothelial cells and inhibited cord formation by these cells on a Matrigel substrate, in a chick chorioallantoic membrane assay, ALK1-Fc reduced vascular endothelial growth factor-, fibroblast growth factor-, and BMP10-mediated vessel formation, and ALK1-Fc treatment reduced tumor burden in mice receiving orthotopic grafts of MCF7 mammary adenocarcinoma cells.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-040)
Fournisseur:
ProSci Inc.
Description:
β2 microglobulin is also known as Beta-2-microglobulin (B2M), is a component of MHC class I molecules which belongs to the beta-2-microglobulin family. B2M is present on all nucleated cells (excludes red blood cells). B2M associates not only with the alpha chain of MHC class I molecules, but also with class I-like molecules such as CD1 and Qa. An additional function of B2M is association with the HFE protein, together regulating the expression of hepcidin in the liver which targets the iron transporter ferroportin on the cytoplasmic membrane of enterocytes and macrophages for degradation resulting in decreased iron uptake from food and iron release from recycled red blood cells respectively. Loss of this function causes iron excess and hemochromatosis. Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP).
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI92-582)
Fournisseur:
ProSci Inc.
Description:
Exostosin-like 2 (EXTL2) is a member of the exostosin (EXT)-related family which contains five members: EXT1, EXT2, EXTL1, EXTL2, and EXTL3. Studies have shown that EXT gene family members have the activities of heparan sulphate-synthesising glycosyltransferases. EXT1 and EXT2, which have been identified as causal genes for hereditary multiple exostoses, have HS-GlcAT-II and GlcNAcT-II activities. EXTL1 has GlcNAcT-II activity and EXTL3 has GlcNAcT-I and -II activities. EXTL2 has GlcNAcT-I and N-acetylgalactosaminyltransferase activities, and transfers a GlcNAc residue to the tetrasaccharide linkage region when this region is phosphorylated by a xylose kinase 1 (FAM20B) and thereby terminate chain elongation. In mice, lack of EXTL2 causes glycosaminoglycan (GAG) overproduction and structural changes of GAGs associated with pathological processes.
UOM:
1 * 50 µG
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