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Protéines et Peptides
Numéro de catalogue:
(PRSI6169P)
Fournisseur:
ProSci Inc.
Description:
LRRTM2 peptide is used for blocking the activity of LRRTM2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6125P)
Fournisseur:
ProSci Inc.
Description:
ZBTB6 peptide is used for blocking the activity of ZBTB6 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-603)
Fournisseur:
ProSci Inc.
Description:
Tissue Inhibitor of Metalloproteinases 1 (TIMP-1) complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13, and MMP-16. TIMP-1 does not act on MMP-14.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-436)
Fournisseur:
ProSci Inc.
Description:
Mouse B7-H2, also called CD275, B7RP-1, B7h, LICOS and GL50, is a member of the growing B7 family of immune costimulatory proteins. CD275 has been identified as the ligand for ICOS, a member of the CD28 family of co-stimulatory receptors. Mouse CD275 is expressed on resting B cells and at low levels on monocytes. The CD275/ ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-047)
Fournisseur:
ProSci Inc.
Description:
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-050)
Fournisseur:
ProSci Inc.
Description:
Nicotinamide phosphoribosyltransferase (Nampt; pre-B cell colony-enhancing factor; PBEF; Visfatin) is an adipokine that is localised to the bloodstream and has various functions, including the promotion of vascular smooth muscle cell maturation and inhibition of neutrophil apoptosis. It activates insulin receptor and has insulin-mimetic effects, lowering blood glucose and improving insulin sensitivity. The protein is highly expressed in visceral fat and serum levels of the protein correlate with obesity.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-457)
Fournisseur:
ProSci Inc.
Description:
HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-kappaB inducing localised innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also causative agent of various diseases as it causes localised inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis.
UOM:
1 * 25 µG
Numéro de catalogue:
(PRSI6977P)
Fournisseur:
ProSci Inc.
Description:
NDFIP1 peptide is used for blocking the activity of NDFIP1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6957P)
Fournisseur:
ProSci Inc.
Description:
TCTEX1D4 peptide is used for blocking the activity of TCTEX1D4 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6983P)
Fournisseur:
ProSci Inc.
Description:
ANG peptide is used for blocking the activity of ANG antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-016)
Fournisseur:
ProSci Inc.
Description:
Human TNFSF10 is a type II transmembrane protein with an intracellular N-terminus and a ‘TNF homology domain’ (THD) at the extracellular C terminus. TNFSF10 can interact with several distinct receptors. Two of these receptors that belongs to TNFR superfamily, DR4 (TRAIL-R1) and DR5 (TRAIL-R2/TRICK2), are plasma membrane proteins containing intracellular death domains essential for activating apoptosis. TNFSF10 is promising for cancer therapy because it is cytotoxic and activates apoptosis in the majority of malignant cells, but not in normal cells.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4655P)
Fournisseur:
ProSci Inc.
Description:
LIMP2 peptide is used for blocking the activity of LIMP2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6187P)
Fournisseur:
ProSci Inc.
Description:
RBM35B peptide is used for blocking the activity of RBM35b antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3367P)
Fournisseur:
ProSci Inc.
Description:
SIGIRR peptide is used for blocking the activity of the SIGIRR antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-528)
Fournisseur:
ProSci Inc.
Description:
Interleukin-27 (IL-27) is a heterodimeric group 2 receptor ligand molecule that belongs to the IL-6/IL-12 family of long type I cytokines. It is composed of EBI3 (EBV-induced gene 3), a 34 kDa glycoprotein that is related to the p40 subunit of IL-12 and IL-23, and p28, the cloned 28 kDa glycoprotein that is related to the p35 chain of IL-12. IL-27 is expressed by monocytes, endothelial cells and dendritic cells. IL-27 binds to and signals through a heterodimeric receptor complex composed of WSX1 (TCCR) and gp130. Evidence suggests IL-27 interacts only with WSX-1. IL-27 has both anti- and proinflammatory properties. As an antiinflammatory, IL-27 seems to induce a general negative feedback program that limits T and NK-T cell activity. At the onset of infection, IL-27 induces an IL-12 receptor on naie CD4+ T cells, making them susceptible to subsequent IL-12 activity (and possible Th1 development). Notably, IL-12 family cytokines are both induced and inhibited by bacterial products. Microbes promote IL-27 secretion through TLR4, and also block IL-27 production via C5a induction.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-523)
Fournisseur:
ProSci Inc.
Description:
Interleukin-22 (IL-22), also known as IL-10 related T cell-derived-inducible factor (ILTIF) was initially identified as a gene induced by IL-9 in mouse T cells and mast cells. IL-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. IL-22 is produced by normal T cells upon anti-CD3 stimulation in humans. Mouse IL-22 expression is also induced in various organs upon lipopolysaccharide injection, suggesting that IL-22 may be involved in inflammatory responses. The functional IL-22 receptor complex consists of two receptor subunits, IL-22R(CRF29) and IL-10Rbeta(CRF24), belonging to the class II cytokine receptor family.
UOM:
1 * 1 EA
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