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Protéines et Peptides
Numéro de catalogue:
(401799-1)
Fournisseur:
Merck Millipore (Oncogene)
Description:
Prepared from plasma shown to be nonreactive for HBsAg and for antibodies to HCV, HBc, HIV-1, and HIV-2.
UOM:
1 * 1 mg
Fournisseur:
Merck Millipore (Calbiochem)
Description:
Angiotensin II plays an important role in the regulation of blood pressure. Stimulates the release of aldosterone from the adrenal gland.
Numéro de catalogue:
(J63421.MB)
Fournisseur:
Thermo Scientific
Description:
Peptide hormone that acts predominantly as a neurotransmitter; stimulates uterine contraction and lactation.
UOM:
1 * 25 mg
Numéro de catalogue:
(J60915.03)
Numéro de catalogue:
(PRSI92-642)
Fournisseur:
ProSci Inc.
Description:
Epithelial Cell Adhesion Molecule (EpCAM) is a signal type I transmembrane glycoprotein that belongs to the EPCAM family. EpCAM is composed of an extracellular domain with one thyroglobulin type-1 domain, a transmembrane domain and a cytoplasmic domain. EpCAM is found on the surface of adenocarcinoma, but not on mesodermal or neural cell membranes. The EpCAM molecule has been shown to function as a homophilic Ca2+ independent adhesion molecule. It may act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium as an immunological barrier providing the first line of defence against infection. Defects in EPCAM are a cause of hereditary non-polyposis colorectal cancer type 8 (HNPCC8) and diarrhoea type 5 (DIAR5). EpCAM plays a role in embryonic stem cells proliferation and differentiation; it up-regulates the expression of FABP5, MYC and Cyclin A and Cyclin E. It is highly and selectively expressed by undifferentiated embryonic stem cells.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-644)
Fournisseur:
ProSci Inc.
Description:
Mesothelin is a cell surface glycoprotein whose expression is limited to mesothelial cells of the serosa (pleura, pericardium, and peritoneum) and epithelial cells of the trachea, tonsils, fallopian tube, and kidneys. Mesothelin plays an important role in cell survival, proliferation, migration, invasion, tumor progression, and resistance to chemotherapy. The overexpression of mesothelin can activate NF-κB and signal transducer and activator of transcription 3 (Stat3), inhibit apoptotic signaling and TNF- alpha-induced apoptosis, and accelerate the G1–S transition. Mesothelin is also found overexpressed in various cancers, including malignant mesothelioma, pancreatic or ovarian carcinoma, sarcomas and in some gastrointestinal or pulmonary carcinomas. As a result of its limited expression in normal tissues, mesothelin has been reported as an ideal tumor-associated marker for the development of targeted therapy.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-514)
Fournisseur:
ProSci Inc.
Description:
CD300A is a single-pass type I membrane protein that belongs to the CD300 family. CD300A consists of a 163 amino acid (aa) extracellular domain (ECD) with one Ig-like V- type domain, a 21 amino acid transmembrane segment, and a 98 amino acid cytoplasmic domain with tyrosine residues. CD300A is expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes. CD300A is an inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-730)
Fournisseur:
ProSci Inc.
Description:
Tumor necrosis factor receptor superfamily member 21 (TNFRSF21) is also known as death receptor 6 (DR6), which is a member of the TNF-receptor superfamily. TNFRSF21 contains one death domain and four TNFR-Cys repeats. TNFRSF21 / DR6 has been shown to activate NF-κB and MAPK8/JNK, and induce cell apoptosis. Through its death domain, this receptor interacts with TRADD protein, which is known to serve as an adaptor that mediates signal transduction of TNF-receptors.
UOM:
1 * 200 µG
Numéro de catalogue:
(PRSI90-427)
Fournisseur:
ProSci Inc.
Description:
T cells require a signal induced by the engagement of the T cell receptor and a costimulatory signal(s) through distinct T cell surface molecules for optimal T cell activation and tolerance. CD273 (PD-L2) is one of two ligands for programmed death-1 (PD-1; CD279), a member of the CD28 family of immunoreceptors. The other identified ligand is PD-L1. CD273 is broadly expressed and also up regulated in a variety of tumour cell lines. On previously activated T cells, CD273 interaction with PD-1 inhibits TCR mediated proliferation and cytokine production, suggesting an inhibitory role in regulating immune responses. CD273 has a costimulatory function on resting T cells activated with suboptimal TCR signals.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-446)
Fournisseur:
ProSci Inc.
Description:
CD278, also called inducible costimulator (ICOS) or CRP1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI2089P)
Fournisseur:
ProSci Inc.
Description:
CIDE-A peptide is used for blocking the activity of mCIDE-A antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6097P)
Fournisseur:
ProSci Inc.
Description:
ZIP9 peptide is used for blocking the activity of ZIP9 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6093P)
Fournisseur:
ProSci Inc.
Description:
ZIP7 peptide is used for blocking the activity of ZIP7 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6217P)
Fournisseur:
ProSci Inc.
Description:
GLS2 peptide is used for blocking the activity of GLS2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6221P)
Fournisseur:
ProSci Inc.
Description:
LRRFIP2 peptide is used for blocking the activity of LRRFIP2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6493P)
Fournisseur:
ProSci Inc.
Description:
NEUCRIN peptide is used for blocking the activity of NEUCRIN antibody.
UOM:
1 * 50 µG
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