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Protéines et Peptides
Numéro de catalogue:
(PRSI2259P)
Fournisseur:
ProSci Inc.
Description:
Ski peptide is used for blocking activity of Ski antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-924)
Fournisseur:
ProSci Inc.
Description:
Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures and has been shown to act synergistically with colony stimulating factors.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-447)
Fournisseur:
ProSci Inc.
Description:
Programmed Death-1 (PD-1, CD279) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T-cells, B-cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signallling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-293)
Fournisseur:
ProSci Inc.
Description:
Fatty acid-binding protein 5 (FABP5), is also known as Fatty acid-binding protein, epidermal (E-FABP), Psoriasis-associated fatty acid-binding protein homolog (PA-FABP). FABP5 / E-FABP belongs to the calycin superfamily and fatty-acid binding protein (FABP) family. FABP5 / E-FABP is highly expressed in psoriatic skin. FABP5 / E-FABP has high specificity for fatty acids and has highest affinity for C18 chain length. FABP5 may be involved in keratinocyte differentiation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI92-627)
Fournisseur:
ProSci Inc.
Description:
Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene. Human Irisin is synthesized as a 212 amino acid (aa) precursor encoding a type 1 transmembrane protein with a 121 aa extracellular domain (ECD), a 21 aa transmembrane domain, and a 39 aa cytoplasmic domain. The ECD of Irisin contains a fibronectin type III domain and multiple glycosylation sites. The ECD is proteolytically cleaved to release the 112 aa soluble Irisin hormone into circulation. Mature human, mouse share 100% sequence identity. Irisin induces expression of peroxisome proliferator activated receptor gamma coactivator 1 alpha (PGC1 alpha) and uncoupling protein1(UCP1), mitochondrial associated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue. Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-810)
Fournisseur:
ProSci Inc.
Description:
Low affinity immunoglobulin gamma Fc region receptor III-B, also known as Fc-gamma RIII-beta, FcR-10, IgG Fc receptor III-1, FCG3, FCGR3, CD16b and FCGR3B. FCGR3B is a GPI-anchor membrane protein and contains two Ig-like C2 type domains. FCGR3B can be expressed in orphonuclear leukocytes and stimulated eosinophils. FCGR3B can interact with INPP5D/SHIP1. FCGR3B localizes in the FCGR gene cluster is a CN polymorphic gene involved in the recruitment of polymorphonuclear neutrophils to sites of inflammation and their activation. FCGR3B may serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-818)
Fournisseur:
ProSci Inc.
Description:
IL10RB is a single- pass type I membrane protein and contains two fibronectin type-III domains. It is an accessory chain which is essential for the active interleukin 10 receptor complex. Coexpression of IL10RB and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25) which is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-905)
Fournisseur:
ProSci Inc.
Description:
Human C-X-C Motif Chemokine Ligand 10 (CXCL10) is a non-ELR chemokine secreted by various cell types, such as monocytes, endothelial cells and fibroblasts, in response to IFN- gamma . CXCL10 functions via chemokine receptor CXCR3. CXCL10 has been attributed to several roles, such as chemoattraction for activated T-lymphocytes, inhibition of angiogenesis, and antitumor activity.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-913)
Fournisseur:
ProSci Inc.
Description:
CD83 antigen is a single-pass type I membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD83 is expressed by activated lymphocytes, Langerhans cells and interdigitating reticulum cells. It contains one Ig-like V-type (immunoglobulin-like) domain. , the soluble CD83 has the opposite effect and has an immune inhibitory capacity. Due to its immune inhibitory function, CD83 may play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-906)
Fournisseur:
ProSci Inc.
Description:
Clusterin is a secreted protein which belongs to the Clusterin family. Clusterin is expressed in adult testis, heart, ovary, adrenal gland, brain and liver. Clusterin has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. In addition,Clusterin is up/ down regulated on the mRNA or protein level in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-169)
Fournisseur:
ProSci Inc.
Description:
CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-163)
Fournisseur:
ProSci Inc.
Description:
Human recombinant Cd3D (from HEK293 cells)
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-153)
Fournisseur:
ProSci Inc.
Description:
Glycophorin-A, a member of the glycophorin-A family, is also known as CD235a and Gypa, which is heavily glycosylated on serine and threonine residues at the N-terminal extracellular domain. CD235a,a single-pass type III membrane protein,is the major intrinsic membrane sialoglycoprotein of the erythrocyte. Also,CD235a appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. Furthermore,CD235a may be involved in translocation of SLC4A1 to the plasma membrane.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-492)
Fournisseur:
ProSci Inc.
Description:
Mouse tumour necrosis factor ligand superfamily member 11(Tnfsf11) is a member of the tumour necrosis factor (TNF) cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such as thymus and lymph nodes. This cytokine can bind to TNFRSF11B/OPG andTNFRSF11A/RANK. Tnfsf11 is involved in a number of fundamental biological processes such as acting as regulator of interactions between T-cells and dendritic cells, the regulation of the T-cell-dependent immune response and enhancing bone-resorption in humoral hypercalcemia of malignancy. It augments the ability of dendritic cells to stimulate naive T-cell proliferation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6821P)
Fournisseur:
ProSci Inc.
Description:
PRC1 peptide is used for blocking the activity of PRC1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6795P)
Fournisseur:
ProSci Inc.
Description:
VKORC1 peptide is used for blocking the activity of VKORC1 antibody.
UOM:
1 * 50 µG
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