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Protéines et Peptides
Numéro de catalogue:
(PRSI5979P)
Fournisseur:
ProSci Inc.
Description:
CIITA peptide is used for blocking the activity of CIITA antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-124)
Fournisseur:
ProSci Inc.
Description:
DLL1 (Delta-like protein; Delta1) is essential for postnatal arteriogenesis and contributes to tumour progression. DLL1 is involved in differentiation and self-renewal of adipocyte stem cells. Blocks the differentiation of progenitor cells into the B cell lineage while promoting the emergence of a population of cells with the characteristics of a T cell/NK-cell precursor.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3337P)
Fournisseur:
ProSci Inc.
Description:
Bcl-2 peptide is used for blocking the activity of Bcl-2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3321P)
Fournisseur:
ProSci Inc.
Description:
PIKE peptide is used for blocking the activity of Anit-PIKE antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3445P)
Fournisseur:
ProSci Inc.
Description:
Caspase-3 peptide is used for blocking the activity of Caspase-3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-478)
Fournisseur:
ProSci Inc.
Description:
Interleukin-4 (IL-4) is a cytokine produced by type 2 helper T cells, the Th2 cells. These cells tends to make a specific set of lymphokines including IL-4, IL-5, IL-6, IL-10, IL-13, IL-3 and GM-CSF and fail to produce IL-2, IFN-gamma, and lymphotoxin (TNF-beta). In addition, mast cells can produce IL-4. IL-4 exerts numerous effects on various hematopoietic cell types. On B cells, IL-4 promotes immunoglobulin class switching to IgE and IgG1 isotypes and upregulates MHC class II and CD23 expression. IL-4 promotes survival, growth, and differentiation of both T and B lymphocytes, mast cells and endothelial cells. In addition, IL-4 inhibits the production of TNF, IL-1, and IL-6 by macrophages.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-474)
Fournisseur:
ProSci Inc.
Description:
Interleukin-4 (IL-4) is a cytokine produced by type 2 helper T cells, the Th2 cells. These cells tends to make a specific set of lymphokines including IL-4, IL-5, IL-6, IL-10, IL-13, IL-3 and GM-CSF and fail to produce IL-2, IFN-gamma, and lymphotoxin (TNF-beta). In addition, mast cells can produce IL-4. IL-4 exerts numerous effects on various hematopoietic cell types. On B cells, IL-4 promotes immunoglobulin class switching to IgE and IgG1 isotypes and upregulates MHC class II and CD23 expression. IL-4 promotes survival, growth, and differentiation of both T and B lymphocytes, mast cells and endothelial cells. In addition, IL-4 inhibits the production of TNF, IL-1, and IL-6 by macrophages.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-483)
Fournisseur:
ProSci Inc.
Description:
Interleukin 6 (IL-6) is a pleiotropic alpha-helical cytokine that plays important roles in acute phase reactions, inflammation, hematopoiesis, bone metabolism and cancer progression. IL-6 activity is essential for the transition from acute inflammation to either acquired immunity or chronic inflammatory disease. It is secreted by multiple cell types as a 22kDa-28kDa phosphorylated and variably glycosylated molecule. IL-6 induces signallling through a cell surface heterodimeric receptor complex composed of a ligand binding subunit (IL-6R) and a signal transducing subunit (gp130). IL-6 is a key factor for the growth of plasma cells.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3039P)
Fournisseur:
ProSci Inc.
Description:
AATF peptide is used for blocking the activity of AATF antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-798)
Fournisseur:
ProSci Inc.
Description:
Activin Receptor Type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor. This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-802)
Fournisseur:
ProSci Inc.
Description:
The class 4 semaphorins are integral membrane proteins that are widely expressed throughout the nervous system. SEMA4B is a single-pass type I membrane protein and contains one Ig-like C2-type (immunoglobulin-like) domain, one PSI domain and one Sema domain. Human SEMA4B is expressed in neurons. SEMA4B inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. SEMA4B negatively regulates basophil-mediated Th2 and humoral memory responses.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-796)
Fournisseur:
ProSci Inc.
Description:
SELE is expressed on the surface of endothelial cells and mediates the interaction of leukocytes and platelets with endothelial cells during an inflammatory response. SELE functions as a cell-surface glycoprotein and has a role in immunoadhesion. In addition, SELE may also have a role in capillary morphogenesis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6025P)
Fournisseur:
ProSci Inc.
Description:
MFSD2A peptide is used for blocking the activity of MFSD2A antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-286)
Fournisseur:
ProSci Inc.
Description:
Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin). Irisin is cleaved from the type I membrane protein FNDC5 and improves systemic metabolism by increasing energy expenditure.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-294)
Fournisseur:
ProSci Inc.
Description:
BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases such as Sjoegren syndrome, Rheumatoid arthritis (RA), Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE). BAFF has also increased levels in some lymphoid cancers. Processed human BAFF can either remain as a trimer, which is usual for TNF family ligands or assemble into 60-mer composed of 20 trimers. Mouse BAFF 60-mer has been identified in the serum of BAFF transgenic mice. Oligomerisation of BAFF 3-mer into 60-mer in human BAFF is prevented by mutation of His218, a residue critical for 3-mer-to-3-mer interactions, but not for receptor binding. Despite the predominant functional role of processed BAFF in vivo, membrane-bound BAFF might also play a role. Indeed, soluble BAFF (3-mer) can trigger BAFF-R but not TACI or BCMA, whereas oligomeric forms of BAFF (BAFF 60-mer), which mimic membrane-bound BAFF, activate all BAFF receptors.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI91-141)
Fournisseur:
ProSci Inc.
Description:
Protein Phosphatase 1A (PPM1A) is a member of the PP2C family of Ser/Thr protein phosphatases which are known to be negative regulators of cell stress response pathways. PPM1A has a broad specificity. PPM1A negatively regulates the activities of MAP kinases and MAP kinase kinases. Also, it negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. In addition, PPM1A can dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control.
UOM:
1 * 50 µG
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