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Protéines et Peptides
Numéro de catalogue:
(PRSI90-459)
Fournisseur:
ProSci Inc.
Description:
HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-kappaB inducing localised innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also causative agent of various diseases as it causes localised inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis.
UOM:
1 * 25 µG
Numéro de catalogue:
(PRSI90-454)
Fournisseur:
ProSci Inc.
Description:
Decoy receptor 3 (DcR3; TNFRSF6B; M68) is a member of the TNF receptor superfamily. DcR3 shares sequence identity with OPG (31%), TNF-RII (29%) and Fas (17%) and is expressed in a variety of different tissues and at high levels in many malignant tumours. Ligands of DcR3 include Fas ligand, homologous to lymphotoxin showing inducible expression and competing with HSV glycoprotein D for herpes virus entry mediator (a receptor expressed by T lymphocytes), TNF-like molecule 1A and heparan sulfate proteoglycans. DcR3 modulates the function of T cells, dendritic cells and macrophages. DcR3/Fc fusion proteins can bind to human and mouse B cells and suppress the activation of B cells.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI92-322)
Fournisseur:
ProSci Inc.
Description:
L-Selectin is a member of a family of Selectin that is transiently expressed on vascular endothelial cells in response to IL-1 beta and TNF-alpha. L-Selectin (Leukocyte Selectin, LAM-1, LECAM-1, LECCAM-1, TQ1, Leu-8, MEL-14 antigen, DREG, lymph node homing receptor, CD62L) is expressed constitutively on a wide variety of leukocytes and mediates a number of leukocyte-endothelial interactions, including the binding of lymphocytes to HEV of peripheral lymph node high endothelial venules (HEV), neutrophil rollling, and leukocyte attachment to cytokine-treated endothelium in vitro.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-317)
Fournisseur:
ProSci Inc.
Description:
CTGF belongs to the CCN (CTGF/Cyr61/Cef10/NOVH) protein family, which is comprised of six secreted proteins that reside in the extracellular matrix (ECM). CTGF causes a variety of cellular responses including reduced cell adhesion and enhanced cell migration and proliferation. CTGF has also been shown to be essential for epithelial to mesenchymal transition (EMT), a process whereby normal functioning cells morph into ones that produce mainly scar tissue (of which collagen in the major protein component).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-191)
Fournisseur:
ProSci Inc.
Description:
Human recombinant Clusterin (from HEK293 cells)
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI91-454)
Fournisseur:
ProSci Inc.
Description:
TIE-1 (Tyrosine Kinase with Ig and EGF Homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily. These receptors are expressed on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18aa signal peptide, a 727 aa extracellular domain and a 354 aa cytoplasmic domain. so far, two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2)], but no ligand was found for TIE-1.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-503)
Fournisseur:
ProSci Inc.
Description:
Lysosomal-associated membrane protein 1 (LAMP1) is also known as CD107a (Cluster of Differentiation 107a). LAMP1 / CD107a belongs to the LAMP family. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. CD107a has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-251)
Fournisseur:
ProSci Inc.
Description:
RANKL is an osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T cell proliferation. Important regulator of interactions between T cells and dendritic cells and may play a role in the regulation of the T cell-dependent immune response. RANKL plays an important role in the progression of Breast cancer.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3285P)
Fournisseur:
ProSci Inc.
Description:
TLR11 peptide is used for blocking the activity of the TLR11 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3251P)
Fournisseur:
ProSci Inc.
Description:
TRIM5 alpha peptide is used for blocking the activity of the TRIM5 alpha antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3279P)
Fournisseur:
ProSci Inc.
Description:
TLR8 peptide is used for blocking the activity of TLR8 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3405P)
Fournisseur:
ProSci Inc.
Description:
Bim peptide is used for blocking the activity of Bim antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3385P)
Fournisseur:
ProSci Inc.
Description:
TAK1 peptide is used for blocking the activity of TAK1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3373P)
Fournisseur:
ProSci Inc.
Description:
UBC13 peptide is used for blocking the activity of the UBC13 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4679P)
Fournisseur:
ProSci Inc.
Description:
SATB1 peptide is used for blocking the activity of SATB1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4599P)
Fournisseur:
ProSci Inc.
Description:
TNPO3 peptide is used for blocking the activity of TNPO3 antibody.
UOM:
1 * 50 µG
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