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Protéines et Peptides
Numéro de catalogue:
(PRSI91-320)
Fournisseur:
ProSci Inc.
Description:
IGFBP-4, whose full name is insulin-like growth factor-binding protein 4, is induced by forskolin and N6, O2’dibutyryl sdenosine 3’, or 5’-cyclic monophosphate. It contains IGFBP N-terminal domain and thyroglobulin type-1 domain, and can bind IGF2. The IGF-binding proteins can prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-329)
Fournisseur:
ProSci Inc.
Description:
The Interferon- alpha/ beta Receptor 1 (IFN- alpha/ beta R1) is a receptor which binds Type I Interferons including Interferon- alpha and - beta . It is a cell surface receptor and heteromeric receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2. IFN- alpha/ beta R1, in association with IFN- alpha/ beta R2, is required for propagating antiviral signal transduction triggered by IFN- alpha and IFN- beta . IFN- alpha/ beta R1 interacts very weakly or not at all with type 1 interferons and does not stably interact with IFN- alpha/ beta R2. Ligands associate with IFN- alpha/ beta R2, and this complex subsequently forms a stable ternary assembly with IFN- alpha/ beta R1. IFN- alpha/ beta R1 also associates with IFN- gamma R2 even in the absence of IFN- gamma stimulation. Human IFN- alpha/ beta R1 contains a nuclear localization signal in its extracellular domain that is required for receptor translocation to the nucleus following interaction with ligand. Interferon stimulation results in an immunologic response that is especially associated with viruses.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3391P)
Fournisseur:
ProSci Inc.
Description:
TAB3 peptide is used for blocking the activity of TAB3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5859P)
Fournisseur:
ProSci Inc.
Description:
CaBP7 peptide is used for blocking the activity of CaBP7 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5861P)
Fournisseur:
ProSci Inc.
Description:
CaBP8 peptide is used for blocking the activity of CaBP8 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI40-537)
Fournisseur:
ProSci Inc.
Description:
TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant rat TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI5415P)
Fournisseur:
ProSci Inc.
Description:
IA-1 peptide is used for blocking the activity of IA-1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4625P)
Fournisseur:
ProSci Inc.
Description:
SAPAP2 peptide is used for blocking the activity of SAPAP2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7383P)
Fournisseur:
ProSci Inc.
Description:
19 amino acids near the center of human TRIM24.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-510)
Fournisseur:
ProSci Inc.
Description:
B- and T-Lymphocyte Attenuator (BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type (immunoglobulin-like) domain. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a lymphocyte inhibitory receptor that inhibits lymphocytes during immune response. BTLA also is a ligand for tumor necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-501)
Fournisseur:
ProSci Inc.
Description:
Adiponectin is a secreted protein. It is synthesized exclusively by adipocytes and secreted into plasma. Adiponectin is an important adipokine that is involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Adiponectin Stimulates AMPK phosphorylation and activates in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Adiponectin also antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. It inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. Adiponectin may play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex: LMW, MMW or HMW.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-502)
Fournisseur:
ProSci Inc.
Description:
Anterior Gradient Protein 2(AG-2) and Anterior Gradient Protein 3 (AG-3) are human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan (hAG-3 protein). AG-3 could serve as a prognostic marker for survival in patients with low grade and high grade serous ovarian carcinomas.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3647P)
Fournisseur:
ProSci Inc.
Description:
TLR5 peptide is used for blocking the activity of TLR5 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-774)
Fournisseur:
ProSci Inc.
Description:
Activin receptor type-1, also known as Activin receptor type I, Activin receptor-like kinase 2, Serine/threonine-protein kinase receptor R1, TGF-B superfamily receptor type I, ACVRLK2 and ACVR1, is a single-pass type I membrane protein. ACVR1 is expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. ACVR1 belongs to the protein kinase superfamily. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 signals a particular transcriptional response in concert with activin type II receptors.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-768)
Fournisseur:
ProSci Inc.
Description:
CD99 Antigen-Like Protein 2 (CD99L2) belongs to the CD99 family. CD99L2 is a single-pass type I membrane protein and expressed in many tissues, with low expression in thymus. CD99L2 plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. CD99L2 and CD99 are involved in trans-endothelial migration of neutrophils in vitro and in the recruitment of neutrophils into inflamed peritoneum. A similar protein in mouse functions as an adhesion molecule during leukocyte extravasation. Alternate splicing results in multiple transcript variants.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-770)
Fournisseur:
ProSci Inc.
Description:
Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can be down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells. Soluble Ephrin-A1 is necessary for the transformation of HeLa and SK-BR3 cells and participates in the relocalization of EPHA2 away from sites of cell-cell contact during transformation. Ephrin-A1 plays an important role in angiogenesis and tumor neovascularization.
UOM:
1 * 50 µG
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