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Protéines et Peptides
Numéro de catalogue:
(PRSI5499P)
Fournisseur:
ProSci Inc.
Description:
MARVELD1 peptide is used for blocking the activity of MARVELD1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI1128P)
Fournisseur:
ProSci Inc.
Description:
Caspase-10 peptide is used for blocking the activity of caspase-10 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI1123P)
Fournisseur:
ProSci Inc.
Description:
Eotaxin peptide is used for blocking the activity of eotaxin antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI1133P)
Fournisseur:
ProSci Inc.
Description:
GFR alpha 1 peptide is used for blocking the activity of GFR alpha 1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI1125P)
Fournisseur:
ProSci Inc.
Description:
SIRP alpha peptide is used for blocking the activity of SIRP alpha antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4885P)
Fournisseur:
ProSci Inc.
Description:
MARCH8 peptide is used for blocking the activity of MARCH8 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4035P)
Fournisseur:
ProSci Inc.
Description:
DRAM peptide is used for blocking the activity of DRAM antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-950)
Fournisseur:
ProSci Inc.
Description:
Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-939)
Fournisseur:
ProSci Inc.
Description:
Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development, cell proliferation and differentiation. HER2 has been reported to associate with malignancy and a poor prognosis in numerous carcinomas, including breast, prostate, ovarian, lung cancers and so on. HER2 is activated by dimerization and not activated by EGF, TGF-alpha and amphiregulin. Interaction with PTK6 increases its intrinsic kinase activity.It is heterodimer with EGFR, ERBB3 and ERBB4. HER2 associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. It implicated in transcriptional activation of CDKN1A and the function of the protein involves STAT3 and SRC. And also it involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-954)
Fournisseur:
ProSci Inc.
Description:
RSPO1 is a secreted protein,containing 2 FU(furin-like) repeats and 1 TSP type-1 domain and belonging to the R-spondin family. RSPO1 is required for the early development of gonads, regardless of sex. It has been found in mice only eleven days after fertilization. To induce cell proliferation, it acts synergistically with WNT4. They help stabilize beta catenin, which activates downstream targets. RSPO1 is necessary in female sex development. It augments the WNT/ beta catenin pathway to oppose male sex development. In critical gonadal stages, between six and nine weeks after fertilization, the ovaries upregulate it while the testes downregulate it. RSPO1 can potentially aid in the treatment of mucositis, which is characterized by inflammation of the oral cavity. This unfortunate condition often accompanies chemotherapy and radiation in cancer patients with head and neck tumors.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-952)
Fournisseur:
ProSci Inc.
Description:
T-cell-specific surface glycoprotein CD28(CD28) is a single-pass typeI membrane protein which contains one Ig-likeV-type (immunoglobulin-like) domain. It belongs to the immunoglobulin(Ig) superfamily. CD28 is one of the molecules expressed on T cells that provide co-stimulatory signals, which are required for T cell activation.CD28 co-stimulation is necessary for CD4 positive T-cell proliferation and survival, interleukin-2 production, and T-helper type-2 development. Human post-thymic regulatory T cells require CD28 co-stimulation to expand and maintain potent suppressive function in vivo. Apoptosis plays a key role in the age-related decline of CD28 expression and in immunosenescence. CD28 is the receptor for CD80 (B7.1) and CD86 (B7.2). When activated by Toll-like receptor ligands, the CD80 expression is upregulated in antigen presenting cells (APCs). The CD86 expression on antigen presenting cells is constitutive. CD28 is the only B7 receptor constitutively expressed on naive T cells.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-944)
Fournisseur:
ProSci Inc.
Description:
Mouse Vascular endothelial growth factor (VEGF or VEGFA), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. It is a member of the PDGF/VEGF growth factor family that is characterized by a cystine knot structure formed by eight conserved cysteine residues. Alternately spliced isoforms of 120, 164 and 188 aa found in mouse. VEGF binds the type I transmembrane receptor tyrosine kinases VEGF R1 (also called Flt1) and VEGF R2 (Flk/KDR) on endothelial cells.Although affinity is highest for binding to VEGF R1, VEGF R2 appears to be the primary mediator of VEGF angiogenic activity. VEGF is required during embryogenesis to regulate the proliferation, migration, and survival of endothelial cells.It may play a role in increasing vascular permeability during lactation, when increased transport of molecules from the blood is required for efficient milk protein synthesis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-945)
Fournisseur:
ProSci Inc.
Description:
Ephrin-A1 is a cell membrane protein and contains 1 ephrin RBD (ephrin receptor-binding) domain. EFNA1 belongs to the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis.It belongs to the ephrin family and contains 1 ephrin RBD (ephrin receptor-binding) domain.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5001P)
Fournisseur:
ProSci Inc.
Description:
ZIP11 peptide is used for blocking the activity of ZIP11 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4993P)
Fournisseur:
ProSci Inc.
Description:
KLRA3 peptide is used for blocking the activity of KLRA3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-509)
Fournisseur:
ProSci Inc.
Description:
Low-Density Lipoprotein (LDL) Receptor is also known as LDLR, FH, FHC, LDLCQ2, and is a mosaic protein of ~840 amino acids (after removal of signal peptide) that mediates the endocytosis of cholesterol-rich LDL. It is a cell-surface receptor that recognizes the apoprotein B100 which is embedded in the phospholipid outer layer of LDL particles. The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants (IDL). It belongs to the Low density lipoprotein receptor gene family. LDL receptor complexes are present in clathrin-coated pits (or buds) on the cell surface, which when bound to LDL-cholesterol via adaptin, are pinched off to form clathrin-coated vesicles inside the cell. This allows LDL-cholesterol to be bound and internalized in a process known as endocytosis and prevents the LDL just diffusing around the membrane surface. This occurs in all nucleated cells (not erythrocytes), but mainly in the liver which removes ~70% of LDL from the circulation. Synthesis of receptors in the cell is regulated by the level of free intracellular cholesterol; if it is in excess for the needs of the cell then the transcription of the receptor gene will be inhibited. LDL receptors are translated by ribosomes on the endoplasmic reticulum and are modified by the Golgi apparatus before travelling in vesicles to the cell surface. LDL is directly involved in the development of atherosclerosis, due to accumulation of LDL-cholesterol in the blood. Atherosclerosis is the process responsible for the majority of cardiovascular diseases.
UOM:
1 * 1 EA
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