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Protéines et Peptides
Numéro de catalogue:
(PRSI96-437)
Fournisseur:
ProSci Inc.
Description:
Interleukin-1 receptor type 2 (IL1R2) is also known as CD121 antigen-like family member B (CDw121b), IL-1 type II receptor, Interleukin-1 receptor type II, belongs to the interleukin-1 receptor family. Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB). IL1R2 is non-signaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-443)
Fournisseur:
ProSci Inc.
Description:
Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells). In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.
UOM:
1 * 20 µG
Numéro de catalogue:
(PRSI4777P)
Fournisseur:
ProSci Inc.
Description:
gp120 peptide is used for blocking the activity of presenilin1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-190)
Fournisseur:
ProSci Inc.
Description:
DNER is an activator of the Notch1 pathway. It mediates neuron-glia interaction during astrocytogenesis.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-539)
Fournisseur:
ProSci Inc.
Description:
Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 is a single-pass type I membrane protein. LYVE-1 is a CD44 homolog found primarily on lymphatic endothelial cells 1. LYVE-1 mainly expressed in endothelial cells lining lymphatic vessels. While LYVE-1 functions is a Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. LYVE-1 plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). It may act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-890)
Fournisseur:
ProSci Inc.
Description:
CD300C is a single-pass type I membrane protein which belongs to the immunoregulatory signaling (IRS) family. CD300C contains one Ig-like V-type domain and is present on the surface of natural killer cells, granulocytes, most myeloid cells, dendritic cells, and a subpopulation of T and B lymphocytes. The CD300C (CMRF-35A) and CD300A (CMRF-35H) molecules are homologous leukocyte surface proteins. CD300a and CD300C play an important role in the cross-regulation of TNF-alpha and IFN-alpha secretion from pDCs. CD300A and CD300C are indistinguishable on the surface of NK cells. The ligand for CD300C is presently unknown.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4775P)
Fournisseur:
ProSci Inc.
Description:
PRTFDC1 peptide is used for blocking the activity of PRTFDC1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3643P)
Fournisseur:
ProSci Inc.
Description:
TLR3 peptide is used for blocking the activity of TLR3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3645P)
Fournisseur:
ProSci Inc.
Description:
TLR3 peptide is used for blocking the activity of TLR3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5591P)
Fournisseur:
ProSci Inc.
Description:
BFAR pepide is used for blocking the activity of BFAR antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7257P)
Fournisseur:
ProSci Inc.
Description:
16 amino acids near the center of human FOXA2.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7255P)
Fournisseur:
ProSci Inc.
Description:
17 amino acid peptide near the center of human FOXA1.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-367)
Fournisseur:
ProSci Inc.
Description:
Cathepsin E (CTSE) is a gastric aspartyl protease that functions as a disulfide-linked homodimer. It is a member of the Peptidase C1 family, and has a specificity similar to that of Pepsin A and Cathepsin D. CTSE is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome. It is expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. CTSE is an intracellular proteinase that have a role in immune function, activation-induced lymphocyte depletion in the thymus, neuronal degeneration and glial cell activation in the brain. Futhermore, it probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-361)
Fournisseur:
ProSci Inc.
Description:
Vasorin is a Type I membrane protein, which is predominantly expressed in vascular smooth muscle cells in a developmentally regulated pattern. The expression level of Vasorin can be down regulated during vessel repair after arterial injury. Vasorin binds to transforming growth factor beta (TGF- beta ) and attenuates TGF- beta signaling in vitro.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-358)
Fournisseur:
ProSci Inc.
Description:
Triggering Receptor Expressed on Myeloid Cells-Like Protein 1 (TREML1) is a single-pass type I membrane protein. TREML1 precursor contains a 15 amino acid signal peptide, a 147 amino acid extracellular domain with an Ig-like V-type (immunoglobulin-like) domain, and 128 amino acid cytoplasmic domain. It can be expressed exclusively in platelets and megakaryocytes (MKs). It is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML1 Sequestered in cytoplasmic vesicles in resting platelets. TREML1 be transported to the cell surface after stimulation by thrombin. Soluble fragments can be released into the serum by proteolysis. The phosphorylated TREML1 can interact with PTPN6 and PTPN11. TREML1 may participate in maintaining vascular hemostasis and regulating coagulation and inflammation at sites of injury.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-212)
Fournisseur:
ProSci Inc.
Description:
Hippocalcin-Like Protein 1 (HPCAL1) is a neuron-specific calcium-binding member of the recoverin family which found in the retina and brain. HPCAL1 contains four EF-hand domains and it is highly similar to human hippocalcin protein. HPCAL1 is involved in the calcium-dependent regulation of rhodopsin phosphorylation. In addition, it may be of relevance for neuronal signalling in the central nervous system.
UOM:
1 * 50 µG
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