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Protéines et Peptides
Numéro de catalogue:
(PRSI92-506)
Fournisseur:
ProSci Inc.
Description:
Human protein N-terminal glutamine amidohydrolase (WDYHV1) is an enzyme that in humans is encoded by the WDYHV1 gene, belongs to the NTAQ1 family.WDYHV1 mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, which is an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. However,it does not act on substrates with internal or C-terminal glutamine andnon-glutamine residues in any position. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-499)
Fournisseur:
ProSci Inc.
Description:
Granulocyte-macrophage colony-stimulating factor is an enzyme that in mouse is encoded by the Csf2 gene, belongs to the GM-CSF family.CSF2 is a Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7391P)
Fournisseur:
ProSci Inc.
Description:
19 amino acids near the carboxy terminus of human AKT1S1.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-135)
Fournisseur:
ProSci Inc.
Description:
Serpin B5 is a secretive protein that belongs to the Serpin (Serine Protease Inhibitor) family and Ov-serpin subfamily. Serpin B5 is expressed in the prostate, testis, intestine, tongue, lung, and thymus. Serpin B5 exhibits no serine protease inhibitory activity. Serpin B5 also functions as tumour suppressor an angiogenesis inhibitor. It has been shown that Serpin B5 blocks the growth, invasion, and metastatic properties of mammary tumours. Furthermore, high expression of Serpin B5 is linked to squamous cell carcinoma in non-small-cell lung cancer.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-129)
Fournisseur:
ProSci Inc.
Description:
BCL2/Adenovirus E1B 19 kDa Protein-Iinteracting Protein 3 (BNIP3) is a single-pass membrane protein. BNIP3 is a member of the NIP3 family. BNIP3 contains a single Bcl-2 homology 3 domain and interacts with the E1B 19 kDa protein. BNIP3 have been associated with pro-apoptotic function. BNIP3 is an apoptosis-inducing protein that can overcome BCL2 suppression. It plays a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. BNIP3 involved in mitochondrial quality control via its interaction with SPATA18/MIEAP, response to mitochondrial damage, participates to mitochondrial protein catabolic process.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-451)
Fournisseur:
ProSci Inc.
Description:
Human recombinant interleukin 29 (from HEK293 cells)
UOM:
1 * 20 µG
Numéro de catalogue:
(PRSI91-340)
Fournisseur:
ProSci Inc.
Description:
Leukocyte-Associated Immunoglobulin-Like Receptor 2 (LAIR2) is a secreted, 131 amino acid protein that contains one Ig-like C2 type domain, making it a member of the Ig superfamily. When compared to LAIR-1, its transmembrane counterpart, it shares 83% amino acid identity across the signal sequence and extracellular domains; although one is secreted and one is membrane-bound, the two LAIR proteins are thought to have arisen from a common gene ancestor and appear to share similar adhesion profiles. This suggests that LAIR-2 may compete with LAIR-1 for ligand binding. A 114 amino acid alternate splice form of LAIR-2 is truncated at the C terminus, but retains the entire Ig domain. The expression profile of these splice forms, and the presence of orthologs in other species, have not been reported.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-553)
Fournisseur:
ProSci Inc.
Description:
OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40 L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controllling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7297P)
Fournisseur:
ProSci Inc.
Description:
16 amino acid peptide near the amino terminus of human SLC27A6.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7289P)
Fournisseur:
ProSci Inc.
Description:
15 amino acids near the carboxy terminus of human ERRF2.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI7309P)
Fournisseur:
ProSci Inc.
Description:
16 amino acids near the carboxy terminus of human KANK2.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-282)
Fournisseur:
ProSci Inc.
Description:
Activin proteins that belong to the transforming growth factor-beta (TGF- beta ) superfamily, exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding, type I and II receptors form a stable complex, resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity, and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB, also known as ActRIIB, is a type II receptor containing an extracellular domain (ECD), a transmembrane segment, and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A, activin B and inhibin A. Multiple ActRIIB isoforms can also be generated, which bind activin isoforms with different affinities.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-280)
Fournisseur:
ProSci Inc.
Description:
There exists two types of tryptophanyl tRNA synthetases, the cytoplasmic form called WARS, the mitochondrial form called WARS2. WARS catalyzes the aminoacylation of tRNA (trp) with tryptophan and is induced by interferon. WARS regulates ERK, Akt, eNOS activation pathway, which are related with angiogenesis, cytoskelatal reorganization and shear stess-reponsive gene expression.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6311P)
Fournisseur:
ProSci Inc.
Description:
NUMB peptide is used for blocking the activity of NUMB antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4797P)
Fournisseur:
ProSci Inc.
Description:
KINDLIN3 peptide is used for blocking the activity of ACVR1C antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI3489P)
Fournisseur:
ProSci Inc.
Description:
Raptor peptide is used for blocking the activity of the Raptor antibody.
UOM:
1 * 50 µG
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