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Protéines et Peptides
Numéro de catalogue:
(PRSI92-295)
Fournisseur:
ProSci Inc.
Description:
Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain, is expressed in neuroendocrine cells only. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. It implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. It seems to lack intrinsic enzyme activity, may play a role in the regulation of secretory granules via its interaction with SNTB2. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-348)
Fournisseur:
ProSci Inc.
Description:
Neuritin-like protein belongs to the neuritin family. Neuritin is a GPI-anchored protein that promotes neurite outgrowth and branching of neuritic processes in primary hippocampal and cortical cells. Neuritin expression also enhances the development of motor neuron axon arbors by promoting neuromuscular synaptogenesis and by stimulating the addition of new axon branches. Neuritin is induced by neuronal activity and by the neurotrophins, BDNF and NT3. NRN1L contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2209P)
Fournisseur:
ProSci Inc.
Description:
Bonzo peptide is used for blocking the activity of Bonzo antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2279P)
Fournisseur:
ProSci Inc.
Description:
F1A alpha peptide is used for blocking the activity of F1A alpha antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2273P)
Fournisseur:
ProSci Inc.
Description:
Toso peptide is used for blocking activity of Toso antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI2259P)
Fournisseur:
ProSci Inc.
Description:
Ski peptide is used for blocking activity of Ski antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI11-369)
Fournisseur:
ProSci Inc.
Description:
Human Recombinant Her2/ErbB2 Protein (from HEK293 cells)
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-293)
Fournisseur:
ProSci Inc.
Description:
Fatty acid-binding protein 5 (FABP5), is also known as Fatty acid-binding protein, epidermal (E-FABP), Psoriasis-associated fatty acid-binding protein homolog (PA-FABP). FABP5 / E-FABP belongs to the calycin superfamily and fatty-acid binding protein (FABP) family. FABP5 / E-FABP is highly expressed in psoriatic skin. FABP5 / E-FABP has high specificity for fatty acids and has highest affinity for C18 chain length. FABP5 may be involved in keratinocyte differentiation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI5187P)
Fournisseur:
ProSci Inc.
Description:
CLDN1 peptide is used for blocking the activity of CLDN1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5191P)
Fournisseur:
ProSci Inc.
Description:
OCLN peptide is used for blocking the activity of OCLN antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI90-438)
Fournisseur:
ProSci Inc.
Description:
CD276 (B7-H3) is a member of the B7/CD28 superfamily of costimulatory molecules serving as an accessory modulator of T cell response. B7 family molecules, which are expressed on antigen-presenting cells and display extracellular regions containing immunoglobulin (Ig) variable (V)- and constant (C)-like domains, are known to modulate T cell receptor (TCR)-mediated T cell activation by providing co-signals that are either stimulatory or inhibitory. B7-H3 provides a stimulatory signal to T cells. However, recent studies suggest a negative regulatory role for B7-H3 in T cell responses. B7-H3 inhibited T cell proliferation mediated by antibody to T cell receptor or allogeneic antigen-presenting cells. B7-H3 is a negative regulator that preferentially affects T(H)1 responses. B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. Recently, B7-H3 expression has also been found in a variety of different human cancers, including prostate cancer, clear cell renal cell carcinoma (ccRCC), non-small-cell lung cancer (NSCLC), pancreatic cancer, gastric cancer, ovarian cancer, colorectal cancer (CRC) and urothelial cell carcinoma. B7-H3 was expressed in some human cancers and correlated with poor outcome of cancer patients.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-446)
Fournisseur:
ProSci Inc.
Description:
CD278, also called inducible costimulator (ICOS) or CRP1 (CD28-related protein-1), is a member of the growing CD28 family of immune costimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS is expressed on most CD45RO+ cells. ICOS expression is upregulated within approximately 24-48 hours of activation on Th primed cells. B7-H2, a member of the B7 family of costimulatory ligands, has been identified as the ICOS ligand. The B7-H2/ICOS interaction appears to play roles in T cell dependent B cell activation and Th differentiation.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI90-447)
Fournisseur:
ProSci Inc.
Description:
Programmed Death-1 (PD-1, CD279) is a type I transmembrane protein belonging to the CD28/CTLA-4 family of immunoreceptors that mediate signals for regulating immune responses. Members of the CD28/CTLA-4 family have been shown to either promote T cell activation (CD28 and ICOS) or downregulate T cell activation (CTLA-4 and PD-1). CD279 is expressed on activated T-cells, B-cells, myeloid cells and on a subset of thymocytes. In vitro, ligation of CD279 inhibits TCR-mediated T-cell proliferation and production of IL-1, IL-4, IL-10 and IFN-gamma. In addition, CD279 ligation also inhibits BCR mediated signallling. CD279 deficient mice have a defect in peripheral tolerance and spontaneously develop autoimmune diseases.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3433P)
Fournisseur:
ProSci Inc.
Description:
West Nile virus peptide is used for blocking the activity of West Nile Virus Core Protein antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-169)
Fournisseur:
ProSci Inc.
Description:
CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-163)
Fournisseur:
ProSci Inc.
Description:
Human recombinant Cd3D (from HEK293 cells)
UOM:
1 * 1 EA
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