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Protéines et Peptides
Numéro de catalogue:
(PRSI96-679)
Fournisseur:
ProSci Inc.
Description:
erpin F1 (SERPINF1) is also known as Pigment epithelium-derived factor (PEDF), Cell proliferation-inducing gene 35 protein (PIG35). Serpin F1 belongs to the serpin family. Serpin F1 is expressed in quiescent cells. PEDF has a variety of functions including antiangiogenic, antitumorigenic, and neurotrophic properties. Endothelial cell migration is inhibited by SERPINF1/ PEDF. PEDF / SERPINF1 suppresses retinal neovascularization and endothelial cell proliferation. PEDF is also responsible for apoptosis of endothelial cells either through the p38 MAPK pathway or through the FAS/FASL pathway. PEDF also displays neurotrophic functions.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI96-670)
Fournisseur:
ProSci Inc.
Description:
S-100 protein beta chain (S100B),a member of the S-100 family, is also known as S-100 protein subunit beta and S100 calcium-binding protein B, which contains two EF-hand domains. S100B can weakly bind calcium but bind zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Also, S100B can bind to and initiate the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction,S100B may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Fuethermore,S100B could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. S100B may mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI5833P)
Fournisseur:
ProSci Inc.
Description:
TCTN1 peptide is used for blocking the activity of TCTN1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5837P)
Fournisseur:
ProSci Inc.
Description:
TCTN3 peptide is used for blocking the activity of TCTN3 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-246)
Fournisseur:
ProSci Inc.
Description:
Chloride Intracellular Channel Protein 2 (CLIC2) is a critical component of all living cells; it regulatescellular traffic of Chloride ion and it can be inserted into membranes anf form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions, channel activity depends on the pH. CLIC2 is involved in regulating membrane potential and organic solute transport. CLIC2 modulates the activity of RYR2 and inhibits Calcium influx. CLIC2 can be detected in the adult brain, liver, lung, heart, stomach, spleen and testis. It is expressed in fetal liver and adult skeletal muscle. CLIC2 is a potential candidate for one of many diseases linked to Xq28.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6395P)
Fournisseur:
ProSci Inc.
Description:
AP3B2 peptide is used for blocking the activity of AP3B2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-020)
Fournisseur:
ProSci Inc.
Description:
Epidermal growth factor (EGF) is a small mitogenic protein that is thought to be involved in mechanisms such as normal cell growth, oncogenesis, and wound healing. This protein shows both strong sequential and functional homology with human type-alpha transforming growth factor (hTGF alpha), which is a competitor for EGF receptor sites. EGF is a small 53 amino acid residue long protein that contains three disulfide bridges
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI91-576)
Fournisseur:
ProSci Inc.
Description:
Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitates an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-024)
Fournisseur:
ProSci Inc.
Description:
Testin belongs to the prickle/espinas/testin family. Testin contains three LIM zinc-binding domains and one PET domain, TES as a scaffold protein that may have a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. In addition, TES can also as a tumor suppressor, inhibits tumor cell growth, regulate the cell proliferation.TES interacts with many cytoskeletal proteins, such as Zyxin, Mena, Actin, Talin and VASP. The ability of TES to associate with alpha-actin, Zyxin and paxillin is dependent on the conformational state of the molecule.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6891P)
Fournisseur:
ProSci Inc.
Description:
LEMD2 peptide is used for blocking the activity of LEMD2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6397P)
Fournisseur:
ProSci Inc.
Description:
TMEM88 peptide is used for blocking the activity of TMEM88 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-275)
Fournisseur:
ProSci Inc.
Description:
Transcriptional repressor protein YY1（YY1）contains 4 C2H2-type zinc fingers and belongs to the YY transcription factor family. Multifunctional transcription factor exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. The effect on transcription regulation of the protein is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI5465P)
Fournisseur:
ProSci Inc.
Description:
OCIAD2 peptide is used for blocking the activity of OCIAD2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-242)
Fournisseur:
ProSci Inc.
Description:
Delta-like protein 4 (DLL4) is also known as Drosophila Delta homolog 4 (Delta4). DLL4 contains one DSL domain and eight EGF-like domains. DLL4 is expressed in vascular endothelium. DLL4 involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. DLL4 plays a role in the Notch signaling pathway. DLL4 activates Notch-1 and Notch-4.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI6229P)
Fournisseur:
ProSci Inc.
Description:
TM4SF1 peptide is used for blocking the activity of TM4SF1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6227P)
Fournisseur:
ProSci Inc.
Description:
TMEM192 peptide is used for blocking the activity of TMEM192 antibody.
UOM:
1 * 50 µG
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