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Protéines et Peptides
Numéro de catalogue:
(PRSI96-125)
Fournisseur:
ProSci Inc.
Description:
CD146, also known as the melanoma cell adhesion molecule (MCAM) or cell surface glycoprotein MUC18, is a 113kDa cell adhesion molecule currently used as a marker for endothelial cell lineage. As a member of the Immunoglobulin superfamily, It is expressed on chicken embryonic spleen and thymus, activated human T cells, endothelial progenitors such as angioblasts and mesenchymal stem cells, and strongly expressed on blood vessel endothelium and smooth muscle.
CD146 has been demonstrated to appear on a small subset of T and B lymphocytes in the peripheral blood of healthy individuals. The CD146+ T cells display an immunophenotype consistent with effector memory cells and have a distinct gene profile from the CD146- T cells. As a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions and a surface receptor,CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis or immune recognition.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI3013P)
Fournisseur:
ProSci Inc.
Description:
CARD10 peptide is used for blocking the activity of CARD10 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4865P)
Fournisseur:
ProSci Inc.
Description:
Aipl1 peptide is used for blocking the activity of Aipl1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI4053P)
Fournisseur:
ProSci Inc.
Description:
VISA peptide is used for blocking the activity of VISA antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-027)
Fournisseur:
ProSci Inc.
Description:
Angiopoietin-like protein 3 (ANGPTL3) is also known as Angiopoietin-related protein 3, Angiopoietin-5 (ANGPT5 / ANG-5), is a member of the angiopoietin-like family of secreted factors. ANGPTL3 / ANGPT5 is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), and increases plasma triglyceride and HDL cholesterol in rodents. ANGPTL3 inhibit endothelial lipase to catalyze HDL-phospholipid and increase HDL-PL levels. Circulating PL-riched HDL particles have high cholesterol efflux abilities.
UOM:
1 * 1 EA
Numéro de catalogue:
(PRSI92-497)
Fournisseur:
ProSci Inc.
Description:
Programmed cell death 1 ligand 2 (PD-L2), also known as butyrophilin B7-DC or PDCD1 ligand 2, belongs to the member of B7 family which can regulate the activation and tolerance of T cells. PD-L2 is one ligand for Programmed cell death 1(PD-1), and the other is PD-L1. These two ligands shares 34% aa sequence identity. Mouse PD-L2 gene encodes a 273 amino acids (aa) protein with a putative 19 aa signal peptide, a 201 aa extracellular region , a 21 aa transmembrane domain and a 32 aa cytoplasmic region. The mouse PD-L2 gene is highly expressed in heart, placenta, pancreas, lung and liver while expressed weakly in spleen, lymph nodes and thymus. Besides, the expression of PD-L2 gene can be induced on dendritic cells grown from peripheral blood mononuclear cells under CSF2 and IL4/interleukin-4 treatment, and up-regulated by IFNG/IFN-gamma stimulation in monocytes. PD-L2 usually functions in a PDCD1-independent manner and is involved in regulating costimulatory signal which is essential for T-cell proliferation and IFNG production. Recent studies demonstrate that the expression of PD-L2 on the tumour cells promotes CD8 T cell–mediated rejection of tumour cells, at both the induction and effector phase of antitumour immunity. Moreover, PD-L2 binds to PD-1 cells and enhances T cell killing in a PD-1–independent mechanism.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-494)
Fournisseur:
ProSci Inc.
Description:
Vascular endothelial growth factor (VEGF/VEGF-A ) is originally known as vascular permeability factor (VPF). It belongs to the PDGF family with a cysteine-knot structure comprised of eight conserved cysteine residues, and reckoned as a potent mediator in the process of angiogenesis and vasculogenesis in either fetus or adult. VEGF is particularly expressed in supraoptic , paraventricular nuclei and the choroid plexus of the pituitary, and abundant in the corpus luteum of the ovary and in kidney glomeruli. The rat VEGF protein contains a putative 20 amino acids (aa) signal peptide, and alternative splicing of rat VEGF gene produces isoforms of 120, 144, 164 and 188 aa. Rat VEGF164 respectively displays 97% and 88% aa identity with that regions of mouse and human VEGF. VEGF can bind to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin, and play important roles in inducing endothelial cell proliferation, promoting cell migration, inhibiting apoptosis and inducing permeabilisation of blood vessels.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-495)
Fournisseur:
ProSci Inc.
Description:
Programmed Death-1 (PD-1), firstly cloned from mouse T cell hybridoma 2B4.11, is one member of CD28/CTLA-4 superfamily. PD-1 belongs to type I transmembrane protein and acts as an important immunosuppressive molecule. This family also include members of CD28, CTLA-4 and ICOS.The mouse Programmed Death-1 protein, encoded by PD-1 gene, comprises four parts including a putative 20 aa signal peptide, a 149 aa extracellular region, a 21 aa transmembrane domain and a 98 aa cytoplasmic region. The cytoplamsic tail of PD-1 contains two structural motifs, an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) formed by two tyrosine residues which make the difference in PD-1 signal mediating. Mouse PD-1 is expressed in thymus and shares about 69% aa sequence identity with human PD-1. Recently, programmed death-1 (PD-1) with its ligands, programmed death ligand B7H1 (PD-L1) and B7DC (PD-L2), was found to regulate T-cell activation and tolerance, upon ligand binding, inhibiting T-cell effector functions in an antigen-specific manner. PD-1 gene knocked out mice would induce some autoimmune diseases, which suggests that PD-1 acts as a co-inhibitory molecule actively participating in maintaining peripheral tolerance. Thus, PD-1 may be a useful target for the immunologic therapy of carcinoma,infection,autoimmune diseases as well as organ transplantation.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-504)
Fournisseur:
ProSci Inc.
Description:
Human Glutathione S-transferase P (GSTP1) is an enzyme that in humans is encoded by the GSTP1 gene, belongs to the GST superfamily. It contains 1 GST C-terminal domain, 1 GST N-terminal domain, conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Besides, it regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-201)
Fournisseur:
ProSci Inc.
Description:
Fibroblast growth factor 19 (FGF19) is a secreted protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity. FGFRs can be important for regulation of glucose and lipid homeostasis. FGF19 has important roles as a hormone produced in the ileum in response to bile acid absorption. It has been shown to cause resistance to diet-induced obesity and insulin desensitisation and to improve insulin, glucose, and lipid profiles in diabetic rodents. FGF19 can be considered as a regulator of energy expenditure.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-199)
Fournisseur:
ProSci Inc.
Description:
UPRT is a cytoplasmic enzyme which belongs to the UPRTase family. UPRT is highly expressed in leukocytes, liver, spleen and thymus, with lower expression in brain, lung and skeletal muscle. UPRTcatalyses the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. UPRT is a potential target for rational design of drugs to treat parasitic infections and cancer
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-577)
Fournisseur:
ProSci Inc.
Description:
At least 23 different variants of Interferon- alpha are known. The individual proteins have molecular masses between 19-26 kD and consist of proteins with lengths of 156-166 and 172 amino acids. All IFN- alpha subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino-terminal ends are variable. Many IFN- alpha subtypes differ in their sequences at only one or two positions. Naturally occurring variants also include proteins truncated by 10 amino acids at the carboxyl-terminal end.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI92-579)
Fournisseur:
ProSci Inc.
Description:
Syntaxin 7 (STX7) is a member of a family of membrane-trafficking proteins named as soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs), and mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes. Syntaxin-7 has been shown to be present in both late endosomes and lysosomes, and to be required for both homotypic late endosome fusion and heterotypic fusion with lysosomes. STX7 has been shown to interact with STX8, VPS18, Vesicle-associated membrane protein 8 and VPS11.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6633P)
Fournisseur:
ProSci Inc.
Description:
EPAC2 peptide is used for blocking the activity of EPAC2 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI6631P)
Fournisseur:
ProSci Inc.
Description:
EPAC1 peptide is used for blocking the activity of EPAC1 antibody.
UOM:
1 * 50 µG
Numéro de catalogue:
(PRSI96-263)
Fournisseur:
ProSci Inc.
Description:
The epidermal growth factor receptor (EGFR; ErbB-1; HER1) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). Mutations affecting EGFR expression or activity could result in cancer.
UOM:
1 * 50 µG
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