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Eiwitten en peptiden
Itemnummer:
(PRSI4639P)
Leverancier:
ProSci Inc.
Omschrijving:
Wnt10a peptide is used for blocking the activity of Wnt10a antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-496)
Leverancier:
ProSci Inc.
Omschrijving:
Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.
UOM:
1 * 1 EA
Itemnummer:
(PRSI96-585)
Leverancier:
ProSci Inc.
Omschrijving:
Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene.This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
UOM:
1 * 50 µG
Itemnummer:
(PRSI96-595)
Leverancier:
ProSci Inc.
Omschrijving:
Programmed cell death protein 1 (PD-1) is also known as CD279 and PDCD1, is a type I membrane protein and is a member of the extended CD28/CTLA-4 family of T cell regulators. PDCD1 is expressed on the surface of activated T cells, B cells, macrophages, myeloid cells and a subset of thymocytes. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 is expressed on almost all murine tumor cell lines, including PA1 myeloma, P815 mastocytoma, and B16 melanoma upon treatment with IFN-γ. PD-L2 expression is more restricted and is expressed mainly by DCs and a few tumor lines. PD1 inhibits the T-cell proliferation and production of related cytokines including IL-1, IL-4, IL-10 and IFN-γ by suppressing the activation and transduction of PI3K/AKT pathway. In addition, coligation of PD1 inhibits BCR-mediating signal by dephosphorylating key signal transducer. In vitro, treatment of anti-CD3 stimulated T cells with PD-L1-Ig results in reduced T cell proliferation and IFN-γ secretion. Monoclonal antibodies targeting PD-1 that boost the immune system are being developed for the treatment of cancer.
UOM:
1 * 1 EA
Itemnummer:
(PRSI3681P)
Leverancier:
ProSci Inc.
Omschrijving:
ATF6 peptide is used for blocking the activity of ATF6 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3651P)
Leverancier:
ProSci Inc.
Omschrijving:
TLR6 peptide is used for blocking the activity of TLR6 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4967P)
Leverancier:
ProSci Inc.
Omschrijving:
EBI3 peptide is used for blocking the activity of EBI3 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4977P)
Leverancier:
ProSci Inc.
Omschrijving:
EBI3 peptide is used for blocking the activity of EBI3 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4973P)
Leverancier:
ProSci Inc.
Omschrijving:
Gle1 peptide is used for blocking the activity of Gle1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4959P)
Leverancier:
ProSci Inc.
Omschrijving:
TOM70 peptide is used for blocking the activity of TOM70 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4963P)
Leverancier:
ProSci Inc.
Omschrijving:
Gle1 peptide is used for blocking the activity of Gle1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSIXW-RP3143)
Leverancier:
ProSci Inc.
Omschrijving:
Methionine adenosyltransferase (EC 2.5.1.6) catalyzes the biosynthesis of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the major methyl donor for many of the transmethylation reactions in the body. The MAT2A promoter is highly GC rich, especially in the first 300 bp. The promoter contains several potential SP1-, v-myb-, and GATA-binding sites, as well as potential binding sites for C/EBP, HSF2, c-myb, and STATx. It can efficiently drive expression from a reporter gene in both Jurkat and 293 cells.
UOM:
1 * 1 EA
Itemnummer:
(PRSIXW-RP3253)
Leverancier:
ProSci Inc.
Omschrijving:
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein binds to fanconi anemia complementation group A protein, but its function is unknown. This gene results in two transcript variants encoding the same protein.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-400)
Leverancier:
ProSci Inc.
Omschrijving:
CD80 (B7-1) and CD86 (B7-2) together with their receptors CD28 and CTLA-4 constitute one of the dominant costimulatory pathways that regulate T cell and B cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. B7-1 is expressed on activated B cells, activated T cells and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be up-regulated through interferon-gamma. B7-1 and B7-2 are both members of the immunoglobulin superfamily. It has been observed that both human and mouse B7-1 and B7-2 can bind to either human or mouse CD28 and CTLA-4, suggesting that there are conserved amino acids which form the B7-1/B7-2/CD28/CTLA-4 critical binding sites.
UOM:
1 * 1 EA
Itemnummer:
(PRSI3639P)
Leverancier:
ProSci Inc.
Omschrijving:
TLR1 peptide is used for blocking the activity of TLR1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4741P)
Leverancier:
ProSci Inc.
Omschrijving:
ASAH1 peptide is used for blocking the activity of ASAH1 antibody.
UOM:
1 * 50 µG
Bel voor prijs
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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