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Eiwitten en peptiden
Itemnummer:
(PRSI92-452)
Leverancier:
ProSci Inc.
Omschrijving:
tumour necrosis factor receptor superfamily member 13B, also known as TNFRSF13B or more commonly as TACI (transmembrane activator and CAML interactor), is a transmembrane receptor protein found predominantly on the surface of B cells, which are an important part of the immune system.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-458)
Leverancier:
ProSci Inc.
Omschrijving:
Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene, belongs to the protease inhibitor I35 (TIMP) family. The protein complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-246)
Leverancier:
ProSci Inc.
Omschrijving:
Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-244)
Leverancier:
ProSci Inc.
Omschrijving:
UNC5B is a receptor for the netrin family of guidance molecules. It was identified as a mediator of the repulsive response in neurons and it is the only known netrin receptor with prominent endothelial expression. It has an important role in angiogenesis signalling.
UOM:
1 * 50 µG
Itemnummer:
(PRSI6693P)
Leverancier:
ProSci Inc.
Omschrijving:
FOXD4L1 peptide is used for blocking the activity of FOXD4L1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI96-397)
Leverancier:
ProSci Inc.
Omschrijving:
Sclerostin (SOST) is also known as Sclerosteosis, VBCH, is a secreted glycoprotein with a signal peptide for secretion and a C-terminal cysteine knot-like (CTCK) domain and belongs to the Cerberus/DAN family of bone morphogenetic protein (BMP) antagonists. Sclerostin is produced by the osteocyte and has anti-anabolic effects on bone formation. More recently Sclerostin has been identified as binding to LRP5/6 receptors and inhibiting the Wnt signalling pathway. Wnt pathway inhibition under these circumstances is antagonistic to bone formation (meaning Sclerostin antagonizes bone formation). It has been shown that SOST binds BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity. Sclerostin production by osteocytes is inhibited by parathyroid hormone, mechanical loading and cytokines including oncostatin M, cardiotrophin-1 and leukemia inhibitory factor. Sclerostin production is increased by calcitonin. Thus, osteoblast activity is self regulated by a negative feedback system. Mutations of Sclerostin is associated with the syndrome Sclerosteosis, and reduced sclerostin expression results in a milder form of the disorder called van Buchem disease.
UOM:
1 * 1 EA
Itemnummer:
(PRSI2319P)
Leverancier:
ProSci Inc.
Omschrijving:
ORAI1 peptide is used for blocking the activity of CIDE-B antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5067P)
Leverancier:
ProSci Inc.
Omschrijving:
LRFN2 peptide is used for blocking the activity of LRFN2 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5081P)
Leverancier:
ProSci Inc.
Omschrijving:
PCDH18 peptide is used for blocking the activity of PCDH12 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-409)
Leverancier:
ProSci Inc.
Omschrijving:
C-Type Lectin Domain Family 3 Member B (CLEC3B) is a serum and tissue protein and it contais a C-type lectin which binds to Ca++. CLEC3B is originally found in plasma, the concentrations approximately 10mg/l. It can bind to kringle 4 of plasminogen and enhance the activation of plaminogen to plasmin, catalyzed by tissue plasminogen activator in the presence of poly-D-lysine. In addition, CLEC3B may be involved in the packaging of molecules destined for exocytosis. Also, CLEC3B is best known as a prognostic marker in ovarian cancer.
UOM:
1 * 50 µG
Itemnummer:
(PRSI7349P)
Leverancier:
ProSci Inc.
Omschrijving:
17 amino acid peptide near the amino terminus of human DDX41.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-264)
Leverancier:
ProSci Inc.
Omschrijving:
Heat Shock Factor Protein 2 (HSF2) belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. HSF2 is widely expressed in many cells and tissues. HSF2 is located on Cytoplasmic during normal growth. But when it is activited, HSF2 moves to the nucleus.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-184)
Leverancier:
ProSci Inc.
Omschrijving:
Annexin A13 (ANXA13) belongs to the annexin family which plays a role in phospholipase inhibition, cytoskeletal interactions, intracellular signal transduction pathways and regulation of cellular growth. ANXA13 contains four annexin repeats and a pair of annexin repeats may form one binding site for calcium and phospholipid. ANXA13 is highly expressed in intestinal and kidney epithelial cells. The specific function of ANXA13 has not yet been determined; however it is associated with the plasma membrane of undifferentiated, proliferating crypt epithelial cells as well as differentiated villus enterocytes.
UOM:
1 * 50 µG
Itemnummer:
(PRSI96-594)
Leverancier:
ProSci Inc.
Omschrijving:
Programmed cell death 1 ligand 1 (PDL1) is also known as B7-H, B7H1, MGC142294, MGC142296, PD-L1, PDCD1L1 and PDCD1LG1,which is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses.PDL1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. This protein is broadly expressed in the majority of peripheral tissues as well as hematopoietic cells. Interaction between PDL1 and its receptors belonging to the CD28 family of molecules provide both stimulatory and inhibitory signals in regulating T cell activation and tolerance. PDL1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression.
UOM:
1 * 1 EA
Itemnummer:
(PRSI92-040)
Leverancier:
ProSci Inc.
Omschrijving:
Serine/Threonine-Protein Phosphatase PP1-Υ Catalytic Subunit (PPP1CC) is a member of the PPP phosphatase family. It is essential for cell division, participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. PPP1CC colocalizes with SPZ1 in the nucleus, with URI1 at mitochondrion, Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments. As a cofactor, PPP1CC binds one iron ion and one manganese ion per subunit.. In addition, PPP1CC may play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3653P)
Leverancier:
ProSci Inc.
Omschrijving:
TLR6 peptide is used for blocking the activity of TLR6 antibody.
UOM:
1 * 50 µG
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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