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Eiwitten en peptiden
Itemnummer:
(PRSI91-510)
Leverancier:
ProSci Inc.
Omschrijving:
B- and T-Lymphocyte Attenuator (BTLA) is a single-pass type I membrane protein containing 1 Ig-like V-type (immunoglobulin-like) domain. BTLA expression is induced during activation of T cells, and BTLA remains expressed on Th1 cells but not Th2 cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 and CTLA-4, BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors. BTLA is a lymphocyte inhibitory receptor that inhibits lymphocytes during immune response. BTLA also is a ligand for tumor necrosis factor (receptor) superfamily, member 14 (TNFRSF14), also known as herpes virus entry mediator (HVEM). BTLA-HVEM complexes negatively regulate T-cell immune responses.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-501)
Leverancier:
ProSci Inc.
Omschrijving:
Adiponectin is a secreted protein. It is synthesized exclusively by adipocytes and secreted into plasma. Adiponectin is an important adipokine that is involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Adiponectin Stimulates AMPK phosphorylation and activates in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Adiponectin also antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. It inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. Adiponectin may play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex: LMW, MMW or HMW.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-502)
Leverancier:
ProSci Inc.
Omschrijving:
Anterior Gradient Protein 2(AG-2) and Anterior Gradient Protein 3 (AG-3) are human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan (hAG-3 protein). AG-3 could serve as a prognostic marker for survival in patients with low grade and high grade serous ovarian carcinomas.
UOM:
1 * 50 µG
Itemnummer:
(PRSI92-516)
Leverancier:
ProSci Inc.
Omschrijving:
Apolipoprotein A1 (APOA1) is a secreted protein which belongs to the Apolipoprotein A1/A4/E family. APOA1 is the major protein component of high density lipoprotein (HDL) in plasma. APOA1 plays a critical role in various biological processes, such as Cholesterol metabolism, Lipid metabolism and transport, Steroid metabolism. APOA1 promotes cholesterol efflux from tissues to the liver and thus helps to clear cholesterol from arteries. Defects in this gene resulted in HDL deficiencies, including Tangier disease (TGD), systemic non-neuropathic amyloidosis, premature coronary artery disease, hepatosplenomegaly and progressive muscle wasting and weakness. In addition, ApoA-I is implicated in the anti-endotoxin function of HDL via interaction with lipopolysaccharide or endotoxin.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4461P)
Leverancier:
ProSci Inc.
Omschrijving:
Slitrk3 peptide is used for blocking the activity of Slitrk3 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4483P)
Leverancier:
ProSci Inc.
Omschrijving:
Slitrk4 peptide is used for blocking the activity of Slitrk4 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI4477P)
Leverancier:
ProSci Inc.
Omschrijving:
Slitrk5 peptide is used for blocking the activity of Slitrk5 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI3609P)
Leverancier:
ProSci Inc.
Omschrijving:
AES peptide is used for blocking the activity of AES antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5625P)
Leverancier:
ProSci Inc.
Omschrijving:
BCAS1 pepide is used for blocking the activity of BCAS1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5987P)
Leverancier:
ProSci Inc.
Omschrijving:
KPNA4 peptide is used for blocking the activity of KPNA4 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI90-141)
Leverancier:
ProSci Inc.
Omschrijving:
DNER is an activator of the Notch1 pathway. It mediates neuron-glia interaction during astrocytogenesis.
UOM:
1 * 1 EA
Itemnummer:
(PRSI90-124)
Leverancier:
ProSci Inc.
Omschrijving:
DLL1 (Delta-like protein; Delta1) is essential for postnatal arteriogenesis and contributes to tumour progression. DLL1 is involved in differentiation and self-renewal of adipocyte stem cells. Blocks the differentiation of progenitor cells into the B cell lineage while promoting the emergence of a population of cells with the characteristics of a T cell/NK-cell precursor.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-943)
Leverancier:
ProSci Inc.
Omschrijving:
Interleukin-18 is a secreted protein and it belongs to the IL-1 family. IL-18 is a proinflammatory cytokine and produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL-4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. After stimulation with IL-18, natural killer (NK) cells and certain T cells release another important cytokine called interferon- gamma (IFN- gamma ) or type II interferon that plays an important role in activating the macrophages or other cells.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-947)
Leverancier:
ProSci Inc.
Omschrijving:
Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and TRAF3, but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-200)
Leverancier:
ProSci Inc.
Omschrijving:
Eukaryotic Translation Initiation Factor 1B (EIF1B) is an element of a complex involved in recognition of the initiator codon during the scanning process. Translation is also initiated by the function of EIF1B in regulating the activity of ribosomal subunits 43S, 48S and 40S. EIF1B enables 43S ribosomal complexes to distinguish between cognate and near-cognate initiation codons, perceiving the nucleotide content of initiation codons.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-199)
Leverancier:
ProSci Inc.
Omschrijving:
Eukaryotic Translation Initiation Factor 1A, X-Chromosomal (EIF1AX) is an essential eukaryotic translation initiation factor that belongs to the eIF-1A family. EIF1AX is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA and has been shown to interact with IPO13. EIF1AX contains one S1-like domain and seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.
UOM:
1 * 50 µG
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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