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Eiwitten en peptiden
Itemnummer:
(J65878.MB)
Leverancier:
Thermo Scientific
Omschrijving:
A colorimetric substrate for caspase-3.
UOM:
1 * 25 mg
Itemnummer:
(PRSI91-310)
Leverancier:
ProSci Inc.
Omschrijving:
CST7 is a secreted protein and primarily expressed in peripheral blood cells and spleen.It is belongs to the cystatin family. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. This gene encodes a glycosylated cysteine protease inhibitor with a putative role in immune regulation through inhibition of a unique target in the hematopoietic system.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-342)
Leverancier:
ProSci Inc.
Omschrijving:
Legumain is a lysosomal cysteine protease which is a member of the peptidase C13 family. Though it is found in many tissues, it is highly expressed in the kidney, heart, and placenta. Legumain has a strict specificity for hydrolysis of asparaginyl bonds and can also cleave aspartyl bonds slowly, especially under acidic conditions. Over-expression Legumain in tumors is significant for invasion and metastasis. In addition, Legumain may be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system and negative regulation of neuron apoptosis.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-344)
Leverancier:
ProSci Inc.
Omschrijving:
Matrix Metalloproteinase-1 (MMP-1) is expressed by fibroblasts, keratinocytes, endothelial cells, monocytes and macrophages. MMP1 contains several distinct domains: a prodomain that is cleaved upon activation, a catalytic domain containing the zinc binding site, a short hinge region, and a carboxyl terminal (hemopexin like) domain. MMP-1 can degrade a broad range of substrates including types I, II, III, VII, VIII, and X collagens as well as casein, gelatin, alpha1 antitrypsin, myelin basic protein, L-Selectin, pro-TNF, IL1, IGFBP3, IGFBP5, pro-MMP2, and pro-MMP9. A significant role of MMP1 is the degradation of fibrillar collagens in extracellular matrix remodeling, characterized by the cleavage of the interstitial collagen triple helix into 3/4, 1/4 fragments. MMP1 may also be involved in enzyme cascades, cytokine regulation and cell surface molecule modulation.
UOM:
1 * 50 µG
Itemnummer:
(PRSI96-090)
Leverancier:
ProSci Inc.
Omschrijving:
Human recombinant SEMA4D (from HEK293 cells)
UOM:
1 * 1 EA
Itemnummer:
(PRSI92-431)
Leverancier:
ProSci Inc.
Omschrijving:
Interleukin-22 Receptor Subunit alpha-2 (IL22RA2) belongs to the type II cytokine receptor family. IL22RA2 is a secreted protein and contains three fibronectin type-III domains. IL22RA2 is widely expressed in many tissues. IL22RA2 functions as an IL22 antagonist and may be important in the regulation of inflammatory response. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
UOM:
1 * 50 µG
Itemnummer:
(PRSI5473P)
Leverancier:
ProSci Inc.
Omschrijving:
SRPX1 peptide is used for blocking the activity of SRPX1 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-104)
Leverancier:
ProSci Inc.
Omschrijving:
Stromal Cell-Derived Factor-1 (SDF-1) is a chemokine member of the intercrine family. SDF1 is expressed as five isoforms that differ only in the C terminal tail. SDF1 alpha and SDF1 beta are identical except for the four residues present in the C-terminus of SDF1 beta but absent from SDF1 alpha. SDF1 isoforms interact with CXCR4 and CXCR7 receptors on the cell surface, and can also bind syndecan4. SDF1 is known to influence lymphopoiesis, regulate patterning and cell number of neural progenitors, and promote angiogenesis. It also enhances the survival of myeloid progenitor cells.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-279)
Leverancier:
ProSci Inc.
Omschrijving:
Protein NDRG1 is a member of the N-Myc Downregulated Gene family, which is part of the alpha/ beta Hydrolase superfamily. Protein NDRG1 is a cytoplasmic protein that is involved in stress responses, hormone responses, cell growth and differentiation. Protein NDRG1 is necessary for p53-mediated caspase activation and apoptosis. Protein NDRG1 mutuations are reported to be the cause for hereditary motor and sensory neuropathy-Lom. Decreased NDRG1 expression in glioma is linked to tumor progression; overexpression of NDRG1 is connected to malignant status of esophageal cancer.
UOM:
1 * 50 µG
Itemnummer:
(PRSI96-686)
Leverancier:
ProSci Inc.
Omschrijving:
Semaphorin-4A (SEMA4A) is also known as Semaphorin-B (SEMAB), which belongs to the semaphorin family. SEMA4A contains one Ig-like C2-type (immunoglobulin-like) domain, one PSI domain and one sema domain. SEMA4A is cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. SEMA4A plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. SEMA4A also promotes phosphorylation of TIMD2 and inhibits angiogenesis. SEMA4A promotes axon growth cone collapse and inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
UOM:
1 * 1 EA
Itemnummer:
(PRSI96-627)
Leverancier:
ProSci Inc.
Omschrijving:
Polymeric immunoglobulin receptor (PIGR) is also known as Poly-Ig receptor, which can be cleaved into membrane secretory component (SC). PIGR is a type I transmembrane glycoprotein or a member of the immunoglobulin superfamily, and is synthesized by secretory epithelial cells and delivered to the basolateral plasma membrane where it can bind larger polymers of IgA (pIgA ) and pentameric IgM. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.
UOM:
1 * 1 EA
Itemnummer:
(PRSI3467P)
Leverancier:
ProSci Inc.
Omschrijving:
Caspase-7 peptide is used for blocking the activity of caspase-7 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI7021P)
Leverancier:
ProSci Inc.
Omschrijving:
PHLPP2 peptide is used for blocking the activity of PHLPP2 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI7003P)
Leverancier:
ProSci Inc.
Omschrijving:
SCUBE3 peptide is used for blocking the activity of SCUBE3 antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI7009P)
Leverancier:
ProSci Inc.
Omschrijving:
EED peptide is used for blocking the activity of EED antibody.
UOM:
1 * 50 µG
Itemnummer:
(PRSI91-946)
Leverancier:
ProSci Inc.
Omschrijving:
Tumor necrosis factor receptor superfamily member 12A(Tnfrsf12a) is a single-pass type I membrane protein and contains 1 TNFR-Cys repeat. It is weak inducer of apoptosis in some cell types.It promotes angiogenesis and it is the proliferation of endothelial cells. It may modulate cellular adhesion to matrix proteins.TNFR binds specifically to tumor necrosis factor (TNF) and blocks its interaction with cell surface TNF receptors. TNF is a naturally occurring cytokine that is involved in normal inflammatory and immune responses. It plays an important role in the inflammatory processes of rheumatoid arthritis (RA), polyarticular-course juvenile rheumatoid arthritis (JRA), and ankylosing spondylitis and the resulting joint pathology. In addition, TNF plays a role in the inflammatory process of plaque psoriasis. Elevated levels of TNF are found in involved tissues and fluids of patients with RA, psoriatic arthritis, ankylosing spondylitis (AS), and plaque psoriasis. Two distinct receptors for TNF (TNFRs), a 55 kilodalton protein (p55) and a 75 kilodalton protein (p75), exist naturally as monomeric molecules on cell surfaces and in soluble forms. Biological activity of TNF is dependent upon binding to either cell surface TNFR.
UOM:
1 * 50 µG
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 nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11.
De voorraad voor dit item is beperkt, maar kan beschikbaar zijn in een kortbijgelegen magazijn. Gelieve te controleren of u bent aangemeld op de site zodat de beschikbare voorraad weergegeven kan worden. Als het
nog steeds zichtbaar is en u hulp nodig heeft, gelieve VWR te contacteren via 016/38 50 11/
Dit product is gemarkeerd als beperkt en kan enkel gekocht worden door goedgekeurde verzendingsaccounts. Als u hulp nodig heeft gelieve dan het VWR-Regelgevend Departement te contacteren via regulatory_affairs@vwr.com.
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